Abstract
Platelet-derived growth factor (PDGF) is a ubiquitous mitogen that was originally discovered because it was the principal source of growth factor activity for mesenchymal cells in culture that was present in whole blood serum and missing in cell-free, plasma—derived serum (Kohler and Lipton 1974; Ross et al. 1974). The possibility that platelets might serve as a source for this growth factor activity had been postulated by Balk (1971). However, not until it was demonstrated that platelets could restore all of the growth factor activity missing from plasma did it become clear that these cells were the source of not only PDGF, but of other growth factors also present in whole blood serum. These include an epidermal growth factor-like molecule (Oka and Orth 1983), an angiogenic molecule (Miyazono et al. 1987), and transforming growth factor-β (TGF-β; Assoian et al. 1983; Childs et al. 1982), all of which appear to be sequestered within α-granules (White 1974; Witte et al. 1978; Kaplan et al. 1979 a, b; Gerrard et al. 1980).
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Raines, E.W., Bowen-Pope, D.F., Ross, R. (1990). Platelet-Derived Growth Factor. In: Sporn, M.B., Roberts, A.B. (eds) Peptide Growth Factors and Their Receptors I. Handbook of Experimental Pharmacology, vol 95 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49295-2_5
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