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Adrenergic Neurons in Mammals with Special Reference to Fluorescence Microscopical Studies

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Aspects of Neuroendocrinology

Abstract

Before the end of the 19th century it was proposed that two antagonistic systems, the sympathetic and the parasympathetic, were involved in mammalian autonomic nervous control (Gaskell, 1886). In the year of 1900 Langley (1900) was able to show that the autonomic nervous system was built up of 2 sets of neurons, one preganglionic and one postganglionic.

Some of the work described in this paper was supported by grants from the Swedish Medical Research Council (No: B69-14X-2207-03, B70-14X-2207-04), from Magnus Berg-wall’s Foundation, from Gustav and Majen Lindgren’s Foundation, and from Wilhelm and Martina Lundgren’s Foundation.

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References

  • Almgren, O.: Personal communication (1969).

    Google Scholar 

  • Amin, A. H., Crawford, T. B. B., Gaddum, J. H.: Distribution of substance P and 5-hydroxy-tryptamine in the central nervous system of dog. J. Physiol. (Lond.) 126, 596–618 (1954).

    CAS  Google Scholar 

  • Andén, N.-E., Carlsson, A., Häggendal, J.: Adrenergic mechanisms. Ann. Rev. Pharmacol. 9, 119–134 (1969).

    Article  PubMed  Google Scholar 

  • Andén, N.-E., Carlsson, A., Hillarp, N.-Å., Magnusson, T.: 5-Hydroxytryptamine release by nerve stimulation of the spinal cord. Life Sci. 3, 473–478 (1964).

    Article  PubMed  Google Scholar 

  • Andén, N.-E., Carlsson, A., Hillarp, N.-Å., Magnusson, T.: Noradrenaline release by nerve stimulation of the spinal cord. Life Sci. 4, 129–132 (1965).

    Article  PubMed  Google Scholar 

  • Andén, N.-E., Dahlström, A., Fuxe, K., Larsson, K.: Further evidence for the presence of nigro-noestriatal dopamine neurons in the rat. Amer. J. Anat. 116, 329–333 (1965).

    Article  PubMed  Google Scholar 

  • Andén, N.-E., Dahlström, A., Fuxe, K., Larsson, K., Olson, L., Ungerstedt, U.: Ascending monoamine neurons to the telencephalon and diencephalon. Acta physiol. scand. 67, 313–326 (1966).

    Article  Google Scholar 

  • Angelakos, E., Fuxe, K., Torchiana, M.: Chemical and histochemical evaluation of the distribution of catecholamines in the rabbit and guinea pig hearts. Acta physiol. scand. 59, 184–192 (1963).

    Article  PubMed  CAS  Google Scholar 

  • Angelakos, E., Glassman, T., Millard, P. M., King, M.: Regional distribution and subcellular localization of catecholamines in the frog heart. Comp. Biochem. Physiol. 15, 313–324 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Axelrod, J.: The formation, metabolism, uptake and release of noradrenaline and adrenaline. In: The clinical chemistry of monoamines (Varley-Gowenlock, ed.), p. 5–18. Amsterdam: Elsevier Publ. Co. 1963.

    Google Scholar 

  • Bacq, Z. M.: La pharmacologie du système nerveux autonome, et particulièrement du sympathique, d’après la théorie neurohumorale. Ann. Physiol. 10, 467–528 (1934).

    CAS  Google Scholar 

  • Banks, P., Helle, K.: The release of protein from the stimulated adrenal medulla. Biochem. J. 97, 40C (1965).

    PubMed  CAS  Google Scholar 

  • Banks, P., Helle, K. B., Mayor, D.: Evidence for the presence of a chromogranin-like protein in bovine splenic nerve granules. Molec. Pharmacol. 5, 210–212 (1969).

    CAS  Google Scholar 

  • Banks, P., Mangnall, D., Mayor, D.: The re-distribution of cytochrome oxidase, noradrenaline and adenosine triphosphate in adrenergic nerves constricted at two points. J. Physiol. (Lond.) 200, 745–762 (1969).

    CAS  Google Scholar 

  • Björling, M., Waldeck, B.: The disappearance of l-14C-nor-adrenaline formed from 14C-dopamine in vivo.Life Sci. 4, 2239–2242 (1965).

    Article  Google Scholar 

  • Blaschko, H.: The specific action of L-dopa decarboxylase. J. Physiol. (Lond.) 96, 50–51 P(1939).

    CAS  Google Scholar 

  • Blaschko, H., Comline, R. S., Schneider, F. H., Silver, M., Smith, A. D.: Secretion of a chromaffine granule protein, chromogranin, from adrenal gland after splanchnic stimulation. Nature (Lond.) 215, 58–59 (1967).

    Article  CAS  Google Scholar 

  • Boyle, F. C, Gillespie, J. S.: Relationship between the accumulation of noradrenaline and the development of fluorescence above a constriction in cat splenic nerves. J. Physiol. (Lond.) 195, 27–28 P (1968).

    Google Scholar 

  • Burnstock, G., Holman, M. E.: Spontaneous potentials at sympathetic nerve endings in smooth muscle. J. Physiol. (Lond.) 160, 446–480 (1962).

    CAS  Google Scholar 

  • Cannon, W. B., Rosenblueth, A.: Sympathin-E and sympathin-I. Amer. J. Physiol. 104, 557–574 (1933).

    CAS  Google Scholar 

  • Cannon, W. B., Uridil, J. E.: Studies on the conditions of activity in endocrine glands. VIII. Some effects on the denervated heart of stimulating the nerves of the liver. Amer. J. Physiol. 58, 353–354 (1921).

    CAS  Google Scholar 

  • Carlsson, A.: Drugs which block the storage of 5-hydroxytryptamine and related amines. In: Handbuch der experimentellen Pharmakologie (V. Ersparmer, ed.), p. 529–592. Berlin-Heidelberg-New York : Springer 1965.

    Google Scholar 

  • Carlsson, A. Hillarp, N.-Å., Waldeck, B.: Analysis of the Mg++-ATP dependent storage mechanism in the amine granules of the adrenal medulla. Acta physiol. scand. 59, Suppl. 215, 1–38 (1963).

    Google Scholar 

  • Carlsson, A., Lindqvist, M., Magnusson, T., Waldeck, B.: On the presence of 3-hydroxytryptamine in brain. Science 127, 471 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Corrodi, H., Jonsson, G.: The formaldehyde fluorescence method for the histochemical demonstration of biogenic amines. A review on the methodology. J. Histochem. Cytochem. 15, 65–78 (1967).

    Article  CAS  Google Scholar 

  • Dahlström, A.: Observations on the accumulation of noradrenaline in the proximal and distal parts of peripheral adrenergic nerves after compression. J. Anat. (Lond.) 99, 677–689 (1965).

    Google Scholar 

  • Dahlström, A.: The intraneuronal distribution of noradrenaline and the transport and life-span of amine storage granules in the sympathetic adrenergic neuron. M. D. Thesis, Stockholm (1966).

    Google Scholar 

  • Dahlström, A.: The effect of reserpine and tetrabenazine on the accumulation of noradrenaline in the rat sciatic nerve after ligation. Acta physiol. scand. 69, 167–179 (1967a).

    Article  PubMed  Google Scholar 

  • Dahlström, A.: The transport of noradrenaline between two simultaneously performed ligations of the sciatic nerves of rat and cat. Acta physiol. scand. 69, 158–166 (1967b).

    Article  PubMed  Google Scholar 

  • Dahlström, A.: Effect of colchicine on transport of amine storage granules in sympathetic nerves of rat. Europ. J. Pharmacol. 5, 111–113 (1968).

    Article  Google Scholar 

  • Dahlström, A.: The effects of drugs on axonal transport of amine storage granules. In: New Aspects of Storage and Release Mechanisms of Catecholamines. Bayer Symposium II. Berlin-Heidelberg-New York: Springer 1970 (in press).

    Google Scholar 

  • Dahlström, A.: Fuxe, K.: Evidence for the existence of monoamine containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons. Acta physiol. scand. 62, Suppl. 232, 1–55 (1964a).

    Google Scholar 

  • Dahlström, A.: Fuxe, K.: A method for the demonstration of adrenergic nerve fibres in peripheral nerves. Z. Zell-forsch. 62, 602–607 (1964b).

    Article  Google Scholar 

  • Dahlström, A.: Fuxe, K.: A method for the demonstration of monoamine containing nerve fibres in the central nervous system. Acta physiol. scand. 60, 293–294 (1964 c).

    Article  Google Scholar 

  • Dahlström, A.: Fuxe, K.: Evidence for the existence of monoamine containing neurons in the central nervous system. II. Experimentally induced changes in the intraneuronal amine levels of bulbospinal neuron systems. Acta physiol. scand. 64, Suppl. 247, 1–36 (1965).

    Google Scholar 

  • Dahlström, A.: Fuxe, K., Hillarp, N.-Å.: Site of action of reserpine. Acta pharmacol. (Kbh.) 22, 277–292 (1965).

    Article  Google Scholar 

  • Dahlström, A.: Fuxe, K., Kernell, D., Sedvall, G.: Reductions of the monoamine stores in the terminals of bulbospinal neurons following stimulation in the medulla oblongata. Life Sci. 4, 1207–1212 (1965).

    Article  PubMed  Google Scholar 

  • Dahlström, A., Fuxe, K., Mya-Tu, M., Zetterström, B. E. M.: Some observations on the adrenergic innervation of the dog’s heart. Amer. J. Physiol. 209, 689–692 (1965).

    PubMed  Google Scholar 

  • Dahlström, A., Häggendal, J.: Some quantitative studies on the noradrenaline content in the cell bodies and terminals of a sympathetic adrenergic neuron system. Acta physiol. scand. 67, 271–277 (1966a).

    Article  PubMed  Google Scholar 

  • Dahlström, A., Häggendal, J.: Studies on the transport and life-span of amine storage granules in a peripheral adrenergic neuron system. Acta physiol. scand. 67, 278–288 (1966b).

    Article  PubMed  Google Scholar 

  • Dahlström, A., Häggendal, J.: Studies on the transport and life-span of amine storage granules in the adrenergic neuron system of the rabbit sciatic nerve. Acta physiol. scand. 69, 153–157 (1967).

    Article  PubMed  Google Scholar 

  • Dahlström, A., Häggendal, J.: Recovery of noradrenaline in adrenergic axons of rat sciatic nerves after reserpine treatment. J. pharm, pharmacol. 21, 633–638 (1969).

    Article  Google Scholar 

  • Dahlström, A., Häggendal, J.: Axonal transport of amine storage granules in sympathetic adrenergic neurons. In: Biochemistry of Simple Neuronal Models (E. Costa and E. Giacobini, eds.). New York: Raven Press 1970a (in press).

    Google Scholar 

  • Dahlström, A., Häggendal, J.: A reevaluation of the life-span of amine storage granules with regard to their capacity to store endogenous noradrenaline in adrenergic nerve terminals of the rat. (In preparation) (1970).

    Google Scholar 

  • Dahlström, A., Häggendal, J., Hökfelt, T.: The noradrenaline content of the varicosities of sympathetic adrenergic nerve terminals in the rat. Acta physiol. scand. 67, 287–294 (1966).

    Google Scholar 

  • Dahlström, A., Hökfelt, T.: Unpublished observations.

    Google Scholar 

  • Dahlström, A., Jonason, J.: DOPA-decarboxylase activity in sciatic nerves of the rat after constriction. Europ. J. Pharmacol. 4, 377–383 (1968).

    Article  Google Scholar 

  • Dahlström, A., Jonason, J., Norberg, K.-A.: Monoamine oxidase activity in rat sciatic nerves after constriction. Europ. J. Pharmacol. 6, 248–254 (1969).

    Article  Google Scholar 

  • Dale, H. H., Feldberg, W.: The chemical transmission of secretory impulses to the sweat glands of the cat. J. Physiol. (Lond.) 82, 121–128 (1934).

    CAS  Google Scholar 

  • Davies, B. N., Horton, E. W., Withrington, P. G.: The occurrence of prostaglandin E2 in splenic venous blood of the dog following splenic nerve stimulation. J. Physiol. (Lond.) 188, 38P–39P (1967).

    CAS  Google Scholar 

  • Davison, P.: Neurotubules and neurofilaments : Possible implications in axoplasmic flow. In : Biochemistry of Simple Neuronal Models (E. Costa and E. Giocobini, eds.). New York: Raven Press 1970 (in press).

    Google Scholar 

  • Dixon, W. E., Hamill, P.: The mode of action of specific substances with special reference to secretin. J. Physiol. (Lond.) 38, 314–336 (1909).

    CAS  Google Scholar 

  • Edwards, D. C, Fenton, E. L., Kakari, S., Large, B. J., Papadaki, L., Zaimis, E.: Effects of nerve growth factor in new-born mice, rats and kittens. J. Physiol. (Lond.) 186, 10P–12P (1966).

    Google Scholar 

  • Ehinger, B.: Distribution of adrenergic nerves to orbital structures. Acta physiol. scand. 62, 291–292 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Elliot, T. R.: The action of adrenaline. J. Physiol. (Lond.) 32, 401–467 (1905).

    Google Scholar 

  • Ernyei, A., Young, M. R.: Pulsatile and myelinforming activities of Schwann cells in vitro.J. Physiol. (Lond.) 183, 469–480 (1966).

    CAS  Google Scholar 

  • Eränkö, O.: The practical histochemical demonstration of catecholamines by formaldehyde—induced fluorence. J. roy. micr. Soc. 87, 259–276 (1967).

    PubMed  Google Scholar 

  • Euler, U. S. von : A specific sympathomimetic ergone in adrenergic nerve fibres (sympathin) and its relations to adrenaline and noradrenaline. Acta physiol. scand. 12, 73–97 (1946).

    Article  Google Scholar 

  • Euler, U. S. von : Identification of the sympathomimetic ergone in adrenergic nerves of cattle (sympathin N) with laevonoradrenaline. Acta physiol. scand. 16, 63–74 (1948).

    Article  Google Scholar 

  • Euler, U. S. von, Hillarp, N.-Å.: Evidence for the presence of noradrenaline in submicroscopic structures of adrenergic axons. Nature (Lond.) 177, 44–45 (1956).

    Article  Google Scholar 

  • Falck, B., Häggendal, J., Owman, C.: The localization of adrenaline in adrenergic nerves in the frog. Quart. J. exp. Physiol. 48, 253–257 (1963).

    CAS  Google Scholar 

  • Falck, B., Owman, C.: A detailed methodological description of the fluorescence method for the cellular demonstration of biogenic monoamines. Acta Univ. Lund., sect. II, 7, 1–23 (1965).

    Google Scholar 

  • Fink, R. P., Heimer, L.: Two methods for selective silver impregnation of degenerating axons and their synaptic endings in the central nervous system. Brain Res. 4, 369–374 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Folkow, B., Häggendal, J.: Quantitative studies on the transmitter release at adrenergic nerve endings. Acta physiol. scand. 70, 453–454 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Folkow, B., Häggendal, J., Lisander, B.: Extent of release and elimination of noradrenaline at peripheral adrenergic nerve terminals. Acta physiol. scand., Suppl. 307, 1–38 (1967).

    CAS  Google Scholar 

  • Fuxe, K.: Evidence for the existence of monoamine containing neurons in the central nervous system. IV. The distribution of monoamine nerve terminals in the central nervous system. Acta physiol. scand. 64, Suppl. 247, 38–85 (1965).

    Google Scholar 

  • Fuxe, K., Gunne, L.-M.: Depletion of the amine stores in brain catecholamine terminals on amygdaloid stimulation. Acta physiol. scand. 62, 493–494 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Fuxe, K., Hökfelt, T., Nilsson, O.: A fluorescence and electronmicroscopic study on certain brain regions rich in monoamine terminals. Amer. J. Anat. 117, 33–46 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Fuxe, K., Sedvall, G.: The distribution of adrenergic nerve fibres to the blood vessels of skeletal muscle. Acta physiol. scand. 64, 75–86 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Gaskell, W. H.: On the structure, distribution and function of the nerves which innervate the visceral and vascular systems. J. Physiol. (Lond.) 7, 1–80 (1886).

    CAS  Google Scholar 

  • Geffen, L. B., Rush, R. A.: Transport of noradrenaline in sympathetic nerves and the effect of nerve impulses on its contribution to transmitter stores. J. Neurochem. 15, 925–930 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Gilmore, N., Vane, J. R., Wyllie, J. H.: Prostaglandins released by the spleen. Nature (Lond.) 218, 1135–1140 (1968).

    Article  CAS  Google Scholar 

  • Häggendal, J.: An improved method for the fluorimetric determination of small amounts of adrenaline and noraderenaline in plasma and tissue. Acta physiol. scand. 59, 242–254 (1963).

    Article  Google Scholar 

  • Häggendal, J.: On release of transmitter from adrenergic nerve terminals at nerve activity. Acta physiol. scand., Suppl. 330, 29 (1969).

    Google Scholar 

  • Häggendal, J.: A hypothetical feed-back mechanism regulating the noradrenaline release from adrenergic nerves at nerve activity. In : New Aspects of Storage and Release Mechanisms of Catecholamines. Bayer Symposium. II Berlin-Heidelberg-New York : Springer 1970 (in press).

    Google Scholar 

  • Häggendal, J.: Dahlström, A.: The transport and life-span of amine storage granules in bulbospinal noradrenaline neurons of the rat. J. Pharm. Pharmacol. 21, 55–57 (1969).

    Article  PubMed  Google Scholar 

  • Häggendal, J., Dahlström, A.: The recovery of noradrenaline in adrenergic nerve terminals of the rat after reserpine treatment. J. pharm, pharmacol. (in press) (1970a).

    Google Scholar 

  • Häggendal, J., Dahlström, A.: Uptake and retention of 3H-noradrenaline in adrenergic nerve terminals after reserpine and axotomy. Europ. J. Pharmacol, (in press) (1970b).

    Google Scholar 

  • Häggendal, J., Malmfors, T.: The effect of nerve stimulation on actecholeamines taken up in adrenergic nerves after reserpine pretreatment. Acta physiol. scand. 75, 33–38 (1969).

    Article  PubMed  Google Scholar 

  • Hamberger, B., Levi-Montalcini, R., Norberg, K.-A., Sjöqvist, F.: Monoamines in im-munosympathectomized rats. Int. J. Neuropharmacol. 4, 91–95 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Hamberger, B., Norberg, K.-A.: Studies on some systems of adrenergic synaptic terminals in the abdominal ganglia of the cat. Acta physiol. scand. 65, 235–242 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Hamberger, B., Sjöqvist, F.: Correlated studies of monoamines and acetylcholinesterase in sympathetic ganglia, illustrating the distribution of adrenergic and cholinergic neurons. In: Pharmacology of Cholinergic and Adrenergic Transmission (G. B. Koelle, W. W. Douglas and A. Carlsson), vol. 3, p. 41–54. Oxford: Pergamon Press 1965.

    Google Scholar 

  • Hedqvist, P.: Modulating effect of prostaglandin E2 on noradrenaline release from isolated cat spleen. Acta physiol. scand. 75, 511–512 (1969a).

    Article  PubMed  CAS  Google Scholar 

  • Hedqvist, P.: Antagonism between prostaglandin E2 and phenoxybenzamine on noradrenaline release from the cat spleen. Acta physiol. scand. 76, 383–384 (1969b).

    Article  PubMed  CAS  Google Scholar 

  • Hillarp, N.-Å.: Structure of the synapse and the peripheral innervation apparatus of the autonomic nervous system. M. D. Thesis, Acta anat. (Basel) 2, Suppl. 4, 1–153 (1946).

    Article  Google Scholar 

  • Hillarp, N.-Å.: The construction and functional organization of the autonomic innervation apparatus. Acta physiol. scand. 46, Suppl. 157, 1–38 (1959).

    Google Scholar 

  • Hillarp, N.-Å., Fuxe, K., Dahlström, A.: Central monoamine neurons. In: Mechanisms on release of biogenic amines (U.S. v. Euler, S. Rosell and B. Uvnäs, eds.), p. 31–37. Pergamon Press 1966.

    Google Scholar 

  • Hillarp, N.-Å., Nilson, B.: The structure of the adrenaline and noradrenaline containing granules in the adrenal medullary cells with reference to the storage and release of the sympathomimetic amines. Acta physiol. scand. 31, Suppl. 113, 79–107 (1954).

    CAS  Google Scholar 

  • Holtz, P., Credner, K., Kroneberg, G.: Über das sympathicomimetische pressorische Prinzip des Harns (Urosympathin). Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 204, 228–243 (1947).

    Article  CAS  Google Scholar 

  • Holtz, P., Heise, R., Ludtke, K.: Fermentativer Abbau von 1-dioxyphenylalanin (DOPA) durch die Niere. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 191, 87–118 (1938).

    Article  CAS  Google Scholar 

  • Hydén, H.: The neuron. In: The Cell (J. Brachet and A. Mirsky, eds.), vol. IV, p. 215–323. New York-London : Academic Press 1960.

    Google Scholar 

  • Hökfelt, T.: In vitro studies on central and peripheral monoamine neurons at the ultra-structural level. Z. Zellforsch. 91, 1–74 (1968).

    Article  PubMed  Google Scholar 

  • Hökfelt, T.: Distribution of noradrenaline storage particles in peripheral adrenergic neurons as revealed by electron microscopy. Acta physiol. scand. 76, 427–440 (1969).

    Article  PubMed  Google Scholar 

  • Iggo, A., Vogt, M.: Preganglionic sympathetic activity in normal and in reserpine-treated cats. J. Physiol. (Lond.) 150, 114–133 (1960).

    CAS  Google Scholar 

  • Iversen, L. L.: The uptake and storage of noradrenaline in sympathetic adrenergic nerves. London: Cambridge University Press 1967.

    Google Scholar 

  • Kapeller, K., Mayor, D.: Accumulation of noradrenaline proximal to the site of constriction of sympathetic nerves. J. Physiol. (Lond.) 182, 44–45 P (1965).

    Google Scholar 

  • Kapeller, K., Mayor, D.:Ultrastructural changes proximal to a constriction in sympathetic axons during first 24 hours after operation. J. Anat. (Lond.) 100, 439–441 (1966).

    Google Scholar 

  • Kapeller, K., Mayor, D.: The accumulation of noradrenaline in constricted sympathetic nerves as studied by fluorescence and electron microscopy. Proc. roy. Soc. B 167, 282–292 (1967).

    Article  CAS  Google Scholar 

  • Karlsson, J.-O., Sjfestrand, J.: The effect of colchicine on the axonal transport of protein in the optic nerve and tract of the rabbit. Brain Res. 13, 617–619 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Katz, B.: The transmission of impulses from nerve to muscle, and the subcellular unit of synaptic action. Proc. roy. Soc. B 155, 455–479 (1962).

    Article  Google Scholar 

  • Kaufmann, S., Friedman, S.: Dopamine-β-hydroxylase. Pharmacol. Rev. 17, 71–100 (1965).

    Google Scholar 

  • Kirshner, N., Sage, H. J., Smith, W. J., Kirshner, A. G.: Release of catecholamines and specific protein from adrenal glands. Science 154, 529–531 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Kreutzberg, G.: Neuronal dynamics and axonal flow. IV. Blockage of intra-axonal enzyme transport by colchicine. Proc. nat. Acad. Sci. (Wash.) 62, 722–728 (1969).

    Article  CAS  Google Scholar 

  • Laduron, P., Belpaire, F.: Transport of noradrenaline and dopamines-hydroxylase in sympathetic nerves. Life. Sci. 7, 1–7 (1968 a).

    Article  PubMed  CAS  Google Scholar 

  • Laduron, P., Belpaire, F.: Evidence for an extragranular localization of tyrosine hydroxylase. Nature (Lond.) 217, 1155–1156 (1968b).

    Article  CAS  Google Scholar 

  • Langley, J. N.: The sympathetic and other related systems of nerves. Textbook of physiology (E. A. Schäfer, ed.), vol. 2, p. 616–696, 1900.

    Google Scholar 

  • Laties, A., Jacobowitz, A.: A comparative study of the autonomic innervation of the eye in monkey, cat and rabbit. Anat. Rec. 156, 383–396 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Levi-Montalcini, R.: The nerve growth factor. Ann. N.Y. Acad. Sci. 118, 149–170 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Livett, B. G., Geffen, L. B., Austin, L.: Proximo-distal transport of 14C-noradrenaline and protein in sympathetic nerves. J. Neurochem. 15, 931–939 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Loewi, O.: Über humorale Übertragbarkeit der Herznervenwirkung. Pflügers Arch. ges. Physiol. 189, 239–242 (1921).

    Article  Google Scholar 

  • Lubińska, L.: Axoplasmic streaming in regenerating and in normal nerve fibres. In: Mechanisms of Neuronal Regeneration. Progr. brain res. (M. Singer and J. P. Schade, eds.), vol. 13, p. 1–71. Amsterdam: Elsevier Publishing Co. 1964.

    Google Scholar 

  • Malmfors, T.: Studies on adrenergic nerves. The use of rat and mouse iris for direct observations on their physiology and pharmacology at cellular and subcellular levels. Acta physiol. scand. 64, Suppl. 248, 1–93 (1965).

    Google Scholar 

  • Malmfors, T., Sachs, C.: Direct studies on the disappearance of the transmitter and the changes in the uptake-storage mechanisms of degenerating adrenergic nerves. Acta physiol. scand. 64, 211–223 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Mann, M., West, G. B.: The nature of hepatic and splenic sympathin. Brit. J. Pharmacol. 5, 173–177 (1950).

    PubMed  CAS  Google Scholar 

  • Mann, M., West, G. B.: The nature of uterine and intestinal sympathin. Brit. J. Pharmacol. 5, 173–177 (1951).

    Google Scholar 

  • McLean, J. R., Bell, C, Burnstock, G.: Histochemical and pharmacological studies of the innervation of the urinary bladder of the frog. (Rana temporaria).Comp. Biochem. Physiol. 21, 383–392 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Norberg, K.-A.: Transmitter histochemistry of the sympathetic adrenergic nervous system. Brain Res. 5, 125–170 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Norberg, K.-A., Hamberger, B.: The sympathetic adrenergic neuron. Some characteristics revealed by histochemical studies on the intraneuronal distribution of the transmitter. Acta physiol. scand. 63, Suppl. 238, 1–42 (1964).

    Google Scholar 

  • Olson, L.: Outgrowth of sympathetic adrenergic neurons in mice treated with a nerve-growth factor (NGF). Z. Zellforsch. 81, 155–173 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Olson, L.: Unpublished observations (1968).

    Google Scholar 

  • Outschoorn, A. S.: The hormones of the adrenal medulla and their release. Brit. J. Pharmacol. 7, 605–615 (1952).

    PubMed  CAS  Google Scholar 

  • Outschoorn, A. S., Vogt, M.: The nature of cardiac sympathin in the dog. Brit. J. Pharmacol. 7, 319–324 (1952).

    PubMed  CAS  Google Scholar 

  • Peart, W. S.: The nature of splenic sympathin. J. Physiol. (Lond.) 108, 491–501 (1949).

    Google Scholar 

  • Richardson, K. C.: Electron microscopic identification of autonomic nerve endings. Nature (Lond.) 210, 756 (1966).

    Article  CAS  Google Scholar 

  • Schmiterlöv, C. G.: The nature and occurrence of pressor and depressor substances in extracts from blood vessels. Acta physiol. scand. 16, Suppl. 56 (1948).

    Google Scholar 

  • Schmitt, P. O.: The molecular biology of neural fibrous proteins. Neurosci. Res. Progr. Bull. 6, 119–144 (1968).

    Google Scholar 

  • Sedvall, G.: Noradrenaline storage in skeletal muscle. Acta physiol. scand. 60, 39–50 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Stjärne, L., Hedqvist, P., Bygdeman, S.: Neurotransmitter quantum released from sympathetic nerves in cat’s skeletal muscle. Life Sci. 8, 189–196 (1969).

    Article  PubMed  Google Scholar 

  • Twarog, B. M., Page, I. H.: Serotonin content of some mammalian tissues and urine and methods for its determination. Amer. J. Physiol. 175, 157–161 (1953).

    PubMed  CAS  Google Scholar 

  • Weiss, P.: The concept of perpetual neuronal growth and proximo-distal substance convection. In: Regional Neurochemistry (S. S. Kety and J. Elkes, eds.), p. 220. New York: Pergamon Press 1961.

    Google Scholar 

  • Weiss, P., Hiscoe, H.: Experimentais on the mechanism of nerve growth. J. exp. Zool. 107, 315–396 (1948).

    Article  PubMed  CAS  Google Scholar 

  • West, G. B.: Further studies on sympathin. Brit. J. Pharmacol. 5, 165–172 (1950).

    PubMed  CAS  Google Scholar 

  • Wirsen, C.: Distribution of adrenergic nerve fibres in brown and white adipose tissue. In: Handbook of physiology (A. E. Renold and C. F. Cahill, eds.), sect. 5, Adipose Tissue. Baltimore 1965.

    Google Scholar 

  • Vogt, M.: The concentration of sympathin in different parts of the central nervous system under normal conditions and after the administration of drugs. J. Physiol. (Lond.) 123, 451–481 (1954).

    CAS  Google Scholar 

  • Zaimis, E., Berk, L., Callingham, B.: Morphological, biochemical and functional changes in the sympathetic nervous system of rats treated with NGF-antiserum. Nature (Lond.) 206, 1221–1222 (1965).

    Article  Google Scholar 

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Dahlström, A. (1970). Adrenergic Neurons in Mammals with Special Reference to Fluorescence Microscopical Studies. In: Bargmann, W., Scharrer, B. (eds) Aspects of Neuroendocrinology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46207-8_6

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