Abstract
Topically, the tetrachlorodecaoxygen anion complex (TCDO) has a therapeutic effect in wound healing [2, 9] with an increase of pO2 in the capillary blood [3] and systematically in experimental infections [1], It constitutes a negatively charged complex of chlorine and oxygen (Cl4O10)n, MWn=1 = 301.8. Incubation with hemoproteins leads to complex degradation and the appearance of oxygen water in chloride [4], whereby toxic oxygen species are not formed [8]. Heme-ac-tivated TCDO was described to be bactericidal for a number of microbial species [6, 7], to enhance phagocytosis by resident peritoneal macrophages of mice [7], and to stimulate humoral and cellular immunity [1]. TCDO enhanced the phagocytosis-dependent chemiluminescence (CL) of polymorphonuclear cells (PMNs) only in whole blood in the presence of peroxidase but not using isolated cells [6].
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© 1989 Springer-Verlag Berlin Heidelberg
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Gillissen, G., Ostendorp, H. (1989). Influence of the Tetrachlorodecaoxygen Anion Complex on Phagocytosis of Peripheral Human Polymorphonuclear Cells in Chemiluminescence Assays. In: Gillissen, G., Opferkuch, W., Peters, G., Pulverer, G. (eds) The Influence of Antibiotics on the Host-Parasite Relationship III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73653-7_17
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DOI: https://doi.org/10.1007/978-3-642-73653-7_17
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