Zusammenfassung
Patienten, bei denen die Durchführung einer Elektrokonvulsionstherapie indiziert ist, leiden meistens an einer schweren therapieresistenten psychiatrischen Erkrankung. Jedoch sollte wie bei anderen Therapieformen eine detaillierte Nutzen-Risiko-Analyse individuell für jeden Patienten durchgeführt werden. Eine umfassende Aufklärung des Patienten, von dessen Angehörigen und des gesetzlichen Betreuers muss innerhalb juristischer Vorgaben erfolgen und das Verhältnis von Wirkung zur Nebenwirkungen berücksichtigen. Die Elektrokonvulsionstherapie gilt heutzutage als sicheres Verfahren. Dennoch können, wie auch bei jedem anderen Therapieverfahren, Nebenwirkungen auftreten. Im vorliegenden Kapitel wird über mögliche akute und persistierende Nebenwirkungen und als Sonderstellung über die kognitiven Nebenwirkungen durch die Elektrokonvulsionstherapie berichtet.
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Literatur
Abrams R (1997) The mortality rate with ECT. Convuls Ther 13(3): 125–127
Agnew WF, McCreery DB (1987) Considerations for safety in the use of extracranial stimulation for motor evoked potentials. Neurosurgery 20: 143–147
Albin SM, Stevens SR, Rasmussen KG (2007). Blood pressure before and after electroconvulsive therapy in hypertensive and nonhypertensive patients. J ECT 23: 9–10
Altar CA, Laeng P et al (2004) Electroconvulsive seizures regulate gene expression of distinct neurotrophic signaling pathways. J Neurosci 24(11): 2667–2677
American Psychiatric Association Committee on Electroconvulsive Therapy (2001).Practice of Electroconvulsive Therapy: Recommendations for treatment, training, and privileging (A Task Force Report of the American Psychiatric Association). American Psychiatric Press, Washington DC
Angelucci F Aloe L et al (2002) Electroconvulsive stimuli alter the regional concentrations of nerve growth factor, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor in adult rat brain. J ECT 18(3): 138–143
Angst J, Angst K, Baruffol I et al (1992) ECT-induced and drug-induced hypomnia. Con vuls Ther 8: 179–185
Baghai T, Frey R et al (2004) Elektrokonvulsionstherapie: Klinische und wissenschaftliche Aspekte. Springer, Wien
Bailine SH, Rifkin A et al (2000) Comparison of bifrontal and bitemporal ECT for major depression. Am J Psychiatry 157(1): 121–123
Bakewell CJ, Russo J, Tanner C et al (2004) Comparison of clinical efficacy and side effects for bitemporal and bifrontal electrode placement in electroconvulsive therapy. J ECT 20: 145–153
Chamberlin E, Tsai GE (1998) A glutamatergic model of ECT-induced memory dysfunction. Harv Rev Psychiatry 5(6): 307–317
Coleman EA, Sackeim HA et al (1996) Subjective memory complaints before and after electroconvulsive therapy. Biol Psychiatry 39: 436–356
Damasio AR, Graff-Radford NR et al (1985) Amnesia following basal forebrain lesions. Arch Neurol 42(3): 263–271
DeBattista C, Mueller K (1995) Sumatriptan prophylaxis for postelectroconvulsive therapy headaches. Headache 35: 502–503
Devanand DP, Dwork AJ et al (1994) Does ECT alter brain structure? Am J Psychiatry 151: 957–970
Devanand DP, Fitzsimons L et al (1995) Subjective side effects during electroconvulsive therapy. Convuls Ther 11(4): 232–240
Dinwiddie SH, Huo D, Gottlieb O (2010) The course of myalgia and headache after electroconvulsive therapy. J ECT 26: 116–120
Drevets WC (2001) Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders. Curr Opin Neurobiol 11(2): 240–249
Dubovsky SL, Buzan R et al (2001) Nicardipine improves the antidepressant action of ECT but does not improve cognition. J ECT 1: 3–10
Ende G, Braus DF et al (2000) The hippocampus in patients treated with electroconvulsive therapy: a proton magnetic resonance spectroscopic imaging study. Arch Gen Psychiatry 57 (10): 937–943
Eriksson PS, Perfilieva E et al (1998) Neurogenesis in the adult human hippocampus. Nat Med 4(11): 1313–1317
Eschweiler GW, Vonthein R et al (2007) Clinical efficacy and cognitive side effects of bifrontal versus right unilateral electroconvulsive therapy (ECT): a short-term randomised controlled trial in pharmaco-resistant major depression. J Affect Disord 101(1–3): 149–157
Fantz et al (1998) Sumatriptan for post-ECT headache. J ECT 14: 272–274
Fernandes B, Gama CS et al (2009) Serum brain-derived neurotrophic factor (BDNF) is not associated with response to electroconvulsive therapy (ECT): a pilot study in drug resistant depressed patients. Neurosci Lett 453(3): 195–198
Folstein MF, Folstein SE et al (1975) „Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12(3): 189–198
Ghaziuddin N, King CA, Naylor MW et al (1996) Electroconvulsive treatment in adolescents with pharmacotherapy-refractory depression. J Child Adolesc Psychopharmacol 6: 259–271
Ghoname et al (1999) Use of percutaneous electrical nerve stimulation (PENS) for treating ECT-induced headaches. Headache 39: 502–505
Goldman-Rakic PS (1987) Circuitry of the frontal association cortex and its relevance to dementia. Arch Gerontol Geriatr 6(3): 299–309
Gomez J (1975) Subjective side-effects of ECT. Br J Psychiatry 127: 609–611
Grundmann U, Oest M (2007) Anästhesiologische Aspekte bei Elektrokrampftherapie. Anaesthesist 56(3): 202–204, 206–211
Hawken et al (2001) Successful use of propranolol in migraine associated with electroconvulsive therapy. Headache 41: 92–96
Herck E van, Sienaert P, Hagon A (2009) Electroconvulsive therapy for patients with intracranial aneurysms: a case study and literature review. Tijdschr Psychiatr 51: 4
Huber G (2005) Psychiatrie: Lehrbuch für Studium und Weiterbildung. Schattauer, Stuttgart
Ikeji OC, Ohaeri JU, Osahon RO, Agidee RO (1999) Naturalistic comparative study of outcome and cognitive effects of unmodified electro-convulsive therapy in schizophrenia, mania and severe depression in Nigeria. East Afr Med J 76: 644–650
James BO, Morakinyo O, Lawani AO et al (2010) Unmodified electroconvulsive therapy: the perspective of patients from a developing country. J ECT 26: 218–222
Kirov G, Ebmeier KP et al (2008) Quick recovery of orientation after magnetic seizure therapy for major depressive disorder. Br J Psychiatry 193(2): 152–155
Kopelman MD, Wilson BA et al (1989) The autobiographical memory interview: a new assessment of autobiographical and personal semantic memory in amnesic patients. J Clin Exp Neuropsychol 11(5): 724–744
Kramer BA, Kadar AG, Clark K (2008) Use of the Neuro-Wrap system for severe post-electroconvulsive therapy headaches. J ECT 24: 152–155
Kranaster L, Kammerer-Ciernioch J et al (2011) Clinically favourable effects of ketamine as an anaesthetic for electroconvulsive therapy: a retrospective study. Eur Arch Psychiatry Clin Neurosci 261(8): 575–582
Kranaster L, Janke C, Hoyer C et al (2012) Management of severe postictal agitation after electroconvulsive therapy with bispectrum electroencephalogram index monitoring: a case report. J ECT 28(2): 9–10
Kurthen M et al (2008) Status epilepticus im Erwachsenenalter. In: Diener HC, Putzki N Leitlinien für die Diagnostik und Therapie in der Neurologie, 4. überarb. Aufl. Thieme, Stuttgart
Lang UE, Bajbouj M et al (2006) Brain-derived neurotrophic factor serum concentrations in depressive patients during vagus nerve stimulation and repetitive transcranial magnetic stimulation. Psychopharmacology (Berl) 187(1): 56–59
Laursen H, Gjerris A et al (1991) Cerebral edema and vascular permeability to serum proteins following electroconvulsive shock in rats. Convuls Ther 7: 237–244
Leung et al (2003) Pretreatment with ibuprofen to prevent electroconvulsive therapy-induced headache. J Clin Psychiatry 64: 551–553
Li TC, Shiah IS, Sun CJ et al (2011) Mirtazapine relieves post-electroconvulsive therapy headaches and nausea: a case series and review of the literature.J ECT 27: 165–167
Ling H (1995) The ECT Handbook. The second report of the Royal College of Psychiatrists` Special committee on ECT (Council Report: CR39, Hrsg: Freemann CP). Dorset Press, Dorchester
Lisanby SH, Maddox JH et al (2000) The effects of electroconvulsive therapy on memory of autobiographical and public events. Arch Gen Psychiatry 57(6): 581–590
Logan CJ, Stewart JT (2012) Treatment of post-electroconvulsive therapy headache with topical methyl salicylate. J ECT 28: 17–18
Mackin RS, Ayalon L et al (2010) The sensitivity and specificity of cognitive screening instruments to detect cognitive impairment in older adults with severe psychiatric illness. J Geriatr Psychiatry Neurol 23(2): 94–99
Markowitz et al (2001) Intranasal sumatriptan in post-ECT headache: results of an open-label trial. J ECT 17: 280–283
McCall WV, Reid S et al (1994) Electrocardiographic and cardiovascular effects of subconvulsive stimulation during titrated right unilateral ECT. Convuls Ther 10(1): 25–33
McCall WV, Reboussin DM et al (2000) Titrated moderately suprathreshold vs fixed high-dose right unilateral electroconvulsive therapy: acute antidepressant and cognitive effects. Arch Gen Psychiatry 57: 438–444
McNally KA, Blumenfeld H (2004) Focal network involvement in generalized seizures: new insights from electroconvulsive therapy. Epilepsy Behav 5(1): 3–12
Mousavi SG, Mohsen G, Reza MM et al (2012) Efficacy of memoral herbal on prevention of electroconvulsive therapy-induced memory impairment in mood disorder patients (Isfahan - Iran 2011). Int J Prev Med 3(7): 499–503
Moscrip TD, Terrace HS et al (2004) A primate model of anterograde and retrograde amnesia produced by convulsive treatment. J ECT 20(1): 26–36
Mueller PS, Albin SM et al (2009) Safety of electroconvulsive therapy in patients with unrepaired abdominal aortic aneurysm: report of 8 patients. J ECT 25: 165–169
Oms et al (1998) Sumatriptan was effective in electroconvulsive therapy (ECT) headache. Anesthesiology 89: 1291–1292
Patkar AA, Hill KP et al (2000) ECT in the presence of brain tumor and increased intracranial pressure: evaluation and reduction of risk. J ECT 16: 189–197
Payne NA, Prudic J (2009) Electroconvulsive therapy part I: A perspective on the evolution and current practice of ECT. J Psychiatr Pract 15(5): 346–368
Pigot M, Andrade C, Loo C (2008) Pharmacological attenuation of electroconvulsive therapy-induced cognitive deficits: theoretical background and clinical findings. J ECT 24(1): 57–67
Prakash J, Kotwal A, Prabhu H (2006) Therapeutic and prophylactic utility of the memory-enhancing drug donepezil hydrochloride on cognition of patients undergoing electroconvulsive therapy: a randomized controlled trial. J ECT 22(3): 163–168
Prapotnik M, Pycha R et al (2006) Adverse cognitive effects and ECT. Wien Med Wochenschr 156(7–8): 200–208
Prudic J, Fitzsimons L et al (1999) Naloxone in the prevention of the adverse cognitive effects of ECT: a within-subject, placebo controlled study. Neuropsychopharmacology 21(2): 285–293
Puri et al (1998) Does electroconvulsive therapy lead to changes in cerebral structure? Br J Psychiatry 173: 267–272
Rehor G, Conca A, Schlotter W et al (2009) Rückfallraten innerhalb von 6 Monaten nach erfolgreicher EKT. Eine naturalistische prospektive Fremd- und Selbstbeurteilungsanalyse. Neuropsychiatrie 23(3): 157–163
Ressler KJ, Mayberg HS (2007) Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic. Nat Neurosci 10(9): 1116–1124
Ribot T (Hrsg) (1885) Sur les diverses formes du caractère. In: Revue philosophique, Les maladies de la personnalité. Alcan, Paris
Rose D, Fleischmann P et al (2003) Patients’ perspectives on electroconvulsive therapy: systematic review. BMJ 326(7403): 1363
Rovers JM, Roks G (2012) Electroconvulsive therapy-induced migraine successfully treated with valproic acid. J ECT 28: 64–65
Sackeim HA (2000) Memory and ECT: from polarization to reconciliation. J ECT 16(2): 87–96
Sackeim HA, Ross FR, Hopkins N et al (1987) Subjective side effects acutely following ECT: Associations with treatment modality and clinical response. Convuls Ther 3:100–110
Sackeim HA, Prudic J et al (1993) Effects of stimulus intensity and electrode placement on the efficacy and cognitive effects of electroconvulsive therapy. N Engl J Med 328(12): 839–846
Sackeim HA, Devanand DP et al (Hrsg) (1995) Electroconvulsive therapy. Psychopharmacology: the fourth generation of progress. Raven Press, New York NY
Sackeim HA, Prudic J et al (2007) The cognitive effects of electroconvulsive therapy in community settings. Neuropsychopharmacology 32(1): 244–254
Sackeim HA, Prudic J et al (2008) Effects of pulse width and electrode placement on the efficacy and cognitive effects of electroconvulsive therapy. Brain Stimul 1(2): 71–83
Saricicek V, Sahin L, Bulbul F et al (2013) Does Rocuronium-Sugammadex reduce myalgia and headache after electroconvulsive therapy in patients with major depression? J ECT Jun 27 (im Druck)
Semkovska M, McLoughlin D (2010) Objective cognitive performance associated with electroconvulsive therapy for depression: A systematic review and meta-analysis. Biol Psychiatry 68: 568–577
Shimamura A, Gazzaniga M (Hrsg) (1994) Memory and frontal lobe function. The cognitive neuroscience. MIT Press, Cambridge MA
Sienaert P, De Becker T et al (2005) Patient satisfaction after electroconvulsive therapy. J ECT 21(4): 227–231
Sobin C, Sackeim HA et al (1995) Predictors of retrograde amnesia following ECT. Am J Psychiatry 152(7): 995–1001
Squire LR, Slater PC et al (1981) Retrograde amnesia and bilateral electroconvulsive therapy. Long-term follow-up. Arch Gen Psychiatry 38(1): 89–95
Squire LR, Alvarez P (1995) Retrograde amnesia and consolidation: a neurobiological perspective. Curr Opin Neurobiol 5: 169–177
Stead M, Josephs KA (2005) Successful treatment of status migrainosus after electroconvulsive therapy with dihydroergotamine. Headache 45: 378–380
Steif BL, Sackeim HA et al (1986) Effects of depression and ECT on anterograde memory. Biol Psychiatry 21(10): 921–930
Weiner RD, Rogers HJ et al (1986) Effects of stimulus parameters on cognitive side effects. Ann N Y Acad Sci 462: 315–325
Weiner SJ, Ward TN, Ravaris CL (1994) Headache and electroconvulsive therapy. Headache 34: 155–159
Weinstein RM (1993) Migraine occurring as sequela of electroconvulsive therapy. Headache 33: 45
Zachrisson OC, Balldin J et al (2000) No evident neuronal damage after electroconvulsive therapy. Psychiatry Res 96(2): 157–165
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Kayser, S. et al. (2013). Sicherheits- und Nebenwirkungsprofil der EKT. In: Grözinger, M., Conca, A., Nickl-Jockschat, T., Di Pauli, J. (eds) Elektrokonvulsionstherapie kompakt. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-25629-5_7
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