Abstract
In situ hybridization in tissue sections has primarily been associated with RNA analysis in gene expression studies. More recently, in situ DNA hybridization in tissue sections has also gained increasing importance. The tissue context allows the correlation of specific genetic and morphological characteristics which is not possible by genetic analysis on a single cell level, e.g. in metaphase preparations or isolated interphase nuclei. Different cell types may be distinguished and malignant cells may be differentiated from non-malignant cells by genetic as well as morphological criteria.
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© 2002 Springer-Verlag Berlin Heidelberg
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Rieder, H., Sommerlad, C., Mehraein, Y., Giersberg, M., Marben, K., Rehder, H. (2002). Formalin-Fixed and Paraffin-Embedded Tissue Sections. In: Rautenstrauss, B.W., Liehr, T. (eds) FISH Technology. Springer Lab Manuals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56404-8_11
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DOI: https://doi.org/10.1007/978-3-642-56404-8_11
Publisher Name: Springer, Berlin, Heidelberg
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