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Application of Celestine Blue B and Gallocyanine for Studying the Effect of Drugs on the Production of Reactive Oxygen and Halogen Species by Neutrophils

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Journal of Applied Spectroscopy Aims and scope

We investigated the effect of drugs (dapsone, paracetamol, and isoniazid) on the production of reactive oxygen and halogen species by neutrophils. The standard fluorescent method using scopoletin as well as recently developed fluorescent methods using oxazine dyes, celestine blue B, and gallocyanine were employed for this purpose. Celestine blue B reacts selectively with hypochlorous acid, while gallocyanine reacts mainly with the superoxide radical-anion, which reveals the regulatory effect of anti-inflammatory drugs on neutrophil NADPH-oxidase and myeloperoxidase responsible for the production of reactive oxygen and halogen species, respectively. These results indicate that gallocyanine and celestine blue B hold promise as chemosensors for studying the effect of drugs used in anti-inflammatory therapy for the neutrophil respiratory burst.

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Authors and Affiliations

  1. Belarusian State University, 220030, Minsk, Belarus

    V. E. Reut, D. V. Grigorieva & I. V. Gorudko

  2. Institute of Experimental Medicine, 917376, St. Petersburg, Russia

    A. V. Sokolov

  3. St. Petersburg State University, 999034, St. Petersburg, Russia

    A. V. Sokolov

  4. Federal Research and Clinical Center of PhysicalChemical Medicine of the Federal Medical Biological Agency, 199435, Moscow, Russia

    A. V. Sokolov & O. M. Panasenko

  5. Pirogov Russian National Research Medical University, 117997, Moscow, Russia

    O. M. Panasenko

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  1. V. E. Reut
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  2. D. V. Grigorieva
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  3. I. V. Gorudko
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  4. A. V. Sokolov
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Correspondence to V. E. Reut.

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Translated from Zhurnal Spektroskopii, Vol. 89, No. 4, pp. 637–645, July–August, 2020.

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Reut, V.E., Grigorieva, D.V., Gorudko, I.V. et al. Application of Celestine Blue B and Gallocyanine for Studying the Effect of Drugs on the Production of Reactive Oxygen and Halogen Species by Neutrophils. J Appl Spectrosc 87, 693–700 (2020). https://doi.org/10.1007/s10812-020-01056-5

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  • DOI: https://doi.org/10.1007/s10812-020-01056-5

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