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Responsiveness of progressive optic pathway tumors to cisplatin-based chemotherapy in children

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Abstract

Background

Though the pathology of optic pathway tumor is mostly pilocytic astrocytoma, the benign tumor behaves like malignant tumor because total resection is not feasible. Adjuvant chemotherapy might be a reasonable strategy for management of these low grade tumors which keep growing. We evaluate the responsiveness of optic pathway tumor to cisplatin-based chemotherapy.

Methods

Patients with unresectable and progressive optic pathway tumors received conventional chemotherapy including cisplatin, etoposide, and vinblastine were enrolled in this study from 1992 to 2007. Patients treated with radiotherapy previously were excluded. Brain MRI was performed every 3 months to evaluate the objective response to chemotherapy.

Results

There are seven girls and nine boys enrolled in this study. The median age at diagnosis was 30 months old (range from 3 months to 11 years old). The median follow-up duration was 81.5 months (range from 24 months to 14.5 years). The pathology showed pilocytic astrocytomas in 11 patients, astrocytoma in one patient, and anaplastic astrocytomas in two patients. The 6-month progression-free survival (PFS) is 100%, 12-month PFS is 81.3%, 3-year PFS is 71.4% and 5-year PFS is 55.5% respectively. The toxicity of the cisplatin-based chemotherapy showed mild bone marrow suppression in 13 patients (81.3%), infection in nine patients (56.3%), gastrointestinal discomfort in seven patients (43.8%), renal insufficiency in two patient (12.5%), cerebral salt wasting syndrome with hyponatremia in one patient (6.25%) and high pitch hearing loss in two patients (12.5%).

Conclusion

Cisplatin-based chemotherapy is an effective regimen for control of progressive optic pathway tumors.

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Authors and Affiliations

  1. Department of Pediatrics, National Yang-Ming University Hospital, 152, Xin Min Rd, I-Lan, 26042, Taiwan, Republic of China

    Ting-Rong Hsu & Peck-Foong Thien

  2. Faculty of Medicine, National Yang-Ming University, 155, Li-Long St. Sec. 2, Shih-Pai, Taipei, Taiwan, Republic of China

    Ting-Rong Hsu, Tai-Tong Wong, Feng-Chi Chang & Donald M. Ho

  3. Department of Pediatrics, Taipei Veterans General Hospital, 201, Sec 2, Shih-Pai Road, Taipei, 112, Taiwan, Republic of China

    Ting-Rong Hsu, Ren-Bin Tang & Kai-Ping Chang

  4. Pediatric Neurosurgery Division, Neurological Institute, Taipei Veterans General Hospital, 201, Sec 2, Shih-Pai Road, Taipei, 112, Taiwan, Republic of China

    Tai-Tong Wong

  5. Radiology Department, Taipei Veterans General Hospital, 201, Sec 2, Shih-Pai Road, Taipei, 112, Taiwan, Republic of China

    Feng-Chi Chang

  6. Pathology and Laboratory Medicine Department, Taipei Veterans General Hospital, 201, Sec 2, Shih-Pai Road, Taipei, 112, Taiwan, Republic of China

    Donald M. Ho

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  1. Ting-Rong Hsu
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Correspondence to Kai-Ping Chang.

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Ting-Rong Hsu and Kai-Ping Chang contributed equally to this paper.

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Hsu, TR., Wong, TT., Chang, FC. et al. Responsiveness of progressive optic pathway tumors to cisplatin-based chemotherapy in children. Childs Nerv Syst 24, 1457–1461 (2008). https://doi.org/10.1007/s00381-008-0707-4

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  • DOI: https://doi.org/10.1007/s00381-008-0707-4

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