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Risks of rhG-CSF treatment in drug-induced agranulocytosis

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Abstract

Nine patients with drug-induced agranulocytosis received recombinant human granulocyte colonystimulating factor (rhG-CSF) to accelerate myeloid recovery because of life-threatening infections related to neutropenia. All patients showed a quick recovery of their granulocyte counts. Side effects were substantial, however. Three patients, two with a severe infection and one with preexisting pulmonary infiltrates, developed worsening of their respiratory status during neutrophil recovery, resulting in clinical manifestations of the adult respiratory distress syndrome (ARDS). In view of these major complications, the exact place of hematopoietic growth factors in the treatment of drug-induced agranulocytosis remains to be determined.

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Authors and Affiliations

  1. Department of Hematology, University Hospital Gasthuisberg, Herestraat 49, B-3000, Leuven, Belgium

    H. Demuynck, P. Zachée, G. E. G. Verhoef & M. A. Boogaerts

  2. Intensive Care Unit, University Hospital Gasthuisberg, Leuven, Belgium

    M. Schetz, G. Van Den Berghe & P. Lauwers

Authors
  1. H. Demuynck
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  2. P. Zachée
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  3. G. E. G. Verhoef
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  4. M. Schetz
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  5. G. Van Den Berghe
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  6. P. Lauwers
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  7. M. A. Boogaerts
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Demuynck, H., Zachée, P., Verhoef, G.E.G. et al. Risks of rhG-CSF treatment in drug-induced agranulocytosis. Ann Hematol 70, 143–147 (1995). https://doi.org/10.1007/BF01682034

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  • DOI: https://doi.org/10.1007/BF01682034

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