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Evolution of structure and function of V-ATPases

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Abstract

Proton pumping ATPases/ATPsynthases are found in all groups of present-day organisms. The structure of V- and F-type ATPases/ATP synthases is very conserved throughout evolution. Sequence analysis shows that the V- and F-type ATPases evolved from the same enzyme already present in the last common ancestor of all known extant life forms. The catalytic and noncatalytic subunits found in the dissociable head groups of the V/F-type ATPases are paralogous subunits, i.e., these two types of subunits evolved from a common ancestral gene. The gene duplication giving rise to these two genes (i.e., encoding the catalytic and noncatalytic subunits) predates the time of the last common ancestor.

Mapping of gene duplication events that occurred in the evolution of the proteolipid, the noncatalytic and the catalytic subunits, onto the tree of life leads to a prediction for the likely subunit structure of the encoded ATPases. A correlation between structure and function of V/F-ATPases has been established for present-day organisms. Implications resulting from this correlation for the bioenergetics operative in proto-eukaryotes and in the last common ancestor are presented. The similarities of the V/F-ATPase subunits to an ATPase-like protein that was implicated to play a role in flagellar assembly are evaluated.

Different V-ATPase isoforms have been detected in some higher eukaryotes. These data are analyzed with respect to the possible function of the different isoforms (tissue specific, organelle specific) and with respect to the point in their evolution when these gene duplications giving rise to the isoforms had occurred, i.e., how far these isoforms are distributed.

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Author notes

  1. Paul Bernasconi

    Present address: Sandoz Crop Protection, 94304, Palo Alto, California

Authors and Affiliations

  1. Biology Department, University of California, 95064, Santa Cruz, California

    Henrik Kibak, Lincoln Taiz & Paul Bernasconi

  2. Department of Molecular and Cell Biology, University of Connecticut, 06269, Storrs, Connecticut

    Thomas Starke & Johann Peter Gogarten

Authors
  1. Henrik Kibak
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  2. Lincoln Taiz
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  3. Thomas Starke
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  4. Paul Bernasconi
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  5. Johann Peter Gogarten
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Kibak, H., Taiz, L., Starke, T. et al. Evolution of structure and function of V-ATPases. J Bioenerg Biomembr 24, 415–424 (1992). https://doi.org/10.1007/BF00762534

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