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Fibroblast Growth Factors

  • Chapter
Peptide Growth Factors and Their Receptors I

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 95 / 1))

Abstract

Growth factors are multifunctional (Sporn and Roberts 1988) and the family of fibroblast growth factors (FGFs) is a case in point. Although FGF activities have been known to exist in tissue extracts for almost half a century (Trowell et al. 1939; Hoffman 1940), it has only been in the last 10 years that these activities have been characterized and the identity of many of the factors capable of stimulating fibroblast growth have been established. They include some of the interleukins (ILs), the tumor necrosis factors (TNFs), the platelet-derived growth factors (PDGFs), the transforming growth factors (TGFs), and the FGFs. The pleiotropic nature of each of these growth factors is highlighted by the fact that they share common activities on some cell types but have restricted activities on others. Thus, the capacity of crude or partially purified preparations of tissue and cell extracts (macrophages, as an example) to stimulate fibroblast proliferation is due to the presence of a combination of many distinct families of molecules. Hence the importance of obtaining structural data to distinguish molecules that share FGF activities.

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  1. A. Baird
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  2. P. Böhlen
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  1. Laboratory of Chemoprevention, National Cancer Institute, Bldg. 41, Room C-629, 20892, Bethesda, MD, USA

    Michael B. Sporn M. D.  & Anita B. Roberts Ph. D.  & 

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Baird, A., Böhlen, P. (1990). Fibroblast Growth Factors. In: Sporn, M.B., Roberts, A.B. (eds) Peptide Growth Factors and Their Receptors I. Handbook of Experimental Pharmacology, vol 95 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49295-2_7

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