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Cellular Immunity and Cardiac Remodeling After Myocardial Infarction: Role of Neutrophils, Monocytes, and Macrophages

  • Comorbidities of Heart Failure (CE Angermann, Section Editor)
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Abstract

Today, innate immunity is recognized as an important pathophysiologic factor and therapeutic target for cardiac remodeling after myocardial infarction (MI). The innate immune system exerts its function via soluble and cellular components. Recently, function and kinetics of immune cells after MI have been clarified using new innovative technology. Therefore, herein, we will discuss the function of neutrophils, monocytes, and macrophages in the pathophysiology of cardiac remodeling after MI in basic as well as clinical science.

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Hisahito Shinagawa declares that he has no conflict of interest. Stefan Frantz has received financial support through a grant from the Federal Ministry of Education and Research (BMBF).

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  1. Department of Cardiovascular Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan

    Hisahito Shinagawa

  2. Comprehensive Heart Failure Center, University of Würzburg, Würzburg, Germany

    Hisahito Shinagawa & Stefan Frantz

  3. Universitätsklinik und Poliklinik für Innere Medizin III, Universitätsklinikum Halle (Saale), Ernst-Grube-Straße 40, 06120, Halle (Saale), Germany

    Stefan Frantz

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  1. Hisahito Shinagawa
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This article is part of the Topical Collection on Comorbidities of Heart Failure

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Shinagawa, H., Frantz, S. Cellular Immunity and Cardiac Remodeling After Myocardial Infarction: Role of Neutrophils, Monocytes, and Macrophages. Curr Heart Fail Rep 12, 247–254 (2015). https://doi.org/10.1007/s11897-015-0255-7

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