Abstract
Introduction
Of all malignant processes of the oral mucosa, 0.5% are malignant melanomas. Because of late diagnosis, pattern of growth, close proximity to the bone (particularly in palatinal localizations), and the correlated infiltration, malignant melanomas have a bad prognosis.
Patients and methods
In this retrospective study, six cases of patients with oral mucosal malignant melanoma are evaluated, and a critical review of the literature is presented. The female to male proportion was 1:1 with an average age of 60.2 years; all patients were treated between January 1999 and July 2007. A neck dissection was performed on two patients because of clinically positive lymph nodes; one patient received interleukin 2 therapy, and three patients received postoperative radiotherapy. Two male patients died.
Conclusions
We recommend biopsy on every growing lesion, pigmented or nonpigmented, for the required diagnosis and, in cases of malignant melanoma, wide excision as a second step. Neck dissections should be performed in patients with clinically positive lymph nodes. Concerning interleukin 2 therapy, further studies should be performed in order to evaluate a routine application.
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References
Chang AE, Karnell LH, Menck HR (1998) The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84, 836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer 83(8):1664–1678
Rapini RP et al (1985) Primary malignant melanoma of the oral cavity. A review of 177 cases. Cancer 55(7):1543–1551
Femiano F et al (2008) Oral malignant melanoma: a review of the literature. J Oral Pathol Med 37(7):383–388
Garzino-Demo P et al (2004) Oral mucosal melanoma: a series of case reports. J Craniomaxillofac Surg 32(4):251–257
Hicks MJ, Flaitz CM (2000) Oral mucosal melanoma: epidemiology and pathobiology. Oral Oncol 36(2):152–169
Gu GM, Epstein JB, Morton TH Jr (2003) Intraoral melanoma: long-term follow-up and implication for dental clinicians. A case report and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 96(4):404–413
Meleti M et al (2007) Oral malignant melanoma: a review of the literature. Oral Oncol 43(2):116–121
Notani K et al (2002) Amelanotic malignant melanomas of the oral mucosa. Br J Oral Maxillofac Surg 40(3):195–200
Prasad ML et al (2003) Clinicopathologic differences in malignant melanoma arising in oral squamous and sinonasal respiratory mucosa of the upper aerodigestive tract. Arch Pathol Lab Med 127(8):997–1002
Greene GW et al (1953) Primary malignant melanoma of the oral mucosa. Oral Surg Oral Med Oral Pathol 6(12):1435–1443
Prasad ML et al (2004) Primary mucosal melanoma of the head and neck: a proposal for microstaging localized, stage I (lymph node-negative) tumors. Cancer 100(8):1657–1664
Tanaka N et al (2004) Primary malignant melanoma of the oral cavity: assessment of outcome from the clinical records of 35 patients. Int J Oral Maxillofac Surg 33(8):761–765
Rapini RP (1997) Oral melanoma: diagnosis and treatment. Semin Cutan Med Surg 16(4):320–322
Rogers RS 3rd, Gibson LE (1997) Mucosal, genital, and unusual clinical variants of melanoma. Mayo Clin Proc 72(4):362–366
Lens MB, Nathan P, Bataille V (2007) Excision margins for primary cutaneous melanoma: updated pooled analysis of randomized controlled trials. Arch Surg 142(9):885–891, discussion 891–893
Thompson LD, Wieneke JA, Miettinen M (2003) Sinonasal tract and nasopharyngeal melanomas: a clinicopathologic study of 115 cases with a proposed staging system. Am J Surg Pathol 27(5):594–611
Yii NW et al (2003) Mucosal malignant melanoma of the head and neck: the Marsden experience over half a century. Clin Oncol (R Coll Radiol) 15(4):199–204
Patel SG et al (2002) Primary mucosal malignant melanoma of the head and neck. Head Neck 24(3):247–257
Gorsky M, Epstein JB (1998) Melanoma arising from the mucosal surfaces of the head and neck. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 86(6):715–719
Bong JL, Herd RM, Hunter JA (2002) Incisional biopsy and melanoma prognosis. J Am Acad Dermatol 46(5):690–694
Lederman JS, Sober AJ (1985) Does biopsy type influence survival in clinical stage I cutaneous melanoma? J Am Acad Dermatol 13(6):983–987
Mendenhall WM et al (2005) Head and neck mucosal melanoma. Am J Clin Oncol 28(6):626–630
Barker BF et al (1997) Oral mucosal melanomas: the WESTOP Banff workshop proceedings. Western Society of Teachers of Oral Pathology. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 83(6):672–679
Mohr P, Weichenthal M, Hauschild A (2003) Adjuvant therapy in melanoma. Onkologie 26(3):227–233
Verma S et al (2006) Systematic review of systemic adjuvant therapy for patients at high risk for recurrent melanoma. Cancer 106(7):1431–1442
Petrella T et al (2007) Single-agent interleukin-2 in the treatment of metastatic melanoma: a systematic review. Cancer Treat Rev 33(5):484–496
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Kruse, A.L.D., Riener, M.O., Graetz, K.W. et al. Mucosal malignant melanomas in head and neck surgery: a retrospective study of six patients and review of the literature. Oral Maxillofac Surg 14, 143–147 (2010). https://doi.org/10.1007/s10006-010-0207-z
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DOI: https://doi.org/10.1007/s10006-010-0207-z