Abstract
Consider the plight of an extracellular enzyme, a permease, or an exported metabolite. Unprotected by the pH homeostatic mechanism of its maker, it must function or fail to do so in an environment ravaged by extremes of pH. An organism which can grow only over a narrow pH range need only export molecules able to function over a similarly narrow pH range. An organism which can grow over a wide pH range can greatly benefit from controlling syntheses of exported molecules so that they are synthesized only at appropriate ambient pH. No well-adapted organism would secrete an acid phosphatase into an alkaline environment.
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References
Arst HN Jr (1994) Regulation of gene expression by oxygen, phosphorus and pH. In: Martinelli SD, Kinghorn JR (eds) Aspergillus: 50 years on. Elsevier, Amsterdam, pp 369 - 380
Arst HN Jr, Bignell E, Tilburn J (1994) Two new genes involved in signalling ambient pH in Aspergillus nidulans. Mol Gen Genet 245: 787 - 790
Caddick MX, Arst HN Jr (1986) Structural genes for phosphatases in Aspergillus nidulans. Genet Res 47: 83 - 91
Caddick MX, Brownlee AG, Arst HN Jr (1986a) Phosphatase regulation in Aspergillus nidulans: responses to nutritional starvation. Genet Res 47: 93 - 102
Caddick MX, Brownlee AG, Arst HN Jr (1986b) Regulation of gene expression by pH of the growth medium in Aspergillus nidulans. Mol Gen Genet 203: 346 - 353
Churchill MEA, Travers AA (1991) Protein motifs that recognize structural features of DNA. Trends Biochem Sci 16: 92 - 97
Cohen BL (1980) Transport and utilisation of protein by fungi. In: Payne JW (ed) Microorganisms and nitrogen sources. Wiley, London, pp 411 - 430
Dijkema C, Rijeken RP, Kester HCM, Visser J (1986) 13CNMR studies on the influence of pH and nitrogen source on polyol pool formation in Aspergillus nidulans. FEMS Microbiol Lett 33: 125 - 131
Dorn G (1965) Genetic analysis of the phosphatases in Aspergillus nidulans. Genet Res 6: 13 - 26
Espeso EA, Tilburn J, Arst HN Jr, Penalva MA (1993) pH regulation is a major determinant in expression of a fungal penicillin biosynthetic gene. EMBO J 12: 3947 - 3956
Gander JE, Janovec S (1984) Regulation of metabolism in Penicillium charlesii by organic acids: role of L-tartaric acid. Curr Top Cell Reg 24: 99 - 109
Klevitt RE (1991) Recognition of DNA by Cys2,His2 zinc fingers. Science 253:1367 and 1393
Kobayashi H, Suzuki T, Kinoshita N, Unemoto T (1984) Amplification of the Streptococcus faecalis proton trans-locating ATPase by a decrease in cytoplasmic pH. J Bacterial 158: 1157 - 1160
Lacey J (1989) Pre-and post-harvest ecology of fungi causing spoilage of foods and other stored products. J Appl Bacterial Symp Suppl 67: 11S - 25S
Laub R, Schneider Y-J, Trouet A (1989) Antibiotic susceptibility of Salmonella spp. at different pH values. J Gen Microbial 135: 1407 - 1416
Lindberg RA, Rhodes WG, Eirich LD, Drucker H (1982) Extracellular acid proteases from Neurospora crassa. J Bacterial 150: 1103 - 1108
MacRae WD, Buxton FP, Sibley S, Garven S, Gwynne DI, Davies RW, Arst HN Jr (1988) A phosphate-repressible acid phosphatase gene from As-pergillus niger: its cloning, sequencing and transcriptional analysis. Gene 71: 339 - 348
Nahas E, Terenzi HF, Rossi A (1982) Effect of carbon source and pH on the production and secretion of acid phosphatase (EC 3.1.3.2) and alkaline phosphatase (EC 3.1.3.1) in Neurospora crassa. J Gen Microbial 128: 2017 - 2021
Orejas M, Espeso EA, Tilburn J, Sarkar S, Arst HN Jr, Penalva MA (1995) Activation of the Aspergillus PacC transcription factor in response to alkaline ambient pH requires proteolysis of the carboxy-terminal moiety. Genes Dev 9: 1622 - 1632
Rossi A, Arst HN Jr (1990) Mutants of Aspergillus nidulans able to grow at extremely acidic pH acidify the medium less than wild type when grown at more moderate pH. FEMS Microbial Lett 66: 51 - 53
Shah AJ, Tilburn J, Adlard MW, Arst HN Jr (1991) pH regulation of penicillin production in Aspergillus nidulans. FEMS Microbial Lett 77: 209 - 212
Suzuki M (1989) SPXX, a frequent sequence motif in gene regulatory proteins. J Mol Biol 207: 61 - 84
Suzuki M, Yagi N (1991) Structure of the SPXX motif. Proc R Soc Land B 246: 231 - 235
Tilburn J, Sarkar S, Widdick DA, Espeso EA, Orejas M, Mungroo J, Penalva MA, Arst HN Jr (1995) The Aspergillus PacC zinc finger transcription factor mediates regulation of both acid-and alkaline-expressed genes by ambient pH. EMBO J 14: 779 - 790
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© 1996 Springer-Verlag Berlin Heidelberg
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Arst, H.N. (1996). Regulation of Gene Expression by pH. In: Brambl, R., Marzluf, G.A. (eds) Biochemistry and Molecular Biology. The Mycota, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10367-8_10
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DOI: https://doi.org/10.1007/978-3-662-10367-8_10
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