Abstract
The most commonly encountered malignancy of the lips, especially the lower lip, is of epithelial origin, specifically squamous cell carcinoma. Cancer of the lip represents the second most common malignancy of the head and neck and accounts for approximately 25–30 % of the oral cavity tumors. Malignant tumors of mesenchymal origin as well as those originating from salivary gland tissue although overall rare can be found in the lips. While epithelial cancers are twice as common in men as in women, have clear association with sun exposure, and are found mainly in the lower lip, the incidence and etiology of other malignancies are less clear. In this chapter we will discuss the most common non-epithelial origin malignancies that can be found in the lips as well as their management.
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References
Hasson O (2008) Squamous cell carcinoma of the lower lip. J Oral Maxillofac Surg 66(6):1259–1262
MacIntosh R (1995) Minor salivary gland tumors: types, incidence and management. Oral Maxillofac Surg Clin N Am 7:573–589
Carlson EO, Ord RA (2008) Tumors of the minor salivary glands. In: Carlson EO, Ord RA (eds) Textbook and color atlas of salivary gland pathology, vol 1, 1st edn. Wiley-Blackwell, Ames
Pires FR et al (2006) Intra-oral minor salivary gland tumors: a clinicopathological study of 546 cases. Oral Oncol 43(5):463–470
Regezi JA et al (1985) Minor salivary gland tumors. A histologic and immunohistochemical study. Cancer 55(1):108–115
Eveson JCR (1984) Salivary gland tumors. A review of 2410 cases with particular reference to histological types, site, age and sex distribution. J Pathol 146:51–58
Spiro RH (1986) Salivary neoplasms: overview of a 35-year experience with 2,807 patients. Head Neck Surg 8(3):177–184
Chau MN, Radden BG (1986) Intra-oral salivary gland neoplasms: a retrospective study of 98 cases. J Oral Pathol 15(6):339–342
Isacsson G, Shear M (1983) Intraoral salivary gland tumors: a retrospective study of 201 cases. J Oral Pathol 12(1):57–62
Jaber MA (2006) Intraoral minor salivary gland tumors: a review of 75 cases in a Libyan population. Int J Oral Maxillofac Surg 35(2):150–154
Lopes MA et al (1999) A clinicopathologic study of 196 intraoral minor salivary gland tumours. J Oral Pathol Med 28(6):264–267
Potdar GG, Paymaster JC (1969) Tumors of minor salivary glands. Oral Surg Oral Med Oral Pathol 28(3):310–319
Rivera-Bastidas H, Ocanto RA, Acevedo AM (1996) Intraoral minor salivary gland tumors: a retrospective study of 62 cases in a Venezuelan population. J Oral Pathol Med 25(1):1–4
Stuteville OH, Corley RD (1967) Surgical management of tumors of intraoral minor salivary glands. Report of eighty cases. Cancer 20(10):1578–1586
Toida M et al (2005) Intraoral minor salivary gland tumors: a clinicopathological study of 82 cases. Int J Oral Maxillofac Surg 34(5):528–532
Waldron CA, El-Mofty SK, Gnepp DR (1988) Tumors of the intraoral minor salivary glands: a demographic and histologic study of 426 cases. Oral Surg Oral Med Oral Pathol 66(3):323–333
Jansisyanont P, Blanchaert RH Jr, Ord RA (2002) Intraoral minor salivary gland neoplasm: a single institution experience of 80 cases. Int J Oral Maxillofac Surg 31(3):257–261
Neely MM, Rohrer MD, Young SK (1996) Tumors of minor salivary glands and the analysis of 106 cases. J Okla Dent Assoc 86(4):50–52
Yih WY, Kratochvil FJ, Stewart JC (2005) Intraoral minor salivary gland neoplasms: review of 213 cases. J Oral Maxillofac Surg 63(6):805–810
Stewart FW, Foote FW, Becker WF (1945) Muco-epidermoid tumors of salivary glands. Ann Surg 122(5):820–844
Accetta PA (1984) Mucoepidermoid carcinoma of salivary glands. Arch Pathol Lab Med 108(4):321–325
Auclair PL, Goode RK, Ellis GL (1992) Mucoepidermoid carcinoma of intraoral salivary glands. Evaluation and application of grading criteria in 143 cases. Cancer 69(8):2021–2030
Auclair PL, Ellis GL, Gnepp DR, Wenig BM (1991) Salivary gland neoplasms: general considerations. In: Ellis G, Auclair PL, Gnepp DR (eds) Surgical pathology. WB Saunders, Philadelphia
Brandwein MS et al (2001) Mucoepidermoid carcinoma: a clinicopathologic study of 80 patients with special reference to histological grading. Am J Surg Pathol 25(7):835–845
Goode RK, Auclair PL, Ellis GL (1998) Mucoepidermoid carcinoma of the major salivary glands: clinical and histopathologic analysis of 234 cases with evaluation of grading criteria. Cancer 82(7):1217–1224
Healey WV, Perzin KH, Smith L (1970) Mucoepidermoid carcinoma of salivary gland origin. Classification, clinical-pathologic correlation, and results of treatment. Cancer 26(2):368–388
Locati LD (2002) Primary high-grade mucoepidermoid carcinoma of the minor salivary glands with cutaneous metastases at diagnosis. Oral Oncol 38(4):401–404
Nascimento AG (1986) Mucoepidermoid carcinoma of salivary glands: a clinicopathologic study of 46 cases. Head Neck Surg 8(6):409–417
O’Brien CJ (1986) Malignant salivary tumors–analysis of prognostic factors and survival. Head Neck Surg 9(2):82–92
Evans HL (1984) Mucoepidermoid carcinoma of salivary glands: a study of 69 cases with special attention to histologic grading. Am J Clin Pathol 81(6):696–701
Jensen OJ, Poulsen T, Schiodt T (1988) Mucoepidermoid tumors of salivary glands. A long term follow-up study. APMIS 96(5):421–427
Kolokythas A et al (2010) Low-grade mucoepidermoid carcinoma of the intraoral minor salivary glands with cervical metastasis: report of 2 cases and review of the literature. J Oral Maxillofac Surg 68(6):1396–1399
Foote FW Jr, Frazell EL (1953) Tumors of the major salivary glands. Cancer 6(6):1065–1133
Umeda M et al (2000) The role of radiotherapy for patients with adenoid cystic carcinoma of the salivary gland. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 89(6):724–729
Prott FJ et al (2000) Results of fast neutron therapy of adenoid cystic carcinoma of the salivary glands. Anticancer Res 20(5C):3743–3749
Avery CM et al (2000) Combined treatment of adenoid cystic carcinoma of the salivary glands. Int J Oral Maxillofac Surg 29(4):277–279
Bianchi B et al (2008) Adenoid cystic carcinoma of intraoral minor salivary glands. Oral Oncol 44(11):1026–1031
Bobbio A et al (2008) Lung metastasis resection of adenoid cystic carcinoma of salivary glands. Eur J Cardiothorac Surg 33(5):790–793
Ciccolallo L et al (2009) Survival from salivary glands adenoid cystic carcinoma in European populations. Oral Oncol 45(8):669–674
Enamorado I et al (2004) Correlation of histopathological variants, cellular DNA content, and clinical outcome in adenoid cystic carcinoma of the salivary glands. Otolaryngol Head Neck Surg 131(5):646–650
Huang M et al (1997) Factors influencing survival rate in adenoid cystic carcinoma of the salivary glands. Int J Oral Maxillofac Surg 26(6):435–439
Ampil FL, Misra RP (1987) Factors influencing survival of patients with adenoid cystic carcinoma of the salivary glands. J Oral Maxillofac Surg 45(12):1005–1010
Rice DH (1981) Adenoid cystic carcinoma of the minor salivary glands: long-term survival with planned combined therapy. Arch Otolaryngol 107(2):128
Fernandes RP, Ord R (2009) Chapter 26, Salivary gland disease. In: Fonseca R, Marciani RD, Turvey T (eds) Oral and maxillofacial surgery, vol 2. Saunders an imprint of Elsevier, St Louis
Marx R, Stern D (2003) Salivary gland neoplasms. In: Marx R, Stern D (eds) Oral and maxillofacial pathology. A rational for diagnosis and treatment, vol 1. Quintessence Publishing Co, Inc, Chicago
Regezi J, Sciubba JJ, Jordan RCK (2003) Salivary gland disease. In: Regezi S, Jordan RCK (eds) Oral pathology- clinical pathologic correlations, vol 1, 4th edn. Elsevier, Missouri
Wenig B (2008) Neoplasms of the salivary glands. In: Wenig B (ed) Atlas of head and neck pathology, vol 1. Saunders an imprint of Elsevier, inc, Philadelphia
Huber PE et al (2001) Radiotherapy for advanced adenoid cystic carcinoma: neutrons, photons or mixed beam? Radiother Oncol 59(2):161–167
van Heerden WF, Raubenheimer EJ (1991) Intraoral salivary gland neoplasms: a retrospective study of seventy cases in an African population. Oral Surg Oral Med Oral Pathol 71(5):579–582
Curran AE et al (2001) Polymorphous low-grade adenocarcinoma versus pleomorphic adenoma of minor salivary glands: resolution of a diagnostic dilemma by immunohistochemical analysis with glial fibrillary acidic protein. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91(2):194–199
Epivatianos A et al (2005) Adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of minor salivary glands: a comparative immunohistochemical study using the epithelial membrane and carcinoembryonic antibodies. Oral Dis 11(3):175–180
Evans HL, Batsakis JG (1984) Polymorphous low-grade adenocarcinoma of minor salivary glands. A study of 14 cases of a distinctive neoplasm. Cancer 53(4):935–942
Frierson HF Jr, Mills SE, Garland TA (1985) Terminal duct carcinoma of minor salivary glands. A nonpapillary subtype of polymorphous low-grade adenocarcinoma. Am J Clin Pathol 84(1):8–14
Nagao T et al (2004) Polymorphous low-grade adenocarcinoma of the major salivary glands: report of three cases in an unusual location. Histopathology 44(2):164–171
Perez-Ordonez B, Linkov I, Huvos AG (1998) Polymorphous low-grade adenocarcinoma of minor salivary glands: a study of 17 cases with emphasis on cell differentiation. Histopathology 32(6):521–529
Simpson RH et al (2002) Polymorphous low-grade adenocarcinoma of the salivary glands with transformation to high-grade carcinoma. Histopathology 41(3):250–259
Loducca SV et al (2000) Polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma: distinct architectural composition revealed by collagen IV, laminin and their integrin ligands (alpha2beta1 and alpha3beta1). Histopathology 37(2):118–123
Triantafillidou K et al (2010) Acinic cell carcinoma of minor salivary glands: a clinical and immunohistochemical study. J Oral Maxillofac Surg 68(10):2489–2496
Omlie JE, Koutlas IG (2010) Acinic cell carcinoma of minor salivary glands: a clinicopathologic study of 21 cases. J Oral Maxillofac Surg 68(9):2053–2057
Baxter H, Review A (1941) A review of malignant melanoma of the mouth. Am J Surg L1(2):379–386
Lourenco SV et al (2009) Primary oral mucosal melanoma: a series of 35 new cases from South America. Am J Dermatopathol 31(4):323–330
Kruse AL et al (2010) Mucosal malignant melanomas in head and neck surgery: a retrospective study of six patients and review of the literature. Oral Maxillofac Surg 14(3):143–147
Meleti M et al (2007) Oral malignant melanoma: the Amsterdam experience. J Oral Maxillofac Surg 65(11):2181–2186
Meleti M et al (2007) Oral malignant melanoma: a review of the literature. Oral Oncol 43(2):116–121
Froix AJ, Salti GI (2003) Primary malignant melanoma of the lip. J Surg Oncol 84(1):7–9
Wang X et al (2011) Primary oral mucosal melanoma: advocate a wait-and-see policy in the clinically N0 patient. J Oral Maxillofac Surg 70(5):1192–1198
Sortino-Rachou AM et al (2009) Primary oral melanoma: population-based incidence. Oral Oncol 45(3):254–258
Prasad ML et al (2002) Prognostic factors for malignant melanoma of the squamous mucosa of the head and neck. Am J Surg Pathol 26(7):883–892
Patel SG et al (2002) Primary mucosal malignant melanoma of the head and neck. Head Neck 24(3):247–257
Papadopoulos T, Thompson JF, Quinn MJ (1996) Melanoma of the lip. Aust N Z J Surg 66(5):327–330
Ghouri A et al (1994) Primary malignant melanoma of the lower lip. Iowa Med 84(11):497–500
Liversedge RL (1975) Oral malignant melanoma. Br J Oral Surg 13(1):40–55
Hessel AC, Byers RM (2002) Desmoplastic melanoma of the lip. Head Neck 24(6):605–608
Guo J et al (2011) Phase II open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification. J Clin Oncol 29(21):2904–2909
Young K, Minchom A, Larkin J (2012) BRIM-1, -2 and −3 trials: improved survival with vemurafenib in metastatic melanoma patients with a BRAF(V600E) mutation. Future Oncol 8(5):499–507
Chapman PB et al (2011) Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 364(26):2507–2516
Eggermont AM, Robert C (2011) New drugs in melanoma: it’s a whole new world. Eur J Cancer 47(14):2150–2157
Temam S et al (2005) Postoperative radiotherapy for primary mucosal melanoma of the head and neck. Cancer 103(2):313–319
Parsons WH, Henthorne JC (1944) Extraskeletal osteogenic sarcoma : report of a case of osteogenic sarcoma of the lip. Ann Surg 119(4):595–601
Arribas-Garcia I et al (2008) Oral primary angiosarcoma of the lower lip mucosa: report of a case in a 15-year-old boy. Head Neck 30(10):1384–1388
Patterson H et al (1998) Lip, a human gene detected by transfection of DNA from a human liposarcoma encodes a protein with homology to regulators of small g proteins. Sarcoma 2(1):35–44
Sobral AP et al (2007) Myxoid liposarcoma of the lip: correlation of histological and cytological features and review of the literature. J Oral Maxillofac Surg 65(8):1660–1664
Cholnocky TD (1934) Round-cell, spindle-cell, and neurogenic sarcomas of the lip. Am J Cancer 22:548–554
Vandeweyer E, Seyeidi JV, Deraemaecker R (1997) Dermatofibrosarcoma protuberans of the upper lip: an overview and a case report. Eur J Surg Oncol 23(3):275–277
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Kolokythas, A. (2014). Non-epidermoid Malignancies of the Lips. In: Kolokythas, A. (eds) Lip Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38180-5_14
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DOI: https://doi.org/10.1007/978-3-642-38180-5_14
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