Abstract
Polymorphonuclear leukocytes (PMNs) play a prominent role in the tissue injury associated with ischemia and reperfusion of a number of organs [4]. The adhesion of PMNs to the vascular endothelium is a critical step in PMN-mediated reperfusion injury [4, 5]. Furthermore, recent experimental evidence suggests that a number of adhesion molecules expressed on the surface of the PMNs and the endothelial cell (EC) regulate PMN-EC interactions [1, 17]. PMN-EC interactions occur in a highly orchestrated manner with the expression of distinct families of PMN and EC adhesion molecules at various times during the inflammatory response [17].
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© 1997 Springer-Verlag Berlin Heidelberg
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Lefer, D.J. (1997). Immunological Mechanisms in Myocardial Reperfusion Injury. In: Schultheiss, HP., Schwimmbeck, P. (eds) The Role of Immune Mechanisms in Cardiovascular Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60463-8_20
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DOI: https://doi.org/10.1007/978-3-642-60463-8_20
Publisher Name: Springer, Berlin, Heidelberg
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