Abstract
Multiple trauma patients and patients undergoing major surgical operations are predisposed to life-threatening sepsis by an apparently acquired immunological deficiency, which is accompanied by a high mortality rate (40 to 60%) [1]. Neutrophils represent the first line of defense against invading bacteria. However, impaired neutrophil function has been reported in severely injured patients [2] and in patients during early septic shock [3]. Surgery resulted in further depression of neutrophil function in patients with intra-peritoneal infections [4]. In these patients, relapses of infections were associated with a diminution of neutrophil function prior to any clinical evidence for infection [4]. Thus, patients at risk of sepsis or with sepsis might benefit from prophylactic augmentation and restoration of neutrophil function. Unfortunately, until recently, there has been no choice to counteract granulocyte dysfunctions which have been described in posttraumatic patients [2]. However, in mice, recombinant human granulocyte colony-stimulating factor (rhG-CSF) improved survival in a well-established sepsis model [5]. G-CSF is one of the important hemopoietic factors which plays a central role in precursor cell proliferation and differentiation into neutrophils [6]. In addition to the stimulation of proliferation and maturation, G-CSF enhances a variety of functions of neutrophils, including chemotaxis [7], superoxide generation [8], bactericidal function [9] and phagocytic activity [9]. Moreover, G-CSF may have beneficial effects on feedback regulation of cytokines [5, 10]. Thus, G-CSF might activate neutrophils on the one hand and provide an anti-inflammatory effect on the other.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Casey LC, Balk RA, Bone RC (1993) Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome. Ann Intern Med 119: 771–778
Lanser ME, Mao P, Brown G, Coleman B, Siegel JH (1985) Serum-mediated depression of neutrophil chemiluminescence following blunt trauma. Ann Surg 202: 111–118
Vespa siano MC, Lewandoski JR, Zimmerman JJ (1993) Longitudinal analysis of neutrophil superoxide anion generation in patients with septic shock. Crit Care Med 21: 666–672
Solomkin JS, Bauman MP, Nelson RD, Simmons RL (1981) Neutrophils dysfunction during the course of intra-abdominal infection. Ann Surg 194: 9–17
Gorgen I, Hartung T, Leist M, et al (1992) Granulocyte colony-stimulating factor treatment protects rodents against lipopolysaccharide-induced toxicity via suppression of systemic tumor necrosis factor-a. J Immunol 149: 919–924
Lieschke GJ, Burgess A W (1992) Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor. N Engl J Med 327: 28–35
Wang JM, Chen ZG, Colella S, et al (1988) Chemotactic activity of recombinant human granulocyte colony-stimulating factor. Blood 72: 1456–1460
Nathan CF (1989) Respiratory burst in adherent human neutrophils: Triggering by colony- stimulating factors CSF-GM and CSF-G. Blood 73: 301–306
Roilides E, Walsh TJ, Pizzo PA, Rubin M (1991) Granulocyte colony-stimulating factor enhances the phagocytic and bactericidal activity of normal and defective human neutrophils. J Infect Dis 163: 579–583
Kanazawa M, Ishizaka A, Hasegawa N, Suzuki Y, Yokohama T (1992) Granulocyte colony-stimulating factor does not enhance endotoxin-induced acute lung injury in guinea pigs. Am Rev Respir Dis 145: 1030–1035
Sprikkelman A, de Wolf JTHM, Vellenga E (1994) The application of hematopoietic growth factors in drug-induced agranulocytosis: A review of 70 cases. Leukemia 8: 2031–2036
Bone RC (1991) The pathogenesis of sepsis. Ann Intern Med 115: 457–469
Bone RC (1994) Gram-positive organisms and sepsis. Arch Intern Med 154: 26–34
Lynn WA, Golenbock DT (1992) Lipopolysaccharide antagonists. Immunol Today 13: 271–276
Keene AR, Cullen DJ (1983) Therapeutic intervention scoring system: Update 1983. Crit Care Med 11: 1–3
Bone RC (1992) American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20: 864–874
Weiss M, Gross-Weege W, Harms B, Schneider EM (1996) Filgrastim (rhG-CSF) related modulation of the inflammatory response in patients at risk of sepsis or with sepsis. Cytokine (in press)
Schmitz S, Franke H, Brusis J, Wichmann HE (1993) Quantification of the cell kinetic effects of G-CSF using a model of human granulopoiesis. Exp Hematol 21: 755–760
Lindemann A, Hermann F, Oster W, et al (1989) Hematologic effects of recombinant human granulocyte colony-stimulating factor in patients with malignancy. Blood 74: 2644–2651
Weiss M, Gross-Weege W, Schneider M, et al (1995) Enhancement of neutrophil function by in vivo fllgrastim treatment for prophylaxis of sepsis in surgical intensive care patients. J Crit Care 10: 21–26
Selig C, Nothdurft W (1995) Cytokines and progenitor cells of granulocytopoiesis in peripheral blood of patients with bacterial infections. Infect Immun 63: 104–109
Konig B, Konig W (1994) Effect of growth factors on Escherichia coli alpha-hemolysininduced mediator release from human inflammatory cells: Involvement of the signal transduction pathway. Infect Immun 62: 2085–2093
Weiss M, Gross-Weege W, Wernet P, Neidhardt H, Harms B, Schneider M (1994) Filgrastim (rhG-CSF) for prophylaxis and therapy of sepsis in surgical intensive care patients: Neutrophil function. Clinical Intensive Care (Suppl) 5: 96 (Abst)
Simms HH, D’Amico R (1994) Polymorphonuclear leukocyte dysregulation during the systemic inflammatory response syndrome. Blood 83: 1398–1407
Simms HH, D’Amico R (1994) Granulocyte colony-stimulating factor reverses septic shock-induced polymorphonuclear leukocyte dysfunction. Surgery 115: 85–93
Repp R, Valerius T, Sendler A, et al (1991) Neutrophils express the high affinity receptor for IgG (FcgRI, CD64) after in vivo application of recombinant human granulocyte colony-stimulating factor. Blood 78: 885–889
Kerst JM, de Haas M, van der Schoot E, et al (1993) Recombinant granulocyte colonystimulating factor administration to healthy volunteers: Induction of immunophenotypically and functionally altered neutrophils via an effect on myeloid progenitor cells. Blood 82: 3265–3272
Erbe DV, Collins JE, Shen L, Graziano RF, Fanger MW (1990) The effect of cytokines on the expression and function of Fc receptors for IgG on human myeloid cells. Mol Immuno127: 57–67
De Haas M, Kerst JM, Van der Schoot CE, et al (1994) Granulocyte colony-stimulating factor administration to healthy volunteers analysis of the immediate activating effects on circulating neutrophils. Blood 84: 3885–3894
Kuijpers TW, Tool ATJ, van der Schoot CE, et al (1991) Membrane surface antigen expression on neutrophils: A reappraisal of the use of surface markers for neutrophil activation. Blood 78: 1105–1111
Clancy RM, Leszczynska-Piziak J, Abramson SB (1992) Nitric oxide, an endothelial cell relaxation factor, inhibitis neutrophil superoxide anion production via a direct action on the NADPH oxidase. J Clin Invest 90: 1116–1121
Springer TA (1990) Adhesion receptors of the immune system. Nature 346: 425–434
Hogg N (1992) Roll, roll, roll your leucocyte gently down the vein. Immunol Today 13: 113–115
Strieter RM, Kunkel SL (1994) Acute lung injury: The role of cytokines in the elicitation of neutrophils. J Invest Med 42: 643–649
Rao KM, Currie MS, Cohen HJ, Peters WP (1994) Alterations in L-selectin expression and elastase activity in neutrophils from patients receiving granulocyte colony-stimulating factor alone or in conjunction with high-dose chemotherapy with autologous bone marrow transplantation. Lymphokine Cytokine Res 13: 383–390
Ohsaka A, Saionji K, Sato N, Mori T, Ishimoto K, Inamatsu T (1993) Granulocyte colony-stimulating factor downregulates the surface expression of the human leukocyte adhesion molecule-Ion human neutrophils in vitro and in vivo. Br J Haematol 84: 574–580
Tedder TF, Steeber DA, Pizcueta P (1995) L-selectin-deficient mice have impaired leukocyte recruitment into inflammatory sites. J Exp Med 181: 2259–2264
Cowley HC, Heney D, Gearing AJH, Hemingway I, Webster NR (1994) Increased circulating adhesion molecule concentrations in patients with the systemic inflammatory response syndrome: A prospective cohort study. Crit Care Med 22: 651–657
Sessler CN, Windsor AC, Schwartz M, et al (1995) Circulating ICAM-1 is increased in septic shock. Am J Respir Crit Care Med 151: 1420–1427
Xu BH, Gonzalo JA, Pierre YS, et al (1994) Leukocytosis and resistance to septic shock in intercellular adhesion molecule I-deficient mice. J Exp Med 180: 95–109
Aoki Y, Hiromatsu K, Kobayashi N, et al (1995) Protective effect of granulocyte colonystimulating factor against T-cell-mediated lethal shock triggered by superantigens. Blood 86: 1420–1427
Toumanen EI, Austrian R, Masure HR (1995) Pathogenesis of pneumococcal infection. N Engl J Med 11: 1280–1284
Kuhns DB, Alvord WG, Gallin JI (1995) Increased circulating cytokines, cytokine antagonists and E-selectin after intravenous administration of endotoxin in humans. J Infect Dis 171: 145–152
Hackett SP, Stevens DL (1992) Streptococcal toxic shock syndrome: Synthesis of tumor necrosis factor and interleukin-1 by monocytes stimulated with pyrogenic exotoxin A and streptolysin O. J Infect Dis 165: 879–885
Lorenz W, Reimund KP, Weitzel F, et al (1994) Granulocyte colony-stimulating factor prophylaxis before operation protects against lethal consequences of postoperative peritonitis. Surgery 116: 925–934
Eichacker PQ, Waisman Y, Natanson C, et al (1994) Cardiopulmonary effects of granulocyte colony-stimulating factor in a canine model of bacterial sepsis. J Appl Physiol 77: 2366–2373
Dinarello CA, Wolff SM (1993) The role of interleukin-1 in disease. N Engl J Med 328: 106–113
Hartung T, Docke WD, Gantner F, et al (1995) Effect of granulocyte colony-stimulating factor treatment on ex vivo blood cytokine response in human volunteers. Blood 85: 2482–2489
van Zee KJ, DeForge LE, Fischer E, et al (1991) IL-8 in septic shock, endotoxemia, and after IL-1 administration. J Immunol 146: 3478–3482
Kilgore KS, Shen JP, Miller BF, Ward PA, Warren JS (1995) Enhancement by the complement membrane attack complex of tumor necrosis factor-α induced endothelial cell expression of E-selectin and ICAM-1. J Immunol 155: 1434–1441
Denzlinger C, Holler E, Reisbach G, Hiller E, Wilmanns W (1994) Granulocyte colonystimulating factor inhibits the endogenous leukotriene production in tumour patients. Br J Haematol 86: 881–882
Emminger W, Emminger-Schmidmeier W, Peters C, et al (1990) Capillary leak syndrome during low dose granulocyte-macrophage colony-stimulating factor (rh GMCSF) treatment of a patient in a continuous febrile state. Blut 61: 219–221
Izumi T, Muroi K, Takatoku MA, Imagawa S, Hatake K, Miura Y (1994) Development of acute myeloblastic leukaemia in a case of aplastic anaemia treated with granulocyte colony-stimulating factor. Br J Haematol 87: 666–668
Kojima S, Inaba J, Kondo M, Kato K, Matsuyama T, Kodera Y (1995) Development of myelodysplasia with monosomy 7 in children with severe aplastic anemia after treatment with recombinant granulocyte colony-stimulating factor. Exp Hematol 230: 901–906
Schilero GJ, Oropello J, Benjamin E (1995) Impairment in gas exchange after granulocyte colony-stimulating factor (G-CSF) in a patient with the adult respiratory distress syndrome. Chest 107: 276–278
Demuynck H, Zachee P, Verhoef GEG, et al (1995) Risk of rhG-CSF treatment in druginduced agranulocytosis. Ann Hematol 70: 143–147
Heyll A, Aul C, Gogolin F, Thomas M, et al (1991) Granulocyte colony-stimulating factor (G-CSF) treatment in a neutropenic leukemia patient with diffuse interstitial pulmonary infiltrates. Ann Hematol 63: 328–332
Gillis S (1991) Cytokine receptors. Curr Opin Immunol 3: 315–319
Tweardy DJ, Burkhardt AL, Bolen J, Geahlen RL, Corey SJ (1993) G-CSF receptor signaling involves SRC-related and non-SRC-related tyrosine kinases with evidence of a threecomponent complex. In: Abraham NG, Shadduck RK, Levine AS, Takaku F (eds) Molecular Biology of Haematopoiesis. Vol 3. Intercept, Andover, pp 607–619
Tian SS, Lamb P, Seidel HM, Stein RB, Rosen J (1994) Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor. Blood 84: 1760–1764
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Weiss, M., Schneider, E.M., Radermacher, P. (1996). Low Dose G-CSF to Augment Host Defense and Counteract Progression of Sepsis. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine. Yearbook of Intensive Care and Emergency Medicine, vol 1996. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80053-5_14
Download citation
DOI: https://doi.org/10.1007/978-3-642-80053-5_14
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-60552-2
Online ISBN: 978-3-642-80053-5
eBook Packages: Springer Book Archive