Abstract
Dilated cardiomyopathy (DCM) is a heterogeneous condition, and probably encompasses a number of different disease entities which manifest similarly in their later stages as heart failure, but which are aetiologically distinct. The recent recognition of familial disease with mendelian inheritance implies the significant role of single genes in disease pathology, and thus provides an avenue to identify the molecular abnormality. Such molecular differences may in the future allow genetic classification of these disorders.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Aslandis C (1992) Myotonic dystrophy. Nature 355: 548–551
Berko BAM, Swift M (1987) X-linked dilated cardiomyopathy. N Engl J Med 316: 1186–1191
Buxton J (1992) Detection of an unstable fragment of DNA specific to individuals with Myotonic dystrophy. Nature 355: (6360): 547–548
Codd MB, Sugrue DD, Gersh BJ, Melton LJ III (1989) Epidemiology of idiopathic dilated and hypertrophic cardiomyopathy: a population based study in Olmsted County, Minnesota, 1975–1984. Circulation 80: 564–572
Dec WG, Fuster V (1995) Idiopathic dilated cardiomyopathy. N Engl J Med 331: 1564–1575
Durand JB, Abchee AB, Roberts R (1995) Molecular and clinical aspects of inherited cardiomyopathies [Review]. Annals of Medicine 27(3): 311–317
Gillum RF (1986) Idiopathic cardiomyopathy in the United States 1970–1982. Am Heart J 111: 752–755
Goldblatt J (1987) Autosomal recessive inheritance of idiopathic dilated cardiomyopathy in a Madeira Portuguese Kindred. Clin Genet 31: 249–254
Graber HL, Unverferth DV, Baker PB, Ryan JM, Baba N, Wooley CF (1986) Evolution of a hereditary cardiac conduction and muscle disorder: a study involving a family with six generations affected. Circulation 74: 21–35
Harley G (1992) Myotonic dystrophy. Nature 355: 545–546
Kass S, MacRae C, Graber HL, Sparks EA, McNamara D, Boudoulas H, Basson CT, Baker P, Cody RJ, Fishman MC et al (1994) A gene defect that causes conduction system disease and dilated cardiomyopathy maps to chromosome 1p1-1q1. Nature Genet 7: 546–551
Keeling PJ, Gang Y, Smith G et al (1995) Familial dilated cardiomyopathy in the United Kingdom. Br Heart J 73: 417–721
Keeling PJ, McKenna WJ (1994) Clinical genetics of dilated cardiomyopathy. Herz 19: 91–96
Koike S, Kawa S, Yabu K, Endo R, Sasaki Y, Furta S, Ota M (1987) Familial dilated cardiomyopathy and human leucocyte antigen. A report of two family cases. J Heart Jpn 28: 941–945
Krajinovic M, Pinamonti B, Sinagra G, Vatta M, Severini GM, Milasin J, Falaschi A, Camerini F, Giacca M, Mestroni L, Group and the H. M. D. S. (1995) Linkage of familial dilated cardiomyopathy to chromosome 9 and the Heart Muscle Disease Study. Am J Hum Genet 57: 846–852
Mestroni L, Miani D, Di LA, Silvestri F, Bussani R, Filippi G, Camerini F (1990) Clinical and pathologic study of familial dilated cardiomyopathy. Am J Cardiol 65: 1449–1453
Michels VV, Moll PP, Miller FA et al (1992) The frequency of familial dilated cardiomyopathy in a series of patients with idiopathic dilated cardiomyopathy. N Engl J Med 326: 77–82
Muntoni F, Cau M, Ganau A et al (1993) Brief report: deletion of the dystrophin muscle-promoter region associated with X-linked dilated cardiomyopathy. N Engl J Med 329: 921–925
Muntoni F, Wilson L, Marrosu G, Marrosu MG, Cianchetti C, Mestroni L, Ganau A, Du-bowitz V, Sewry C (1995) A mutation in the dystrophin gene selectively affecting dystrophin expression in the heart J Clin Invest 96: 693–699
Olson TM, Keating MT (1996) Mapping a cardiomyopathy locus to chromosome 3p 22-p25. Journal of Clinical Investigation 97(2): 528–532
Torp A (1978) Incidence of congestive cardiomyopathy. Postgrad Med J 54: 435–439
Towbin JA, Hejtmancik JF, Brink P (1993) X-linked dilated cardiomyopathy. Molecular genetic evidence of linkage to the Duchenne muscular dystrophy (dystrophin) gene at the Xp21 locus. Circulation 87: 1854–1865
Yoshida K, Ikeda S, Nakamura A, Kagoshima M, Takeda S, Shoji S, Yanagisawa N (1993) Molecular analysis of the Duchenne muscular dystrophy gene in patients with Becker muscular dystrophy presenting with dilated cardiomyopathy. Muscle Nerve 16: 1161–1166
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Baig, M.K., Coonar, A.S., Goldman, J.H., McKenna, W.J. (1997). The Genetics of Dilated Cardiomyopathy. In: Schultheiss, HP., Schwimmbeck, P. (eds) The Role of Immune Mechanisms in Cardiovascular Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60463-8_26
Download citation
DOI: https://doi.org/10.1007/978-3-642-60463-8_26
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-61358-9
Online ISBN: 978-3-642-60463-8
eBook Packages: Springer Book Archive