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Selective Perfusion of Chemotherapeutic Agents

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Hepatocellular Carcinoma and Liver Metastases: Diagnosis and Treatment

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Abstract

As most chemotherapeutic drugs have a steep dose-response curve, the rationale for hepatic arterial infusion is to achieve a higher concentration of drugs in neoplastic lesions and to lower the systemic drug levels. Essays with labeled fluorodeoxyuridine (FUDR) show that drug concentration in neoplastic tissue after injection in the hepatic artery is nearly 15 times higher than after injection in the portal vein [1]. This study clearly demonstrates the advantage of administering regional chemotherapy through the hepatic artery, because tumorous areas in the liver obtain most of their blood supply from branches of the liver arteries whereas normal liver parenchyma is mainly supplied by the portal vein.

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  1. Cantonal Hospital, CH-1700, Fribourg, Switzerland

    Henri-Marcel Hoogewoud MD (Head of the Department of Radiology)

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© 1993 Springer-Verlag Berlin Heidelberg

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Hoogewoud, HM. (1993). Selective Perfusion of Chemotherapeutic Agents. In: Hepatocellular Carcinoma and Liver Metastases: Diagnosis and Treatment. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77981-7_8

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  • DOI: https://doi.org/10.1007/978-3-642-77981-7_8

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