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Prevention of Arterial Restenosis by Rapamycin and Mycophenolate Mofetil: A New Role for Novel Immunosuppressants in the Prevention of Post-Balloon Angioplasty Restenosis?

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The Role of Immune Mechanisms in Cardiovascular Disease

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Abstract

Angioplasty is a minimally invasive method for widening both stenotic coronary and peripheral atherosclerotic vessels. Restenosis is a late complication that affects almost 50% of vessels undergoing angioplasty within six months after the procedure (Nobuyoshi et al. 1988) and is characterized by vascular smooth muscle cell proliferation in the area of balloon catheter-induced injury. There has been a concerted effort to identify effective therapy for preventing or limiting this complication (Handley 1995), but despite a number of successful pharmacologic interventions in a variety of animal models of vascular injury, none of the agents (with perhaps the exception of angiopeptin (Eriksen et al. 1995)) has proven to be effective in clinical trials.

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Author information

Author notes

  1. X. Huang

    Present address: Fibrogen, Inc., 772 Lucerne Drive, Sunnyvale, CA, 94086, USA

  2. W. Cao

    Present address: D-233, Department of Nucleic Acid Systems, Division of Probe Identification, Chiron Corp., 4560 Horton Street, Emeryville, CA, 94608-2916, USA

Authors and Affiliations

  1. Laboratory for Transplantation Immunology, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, 94305-5247, USA

    R. V. Nair, C. R. Gregory, X. Huang, W. Cao & R. E. Morris

  2. Department of General Surgery, University of Arizona, College of Medicine, Tucson, AZ, 85724-5058, USA

    R. V. Nair

  3. Department of Surgery and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, 95616-8745, USA

    C. R. Gregory

Authors
  1. R. V. Nair
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  2. C. R. Gregory
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  3. X. Huang
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  4. W. Cao
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  5. R. E. Morris
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Editor information

Editors and Affiliations

  1. Abteilung für Kardiologie/Pulmologie, Universitätsklinikum Benjamin Franklin der Freien Universität Berlin, Hindenburgdamm 30, 12200, Berlin, Germany

    Heinz-Peter Schultheiss  & Peter Schwimmbeck  & 

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© 1997 Springer-Verlag Berlin Heidelberg

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Nair, R.V., Gregory, C.R., Huang, X., Cao, W., Morris, R.E. (1997). Prevention of Arterial Restenosis by Rapamycin and Mycophenolate Mofetil: A New Role for Novel Immunosuppressants in the Prevention of Post-Balloon Angioplasty Restenosis?. In: Schultheiss, HP., Schwimmbeck, P. (eds) The Role of Immune Mechanisms in Cardiovascular Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60463-8_24

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  • DOI: https://doi.org/10.1007/978-3-642-60463-8_24

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-61358-9

  • Online ISBN: 978-3-642-60463-8

  • eBook Packages: Springer Book Archive

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