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Cellular Immune Responses and Their Genetic Aspects in Drosophila

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Immunity in Invertebrates

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

Abstract

Despite the absence of immunoglobulin-like recognition molecules, the immune reactive blood cells (hemocytes) of invertebrates are capable of responding with a high degree of specificity against a diversity of nonself components. Foreign objects too large to be phagocytosed are sequestered by numerous blood cells that adhere to one another and to the foreign surface to form compact, multilayered cellular capsules that become melanized. Unfortunately, little is presently understood of the mechanism of nonself recognition in invertebrates. In some species, hemagglutinating sugar-specific binding proteins (lectins), which have been shown to be synthesized by and localized in the plasma membranes of various types of invertebrate blood cells, may severe are- cognitive role as antibody-like molecules or opsonins [53,54]. Other substances that appear to be likely candidates for recognition molecules in invertebrates are components of the phenoloxidase system which function in melanization reactions that are generally manifested in the immune response of these animals [38,52].

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References

  1. Ashida M, Dohke K (1980) Activation of prophenoloxidase by the activating enzyme of the silkworm, Bombyx mori. Insect Biochem 10: 37

    Google Scholar 

  2. Brehelin M (1982) Comparative study of structure and function of blood cells from two Drosophila species. Cell Tissue Res 221: 607–615

    Article  PubMed  CAS  Google Scholar 

  3. Carton Y, Kitano H (1979) Changes in the hemocyte population of Drosophila larvae after single and multiple parasitization by Cothonaspis ( Parasitic Cynipidae ). JInvertebr Pathol 34: 88–89

    Google Scholar 

  4. Carton Y, Bouletreau M, VanLenteren JC, Van Alphen JCM (1985) The Drosophila parasitic wasps. In: Ashburner M, Carson HL, Thompson JN (eds) The genetics and biology of Drosophila, vol 3. Academic Press, New York (in press)

    Google Scholar 

  5. Carton Y, Bouletreau M (1985) Encapsulation ability of Drosophila melanogaster: a genetic analysis. Dev Comp Immunol 9 (in press)

    Google Scholar 

  6. Gateff E, Shrestha R, Akai H (1984) Comparative ultrastructure of wild-type and tumorous cells of Drosophila. In: King RC, Akai H (eds) Insect ultrastructure, vol 2. Plenum, New York pp 559–579

    Chapter  Google Scholar 

  7. Götz P, Vey A (1974) Humoral encapsulation in Diptera (Insecta): defense reactions of Chironomus larvae against fungi. Parasitology 68: 193–205

    PubMed  Google Scholar 

  8. Hadorn E, Walker I (1960) Drosophila und Pseudeucoila I. Selektionsversuche zur Steigerung der Abwehrreaktion des Wirtes gegen den Parasiten. Rev Suisse Zool 67: 216–225

    Google Scholar 

  9. Hanratty WP, Ryerse JS (1981) A genetic melanotic neoplasm of Drosophila melanogaster. Dev Biol 38: 238–249

    Article  Google Scholar 

  10. Livingstone MA, Tempel BL (1983) Genetic dissection of monoamine neurotransmitter synthesis in Drosophila. Nature 303: 67–70

    Article  PubMed  CAS  Google Scholar 

  11. Messner B (1972) Die Rolle des Tyrosinasesystems in der immunologischen Abwehrreaktion bei Wirbellosen I. Insekten Zool Jahrb Physiol 76: 368–374

    CAS  Google Scholar 

  12. Nappi AJ (1970) Defense reactions of Drosophila euronotus larvae against the hymenopterous parasite Pseudeucoily bochei. J Invertebr Pathol 16: 408–418

    Article  PubMed  CAS  Google Scholar 

  13. Nappi AJ (1973a) Hemocytic changes associated with the encapsulation and melanization of some insect parasites. Exp Parasitol 33: 287–302

    Article  Google Scholar 

  14. Nappi AJ (1973b) The role of melanization in the immune reaction of larvae of Drosophila algonquin against Pseudeucoila bochei. Parasitology 66: 23–32

    Article  CAS  Google Scholar 

  15. Nappi A J (1974) Insect hemocytes and the problem of host recognition of foreignness. In: Cooper EL (ed) Contemporary topics in immunobiology, vol 4. Plenum, New York, pp 207–224

    Google Scholar 

  16. Nappi A J (1975 a) Cellular immune reactions of larvae of Drosophila algonquin against the parasite Pseudeucoila bochei. Parasitology 70: 189–194

    Google Scholar 

  17. Nappi AJ (1975b) Parasite encapsulation in insects. In: Maramorosch K, Shope R (eds) Invertebrate immunity. Mechanisms of invertebrate vector-parasite relations. Academic Press, New York, pp 293–326

    Google Scholar 

  18. Nappi AJ (1978) Immune reactions of invertebrates to foreign materials. In: Gershwin ME, Cooper EL (eds) Animal models of comparative and developmental aspects of immunity and disease. Pergamon, New York, pp 15–24

    Google Scholar 

  19. Nappi AJ (1981) Cellular immune response of Drosophila melanogaster against Asobara tabida. Parasitology 83: 319–324

    Google Scholar 

  20. Nappi AJ (1984) Hemocyte reactions and early pathological changes during melanotic tumor formation in Drosophila. J Invertebr Pathol 43: 395–406

    Article  Google Scholar 

  21. Nappi A J, Silvers M (1984) Cell surface changes during parasite encapsulation and tumorigenesis in Drosophila. Science 225: 1166–1168

    Article  PubMed  CAS  Google Scholar 

  22. Nappi AJ, Streams FA (1969) Hemocytic reactions of Drosophila melanogaster to the parasites Pseudeucoila mellipes and P. bochei. J Insect Physiol 15: 1551–1566

    Article  Google Scholar 

  23. Nappi AJ, Kmiecik J, Silvers M (1984) Cellular immune competence of a Drosophila mutant with neoplastic hematopoietic organs. J Invertebr Pathol 44: 220–227

    Article  Google Scholar 

  24. Poinar GO Jr, Leutenegger ■ (1971) Ultrastructural investigation of the melanization process in Culex pipiens ( Culicidae) in response to a nematode. J Ultrastruct Res 36: 149–158

    Google Scholar 

  25. Ratcliffe NA, Leonard C, Rowley AF (1984) Prophenoloxidase activation: nonself recognition and cell cooperation in insect immunity. Science 226: 557–559

    Article  PubMed  CAS  Google Scholar 

  26. Rizki TM (1957) Alterations in the haemocyte population of Drosophila melanogaster. J Morphol 100: 437–458

    Article  Google Scholar 

  27. Rizki TM (1962) Experimental analysis of hemocyte morphology in insects. Am Zool 2: 247–256

    Google Scholar 

  28. Rizki TM (1969) Hemocyte encapsulation of streptococci in Drosophila. J Invertebr Pathol 12: 339–343

    Article  Google Scholar 

  29. Rizki TM, Rizki RM (1959) Functional significance of the crystal cells in the larvae of Drosophila melanogaster. J Biophys Biochem Cytol 5: 235–240

    Article  PubMed  CAS  Google Scholar 

  30. Rizki TM, Rizki RM (1974a) Topology of the caudal fat body of the tumor mutant of Drosophila melanogaster. J Invertebr Pathol 24: 37–40

    Article  PubMed  CAS  Google Scholar 

  31. Rizki TM, Rizki RM (1974b) Basement membrane abnormalities in melanotic tumor formation of Drosophila. Experientia (Basel) 30: 543–546

    Article  CAS  Google Scholar 

  32. Rizki TM, Rizki RM (1978) The role of hemocytes in melanotic tumor formation. In: Bulla LA, Cheng TC (eds) Comparative pathobiologiy, vol 4. Plenum, New York, pp 85–96

    Google Scholar 

  33. Rizki TM, Rizki RM (1979) Cell interactions in the differentiation of a melanotic tumor in Drosophila. Differentiation 12: 167–178

    Article  PubMed  CAS  Google Scholar 

  34. Rizki TM, Rizki RM (1980) Hemocyte responses to implanted tissues in Drosophila melanogaster larvae. Wilhelm Roux’s Arch 189: 207 - 313

    Article  Google Scholar 

  35. Rizki TM, Rizki RM (1983) Blood cell surface changes in Drosophila mutants with melanotic tumors. Science 220: 73–75

    Article  PubMed  CAS  Google Scholar 

  36. Rizki TM, Rizki RM (1984a) Selective destruction of a host blood cell type by a parasitoid wasp. Proc Natl Acad Sci 81: 41

    Article  Google Scholar 

  37. Rizki TM, Rizki RM (1984b) The cellular defense system of Drosophila melanogaster. In: King RC, Akai H (eds) Insect ultrastructure, vol 2. Plenum, New York, pp 579–604

    Chapter  Google Scholar 

  38. Salt G (1970) The cellular defence reactions of insects. Cambridge University Press, London

    Book  Google Scholar 

  39. Schmidt SP, Essenberg RC, Sauer JR (1981) Evidence for a Dt dopamine receptor in the salivary glands of Amblyomma americanum ( L). J Cyclic Nucleotide Res 7: 375–384

    Google Scholar 

  40. Schmidt SP, Essenberg RC, Sauer JR (1982) A dopamine sensitive adenylate cyclase in the salivary glands of Amblyomma americanum ( L). Comp Biochem Physiol 72C: 9–14

    Google Scholar 

  41. Shrestha R, Gateff E (1982) Ultrastructure and cytochemistry of the cell types in the larval hematopoietic organs and hemolymph of Drosophila. Dev Growth Differ 24: 65–82

    Article  Google Scholar 

  42. Silvers M, Hanratty WP (1984) Alterations in the production of hemocytes due to a neoplastic mutation of Drosophila melanogaster. J Invertebr Pathol 44: 324–328

    Article  PubMed  CAS  Google Scholar 

  43. Smith VJ, Söderhäll K (1983) B-1,3 Glucan activation of crustacean hemocytes in vitro and in vivo. Biol Bull (Woods Hole) 164: 299–314

    Article  CAS  Google Scholar 

  44. Söderhäll K (1982) Prophenoloxidase activating system and melanization. A recognition mechanism of arthropods? A review. Dev Comp Immunol 6: 601–611

    PubMed  Google Scholar 

  45. Söderhäll K, Unestam T (1979) Activation of serum prophenoloxidase in arthropod immunity. The specificity of cell wall glucan activation and activation by purified fungal glycoproteins of crayfish phenoloxidase. Can J Microbiol 25: 406–414

    Google Scholar 

  46. Söderhäll K, Häll L, Unestam T, Nyhlen L (1979) Attachment of phenoloxidase to fungal cell walls in arthropod immunity. J Invertebr Pathol 34: 285–294

    Article  Google Scholar 

  47. Stark MB, Marshall AK (1931) The blood-forming organ of the larva of Drosophila melanogaster. Am Inst Homeopathy 23: 1204–1206

    Google Scholar 

  48. Taylor RL (1969) A suggested role for the polyphenol-phenoloxidase system in invertebrate immunity. J Invertebr Pathol 14: 427–428

    Article  PubMed  CAS  Google Scholar 

  49. Vandenberg RD, Mills RR (1974) Hormonal control of tanning by the American cockroach: cyclic AMP as a probable intermediate. J Insect Physiol 20: 623–627

    Article  Google Scholar 

  50. Vey A (1979) Effect of melanization inhibitors, anti-inflammatory drugs and irradiators on insect multicellular reactions. In: Weiser (ed) Progress in invertebrate pathology. Prague, pp 229–230

    Google Scholar 

  51. Walker I (1959) Die Abwehrreaktion des Wirten Drosophila melanogaster gegen die zoophage Cynipidae Pseudeucoila bochei Weld. Rev Suisse Zool 66: 569–632

    Google Scholar 

  52. Whitcomb RF, Shapiro M, Granados RR (1974) Insect defense mechanisms against microorganisms and parasitoids. In: Rockstein M (ed) The physiology of insects. Academic Press, New York, pp 447–536

    Google Scholar 

  53. Yeaton R (1981) Invertebrate lectins XI. Diversity of specificity, biological synthesis and function in recognition. Dev Comp Immunol 5: 535–545

    PubMed  CAS  Google Scholar 

  54. Yeaton R (1983) Wound responses in insects. Am Zool 23: 195–203

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Biology, Loyola University of Chicago, Chicago, Illinois, 60626, USA

    A. J. Nappi

  2. Laboratoire de Biologie et Génétique évolutives, CNRS, 91190, Gif-sur-Yvette, France

    Y. Carton

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  1. A. J. Nappi
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  2. Y. Carton
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Editor information

Editors and Affiliations

  1. Laboratoire de Pathologie Comparée, USTL, Place E. Bataillon, F-34060, Montpellier, France

    Michel Brehélin

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© 1986 Springer-Verlag Berlin Heidelberg

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Nappi, A.J., Carton, Y. (1986). Cellular Immune Responses and Their Genetic Aspects in Drosophila . In: Brehélin, M. (eds) Immunity in Invertebrates. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70768-1_13

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  • DOI: https://doi.org/10.1007/978-3-642-70768-1_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70770-4

  • Online ISBN: 978-3-642-70768-1

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