Skip to main content

Optic Nerve Tumors

  • Chapter
  • First Online:
Clinical Ophthalmic Oncology

Abstract

Primary tumors of the optic nerve include anterior visual pathway gliomas and optic nerve sheath meningiomas. Both are relatively rare lesions that result in significant visual morbidity. Together they account for less than 4 % of all orbital tumors. There has been controversy about the natural history and appropriate management of these lesions, resulting from small sample sizes and short follow-up periods. Other tumors, such as gangliogliomas and primary lymphomas, have also been described but are extremely rare.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Dutton JJ. Gliomas of the anterior visual pathway. Surv Ophthalmol. 1994;38:427–52.

    Article  PubMed  CAS  Google Scholar 

  2. Shields JA, Shields CL, Scartozzi R. Survey of 1264 patients with orbital tumors and simulating lesions: the 2002 Montgomery Lecture, part I. Ophthalmology. 2004;111:997–1008.

    Article  PubMed  Google Scholar 

  3. Binning MJ, Liu JK, Kestle JR, et al. Optic pathway gliomas: a review. Neurosurg Focus. 2007;23:E2.

    Article  PubMed  Google Scholar 

  4. Astrup J. Natural history and clinical management of optic pathway gliomas. Br J Neurosurg. 2003;17:327–35.

    Article  PubMed  CAS  Google Scholar 

  5. Czyzyk E, Jozwiak S, Roszkowski M, Schwartz RA. Optic pathway gliomas in children with and without neurofibromatosis 1. J Child Neurol. 2003;18:471–8.

    Article  PubMed  Google Scholar 

  6. Grill J, Laithier V, Raquin MA, et al. When do children with optic pathway tumors need treatment? An oncological perspective in 106 patients treated in a single center. Eur J Pediatr. 2000;159:692–6.

    Article  PubMed  CAS  Google Scholar 

  7. Singhal D, Birch JM, Kerr B, et al. Neurofibromatosis type 1 and sporadic gliomas. Arch Dis Child. 2002;87:65–70.

    Article  PubMed  CAS  Google Scholar 

  8. Shamji MF, Benoit BG. Syndromic and sporadic pediatric optic pathway gliomas: review of clinical and histopathological differences and treatment implications. Neurosurg Focus. 2007;23:E3.

    Article  PubMed  Google Scholar 

  9. Thiagalingam S, Flaharty M, Billson F, North K. Neurofibromatosis type 1 and optic pathway gliomas: follow-up of 54 patients. Ophthalmology. 2004;111:568–77.

    Article  PubMed  Google Scholar 

  10. Segal L, Darvish-Zargar M, Dilenge ME, et al. Optic pathway gliomas in patients with neurofibromatosis type 1: follow-up of 44 patients. J AAPOS. 2010;14:155–8.

    Article  PubMed  Google Scholar 

  11. Lee AG, Dutton JJ. A practice pathway for the management of gliomas of the anterior visual pathway: an update ad an evidenced-based approach. Neuro-ophthalmology. 1999;22:139–55.

    Article  Google Scholar 

  12. Glaser JS, Hoyt WF, Corbett J. Visual morbidity with chiasmal glioma. Long-term studies of visual fields in untreated and irradiated cases. Arch Ophthalmol. 1971;85:3–12.

    Article  PubMed  CAS  Google Scholar 

  13. Hoyt WF, Bagdassarian SA. Optic gliomas of childhood: natural history and rationale for conservative management. Br J Ophthalmol. 1969;53:793–8.

    Article  PubMed  CAS  Google Scholar 

  14. Tow SL, Chandela S, Miller NR, Avellino AM. Long-term outcome in children with gliomas of the anterior visual pathway. Pediatr Neurol. 2003;28:262–70.

    Article  PubMed  Google Scholar 

  15. Mikaeloff Y, Chaix Y, Grill J, et al. Optic pathway gliomas in neurofibromatosis type 1. Longitudinal study of 30 cases in two multidisciplinary practices. Arch Pediatr. 2002;9:797–804.

    Article  PubMed  CAS  Google Scholar 

  16. Khafaga Y, Hassounah M, Kandil A, et al. Optic gliomas: a retrospective analysis of 50 cases. Int J Radiat Oncol Biol Phys. 2003;56:807–12.

    Article  PubMed  Google Scholar 

  17. Combs SE, Schulz-Ertner D, Moschos D, et al. Fractionated stereotactic radiotherapy of optic pathway gliomas: tolerance and long-term outcome. Int J Radiat Oncol Biol Phys. 2005;62:814–9.

    Article  PubMed  Google Scholar 

  18. Aquno VM, Fort DW, Kamen BA. Carboplatin for the treatment of children with newly diagnosed optic chiasm gliomas: a phase II study. J Neurooncol. 1999;41:255–9.

    Article  Google Scholar 

  19. Silva MM, Goldman S, Keating G, et al. Optic pathway hypothalamic gliomas in children under three years of age: the role of chemotherapy. Pediatr Neurosurg. 2000;33:151–8.

    Article  PubMed  CAS  Google Scholar 

  20. Hsu TR, Wong TT, Chang FC, et al. Responsiveness of progressive optic pathway tumors to cisplatin-based chemotherapy in children. Childs Nerv Syst. 2008;24:1457–61.

    Article  PubMed  Google Scholar 

  21. Kelly JP, Leary S, Khanna P, Weiss AH. Longitudinal measures of visual function, tumor volume, and prediction of visual outcomes after treatment of optic pathway gliomas. Ophthalmology. 2012;119:1231–7.

    Article  PubMed  Google Scholar 

  22. Zoeller GK, Brathwaite CD, Sandberg DI. Malignant transformation of an optic pathway glioma without prior radiation therapy. J Neurosurg Pediatr. 2010;5:507–10.

    Article  PubMed  Google Scholar 

  23. Parsa CF, Hoyt CS, Lesser RL, et al. Spontaneous regression of optic gliomas: thirteen cases documented by serial neuroimaging. Arch Ophthalmol. 2001;119:516–29.

    Article  PubMed  CAS  Google Scholar 

  24. Hoyt WF, Meshel LG, Lessell S, et al. Malignant optic glioma of adulthood. Brain. 1973;96:121–32.

    Article  PubMed  CAS  Google Scholar 

  25. Wabbels B, Demmier A, Seitz J, et al. Unilateral adult malignant optic nerve glioma. Graefes Arch Clin Exp Ophthalmol. 2004;242:741–8.

    Article  PubMed  Google Scholar 

  26. Dario A, Iadini A, Cerati M, Marra A. Malignant optic glioma of adulthood. Case report and review of the literature. Acta Neurol Scand. 1999;100:350–3.

    Article  PubMed  CAS  Google Scholar 

  27. Dutton JJ. Optic nerve sheath meningiomas. Surv Ophthalmol. 1992;37:167–83.

    Article  PubMed  CAS  Google Scholar 

  28. Miller NR. New concepts in the diagnosis and management of optic nerve sheath meningioma. J Neuroophthalmol. 2006;26(3):200–8.

    Article  PubMed  Google Scholar 

  29. Yuceer N, Erdogan A, Ziya H. Primary optic nerve sheath meningiomas. Report of seven cases (clinical neuroradiological, pathological and surgical considerations in seven cases). J Neurosurg Sci. 1994;38:155–9.

    PubMed  CAS  Google Scholar 

  30. Cristante L. Surgical treatment of meningiomas of the orbit and optic canal: a retrospective study with particular attention to the visual outcome. Acta Neurol (Wien). 1994;126:27–32.

    Article  CAS  Google Scholar 

  31. Norris JH, Norris JS, Akinwunmi J, Malhotra R. Optic canal decompression with dural sheath release: a combined orbito-cranial approach to preserving sigh from tumours invading the optic canal. Orbit. 2010;31:34–43.

    Article  Google Scholar 

  32. Pacelli R, Cella L, Conson M, et al. Fractionated stereotactic radiation therapy for orbital optic nerve sheath meningioma – a single institution experience and a short review of the literature. J Radiat Res. 2011;52:82–7.

    Article  PubMed  Google Scholar 

  33. Abouaf L, Girard N, Lefort T, et al. Standard-fractionated radiotherapy for optic nerve sheath meningioma: visual outcome is predicted by mean eye dose. Int J Radiat Oncol Biol Phys. 2012;82:1268–77.

    Article  PubMed  Google Scholar 

  34. Narayan S, Cornblath WT, Sandler HM. Preliminary visual outcomes after three-dimensional conformal radiation therapy for optic nerve sheath meningioma. Int J Radiat Oncol Biol Phys. 2003;56:537–43.

    Article  PubMed  Google Scholar 

  35. Romanelli P, Bianchi L, Muacevic A, Beltramo G. Staged image guided robotic radiosurgery for optic nerve sheath meningiomas. Comput Aided Surg. 2011;16:257–66.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jonathan J. Dutton .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Dutton, J.J. (2014). Optic Nerve Tumors. In: Perry, J., Singh, A. (eds) Clinical Ophthalmic Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40492-4_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-40492-4_9

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-40491-7

  • Online ISBN: 978-3-642-40492-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics