Abstract
Nicotinic acetylcholine receptors (AChRs) from electric organs and muscle of different species have been shown to be highly conserved proteins composed of four homologous subunits occurring in the stoichiometry α2βγδ and forming a pseudosymmetric pentameric complex (see Raftery et al. 1983). The availability of large quantities of AChR from Torpedo electric organ has greatly facilitated detailed studies of its structure and function. It has been demonstrated that the α2βγδ complex constitutes the complete physiological receptor for postsynaptic depolarization by ACh and contains both the binding sites for cholinergic ligands and the cation gating unit (Moore and Raftery 1980; Wu et al. 1981). Each subunit spans the postsynaptic membrane and each has been shown to be exposed to the lipid bilayer suggesting that all subunits may interact with the surrounding membrane in a related fashion (see Raftery et al. 1983).
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References
Conti-Tronconi BM, Raftery MA (1982) Annu Rev Biochem 51: 491
Conti-Tronconi BM, Dunn SMJ, Raftery MA (1982) Biochem Biophys Res Commun 107: 123
Dunn SMJ, Raftery MA (1982a) Proc Natl Acad Sci USA 79: 6757
Dunn SMJ, Raftery MA (1982b) Biochemistry 21: 6264
Dunn SMJ, Conti-Tronconi BM, Raftery MA (1983) Biochemistry 22: 2512
Moore HPH, Raftery MA (1980) Proc Natl Acad Sci USA 77: 4509
Noda M, Shimizu S, Tanabe T, Takai T, Kayano T, Ideda T, Takahashi H, Nakayama H, Kanaoka Y, Minammo N, Kangawa K, Matsuo H, Raftery MA, Hiorse T, Knayama S, Hayashida H, Miyata T, Numa S (1984) Nature 312: 121
Raftery MA, Dunn SMJ, Conti-Tronconi BM, Middlemas DS, Crawford RD (1983) Cold Spring 59
Harbor Symp Quant Biol 48:181 Wu WCS, Moore HPH, Raftery MA (1981) Proc Natl Acad Sci USA 78:775
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© 1986 Springer-Verlag Berlin Heidelberg
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Raftery, M.A., Conti-Tronconi, B.M., Dunn, S.M.J. (1986). Structure and Function of the Nicotinic Acetylcholine Receptor and of the Voltage-dependent Na+-Channel. In: Montalcini, R.L., Calissano, P., Kandel, E.R., Maggi, A. (eds) Molecular Aspects of Neurobiology. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70690-5_11
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DOI: https://doi.org/10.1007/978-3-642-70690-5_11
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