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Lentiviral Vectors for Gene Therapy of HIV-Induced Disease

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Lentiviral Vectors

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 261))

Abstract

In recent years, enormous advances have been made in our understanding of HIV pathogenesis and in the development of effective therapeutic strategies to combat HIV infection. Combination antiretroviral drugs can effectively reduce HIV RNA in peripheral blood and lymphoid tissue to undetectable levels (COLLIER et al. 1996; CAVERT et al. 1997). The advent of highly active antiretroviral therapy (HAART) initially raised expectations for the possibility of complete eradication of the virus from infected individuals. However, cell-associated virus can act as a reservoir of HIV infection in quiescent cells and remain protected from the immune system and the effects of drugs (FINZI et al. 1997; LAFEUILLADE et al. 1998). This inability to eradicate the latent viral reservoir remains perhaps the most important limitation of drug therapy as a means to cure HIV infection. Other important limitations of antiretroviral drugs include the uniform eventual development of drug resistance, severe toxicity, and cumbersome schedules that hinder compliance.

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Authors and Affiliations

  1. Department of Medicine, Division of Hematology/Oncology, UCLA School of Medicine, Los Angeles, CA, 90095-1678, USA

    R. G. Amado

  2. Department of Microbiology and Immunology and Medicine, and UCLA AIDS Institute, UCLA School of Medicine, Los Angeles, CA, 90095-1678, USA

    I. S. Y. Chen

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  1. R. G. Amado
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  1. Department of Genetics and Microbiology, Faculty of Medicine, University of Geneva, CMU; 1 rue Michel-Servet, 1211, Geneva 4, Switzerland

    Didier Trono

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© 2002 Springer-Verlag Berlin Heidelberg

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Amado, R.G., Chen, I.S.Y. (2002). Lentiviral Vectors for Gene Therapy of HIV-Induced Disease. In: Trono, D. (eds) Lentiviral Vectors. Current Topics in Microbiology and Immunology, vol 261. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56114-6_12

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  • DOI: https://doi.org/10.1007/978-3-642-56114-6_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62667-8

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