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Zentrale Schwindelsyndrome

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Vertigo – Leitsymptom Schwindel

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Zusammenfassung

Zentrale vestibuläre Schwindelformen entstehen durch Läsionen entlang der vestibulären Verbindungen im Hirnstamm, von den Vestibulariskernen in der Medulla oblongata zu den okulomotorischen Kernen und Integrationszentren im rostralen Mittelhirn sowie zum Vestibulozerebellum, Thalamus und vestibulären Kortex im temporoparietalen Großhirn (Brandt u. Dieterich 1995; Baier et al. 2008, 2009.

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Literatur

Literatur zu Kap. 3.1

  • Averbuch-Heller L, Tusa RJ, Fuhry L, Rottach KG, Ganser GL, Heide W, Büttner U, Leigh RJ (1997) A double-blind controlled study of gabapentin and baclofen as treatment for acquired nystagmus. Ann Neurol 41:818–825

    Article  CAS  PubMed  Google Scholar 

  • Baier B, Bense S, Dieterich M (2008) Are signs of ocular tilt reaction in patients with cerebellar lesions mediated by the dentate nucleus? Brain 131:1445–1454

    Article  CAS  PubMed  Google Scholar 

  • Baier B, Dieterich M (2009) Ocular tilt reaction – a clinical sign of cerebellar infarctions? Neurology 72:572–3

    Article  PubMed  Google Scholar 

  • Baier B, Janzen J, Fechir M, Müller N, Dieterich M (2012a) Pusher syndrome – its anatomical correlate. J Neurol 259:277–83

    Article  Google Scholar 

  • Baier B, Suchan J, Karnath HO, Dieterich M (2012b) Neuronal correlate of verticality perception – a voxelwise lesion study. Neurology 78:728–35

    Article  Google Scholar 

  • Baloh RW, Jacobson K, Honrubia V (1993) Horizontal semicircular canal variant of benign positional vertigo. Neurology 43:2542–2549

    Article  CAS  PubMed  Google Scholar 

  • Baloh RW, Spooner JW (1981) Downbeat nystagmus. A type of central vestibular nystagmus. Neurology 31:304–310

    Article  CAS  PubMed  Google Scholar 

  • Baloh RW, Yee RD (1989) Spontaneous vertical nystagmus. Rev Neurol 145:527–532

    CAS  PubMed  Google Scholar 

  • Barra J, Marquer A, Joassin R et al. (2010) Humans use internal models to construct and update sense of verticality. Brain 133;3552–3563

    Article  PubMed  Google Scholar 

  • Bense S, Best C, Buchholz HG, Wiener V, Schreckenberger M, Bartenstein P, Dieterich M (2006) 18F-fluorodeoxyglucose hypometabolism in cerebellar tonsil and flocculus in downbeat-nystagmus. Neuroreport 17:599–603

    Article  PubMed  Google Scholar 

  • Brandt T, Dieterich M (1994) Vestibular syndromes in the roll plane: Topographic diagnosis from brainstem to cortex. Ann Neurol 36:337–347

    Article  CAS  PubMed  Google Scholar 

  • Brandt T, Dieterich M (1995) Central vestibular syndromes in roll, pitch, and yaw planes. Topographic diagnosis of brainstem disorders. Neuro-ophthalmol 15:291–303

    Article  Google Scholar 

  • Brandt T, Dieterich M, Danek A (1994) Vestibular cortex lesions affect the perception of verticality. Ann Neurol 35:528–534

    Article  Google Scholar 

  • Brandt T, Dieterich M, Büchele W (1986) Postural abnormalities in central vestibular brain stem lesions. In: Bles W, Brandt T (eds) Disorders of Posture and Gait. Elsevier, Amsterdam New York Oxford; pp 141–56

    Google Scholar 

  • Büttner U, Helmchen C, Büttner-Ennever JA (1995) The localizing value of nystagmus in brainstem disorders. Neuroophthalmology 15:283–290

    Article  Google Scholar 

  • Büttner U, Hoshi M, Kempermann U, Eggert T, Glasauer S (2002) Neural integrator-saccade generator mismatch: A possible cause of downbeat nystagmus? J Vest Res 11:294

    Google Scholar 

  • Büttner-Ennever JA, Horn AKE, Schmidtke K (1989) Cell groups of the medial longitudinal fasciculus and paramedian tracts. Rev Neurol 145:533–539

    PubMed  Google Scholar 

  • Büttner-Ennever JA (2008) Mapping the oculomotor system. Prog Brain Res 171:3–11

    Article  PubMed  Google Scholar 

  • Cnyrim CD, Newman-Toker D, Karch C, Brandt T, Strupp M (2008) Beside differentiation of vestibular neuritis from central »vestibular pseudoneuritis«. J Neurol Neurosurg Psychiatry 79(4):458-460

    Article  CAS  PubMed  Google Scholar 

  • Cnyrim CD, Rettinger N, Mansmann U, Brandt T, Strupp M (2007) Central compensation of deviated subjective visual vertical in Wallenberg’s syndrome. J Neurol Neurosurg Psychiatry 78:527–528

    Article  PubMed  Google Scholar 

  • Cox TA, Corbett JJ, Thompson S et al. (1981) Upbeat nystagmus changing to downbeat nystagmus with convergence. Neurology 31:891–892

    Article  CAS  PubMed  Google Scholar 

  • De Jong JMBV, Cohen B, Matsuo V, Uemura T (1980) Midsagittal pontomedullary brainstem section: effects on ocular adduction and nystagmus. Exp Neurol 68:420–442

    Article  PubMed  Google Scholar 

  • Dichgans M, Dieterich M (1995) Third nerve palsy with contralateral ocular torsion and binocular tilt of visual vertical, indicating a midbrain lesion. Neuro-ophthalmol 15:315–320

    Article  Google Scholar 

  • Dieterich M, Brandt T (1992) Wallenberg’s syndrome: Lateropulsion, cyclorotation, and subjective visual vertical in thirty-six patients. Ann Neurol 31:399–408

    Article  CAS  PubMed  Google Scholar 

  • Dieterich M, Brandt T (1993a) Ocular torsion and tilt of subjective visual vertical are sensitive brainstem signs. Ann Neurol 33:292–299

    Article  CAS  Google Scholar 

  • Dieterich M, Brandt T (1993b) Thalamic infarctions: Differential effects on vestibular function in roll plane (35 patients). Neurology 43:1732–1740

    Article  CAS  Google Scholar 

  • Dieterich M, Brandt T (1993c) Ocular torsion and perceived vertical in oculomotor, trochlear and abducens nerve palsies. Brain 116:1095–1104

    Article  Google Scholar 

  • Dieterich M, Grünbauer M, Brandt T (1998) Direction-specific impairment of motion perception and spatial orientation in downbeat and upbeat nystagmus in humans. Neurosci Lett 245:29–32

    Article  CAS  PubMed  Google Scholar 

  • Dieterich M, Straube A, Brandt T, Paulus W, Büttner U (1991) The effects of baclofen and cholinergic drugs on upbeat and downbeat nystagmus. J Neurol, Neurosurg Psychiatry 54:627–632

    Article  CAS  Google Scholar 

  • Etzion Y, Grossman Y (2001) Highly 4-aminopyridine sensitive delayed rectifier current modulates the excitability of guinea pig cerebellar Purkinje cells. Exp Brain Res 139:419–425

    Article  CAS  PubMed  Google Scholar 

  • Glasauer S, Kalla R, Buttner U, Strupp M, Brandt T (2005a) 4-aminopyridine restores visual ocular motor function in upbeat nystagmus. J Neurol Neurosurg Psychiatry 76:451–453

    Article  CAS  Google Scholar 

  • Glasauer S, Strupp M, Kalla R, Büttner U, Brandt T (2005b) Effect of 4-aminopyridine on upbeat and downbeat nystagmus elucidates the mechanism of downbeat nystagmus. Ann NY Acad Sci 1039:528–531

    Article  CAS  Google Scholar 

  • Helmchen C, Rambold H, Fuhry L, Büttner U (1998) Deficits in vertical and torsional eye movements after uni- and bilateral muscimol inactivation of the interstitial nucleus of Cajal of the alert monkey. Exp Brain Res 119:436–452

    Article  CAS  PubMed  Google Scholar 

  • Hopf HC (1987) Vertigo and masseter paresis. A new local brain-stem syndrome probably of vascular origin. J Neurol 235:42–5

    Article  CAS  PubMed  Google Scholar 

  • Hüfner K, Stephan T, Kalla R, Deutschländer A, Wagner J, Holtmannspötter M, Schulte-Altedorneburg G, Strupp M, Brandt T, Glasauer S (2007) Structural and functional MRIs disclose cerebellar pathologies in idiopathic downbeat nystagmus. Neurology 69:1128–1135

    Article  PubMed  Google Scholar 

  • Janssen JC, Larner AJ, Morris H, Bronstein AM, Farmer SF (1998) Upbeat nystagmus: clinicoanatomical correlation. J Neurol, Neurosurg Psychiatry 65:380–381

    Article  CAS  Google Scholar 

  • Johannsen L, Fruhmann, Berger M, Karnath HO (2006) Subjective visual vertical (SVV) determined in a representative sample of 15 patients with pusher syndrome. J Neurol 253:1367–9

    Article  PubMed  Google Scholar 

  • Kalla R, Deutschländer A, Hüfner K et al. (2006) Detection of floccular hypometabolism in downbeat nystagmus by fMRI. Neurology 66:281–3

    Article  CAS  PubMed  Google Scholar 

  • Kalla R, Glasauer S, Buttner U, Brandt T, Strupp M (2007) 4-aminopyridine restores vertical and horizontal neural integrator function in downbeat nystagmus. Brain 130:2441–2450

    Article  PubMed  Google Scholar 

  • Kalla R, Glasauer S, Schautzer F, Lehnen N, Büttner U, Strupp M, Brandt T (2004) 4-Aminopyridine improved downbeat- nystagmus, smooth pursuit, and VOR-gain. Neurology 62:1228–1229

    Article  CAS  PubMed  Google Scholar 

  • Kattah JC, Talkad AV, Wang DZ et al. (2009) HINTS to diagnose stroke in acute vestibular syndrome. Three-step bedside oculomotor examination more sensitive than early MRI diffusion-weighted imaging. Stroke 40:3504–3510

    Article  PubMed  Google Scholar 

  • Kim HA, Lee H (2010) Isolated vestibular nucleus infarction mimicking acute peripheral vestibulopathy. Stroke 41:558–560

    Google Scholar 

  • Kirchner H, Kremmyda O, Hüfner K, Stephan T, Zingler V, Brandt T, Jahn K, Strupp M (2011) Clinical, electrophysiological, and MRI findings in patients with cerebellar ataxia and a bilaterally pathological head-impulse test. Ann NY Acad Sci 1233:127–138

    Article  PubMed  Google Scholar 

  • Lee CC, Suy C, Ho HC, Hung SK, Lee MS, Chou P, Huang YS (2011) Risk of stroke in patients hospitalized for isolated vertigo. A four year follow-up study. Stroke 42:48–52

    Article  PubMed  Google Scholar 

  • Leigh RJ, Zee DS (2006) The Neurology of Eye Movements, 4th ed. Oxford University Press, New York Oxford

    Google Scholar 

  • Marti S, Straumann D, Glasauer S (2005) The origin of downbeat- nystagmus: An asymmetry in the distribution of ondirections of vertical gaze-velocity Purkinje-cells. Ann NY Acad Sci 1039:548–553

    Article  PubMed  Google Scholar 

  • Nakada T, Remler MP (1981) Primary position upbeat nystagmus. J Clin Neuroophthlmol 1:185–189

    CAS  Google Scholar 

  • Newman-Toker DE, Kattah JC, Alvernia JE, Wang DZ (2008) Normal head impulse test differentiates acute cerebellar strokes from vestibular neuritis. Neurology 70:2378–2385

    Article  PubMed  Google Scholar 

  • Pierrot-Deseilligny C, Milea D (2005) Vertical nystagmus: clinical facts and hypotheses. Brain 128:1237–46

    Article  CAS  PubMed  Google Scholar 

  • Pierrot-Deseilligny C, Milea D, Sirmai J, Papeix C, Rivaud-Pechoux S (2005) Upbeat nystamus due to a small pontine lesion: evidence for the existence of a crossing ventral tegmental tract. Eur Neurol 54:186–90

    Article  CAS  PubMed  Google Scholar 

  • Pierrot-Deseilligny C, Richeh W, Bolgert F (2007) Upbeat nystagmus due to a caudal medullary lesion influenced by gravity. J Neurol 254:120–121

    Article  PubMed  Google Scholar 

  • Ranalli RJ, Sharpe JA (1988) Upbeat nystagmus and the ventral tegmental pathway of the upward vestibulo-ocular reflex. Neurology 38:1329–1330

    Article  CAS  PubMed  Google Scholar 

  • Sander T, Sprenger A, Mart S, Naumann T, Straumann D, Helmchen C (2011) Effect of 4-aminopyridine on gravity dependence and neural integrator function in patients with idiopathic downbeat nystagmus. J Neurol 258:618–22

    Article  CAS  PubMed  Google Scholar 

  • Spiegel R, Kalla R, Rettinger N, Schneider E, Straumann D et al. (2010) Head position during resting modifies spontaneous daytime decrease of downbeat nystagmus. Neurology 75:1928–1932

    Article  CAS  PubMed  Google Scholar 

  • Spiegel R, Rettinger N, Kalla R, Lehnen N et al. (2009) The intensity of downbeat nystagmus during daytime. Ann NY Acad Sci 1164:293–299

    Article  PubMed  Google Scholar 

  • Strack M, Albrecht H, Pöllmann W, Straube A, Dieterich M(2010) Acquired pendular nystagmus in MS: an examinerblind cross-over study of memantine and gabapentin. J Neurol 257:322–227

    Article  Google Scholar 

  • Strupp M, Kalla R, Dichgans M, Freilinger T, Glasauer S, Brandt T (2004) Treatment of episodic ataxia type 2 with the potassium channel blocker 4-aminopyridine. Neurology 62:1623–1625

    Article  CAS  PubMed  Google Scholar 

  • Strupp M, Schüler O, Krafczyk S, Jahn K, Schautzer F, Büttner U, Brandt T (2003) Treatment of downbeat-nystagmus with 3,4-diaminopyridin - placebo-controlled study. Neurology 61:165–170

    Article  CAS  PubMed  Google Scholar 

  • Strupp M, Thurtell MJ, Shaikh AS, Brandt T, Zee DS, Leigh RJ (2011) Pharmacotherapy of vestibular and ocular motor disorders, including nystagmus. J Neurol 258:1207–1222

    Article  CAS  PubMed  Google Scholar 

  • Szmulewicz DJ, Waterson JA, Halamgyi GM, Mossmann S, Chancellor AM, McLean CA, Storey E (2011) Sensory neuropathy as part of the cerebellar ataxia neuropathy vestibular areflexia syndrome. Neurology 76:1903–1910

    Article  CAS  PubMed  Google Scholar 

  • Thurtell MJ, Joshi AC, Leone AC, Tomsak RL, Kosmorsky GS, Stahl JS, Leigh RJ (2010) Cross over-trail of gabapentin and memantine as treatment for aquired nystagmus. Ann Neurol 67:676–680

    CAS  PubMed  Google Scholar 

  • Tilikete C, Milea D, Pierrot-Deseilligny C (2008) Upbeat nystagmus from a demyelinating lesion in the caudal pons. J Neuro-ophthalmol 28:202–6

    Article  Google Scholar 

  • Tsunemi T, Ishikawa K, Tsukui K, Sumi T, Kitamura K, Mizusawa H (2010) The effect of 3,4-diaminopyridine on the patients with hereditary pure cerebellar ataxia. J Neurol Sci 292:81–84

    Article  CAS  PubMed  Google Scholar 

  • Wagner JN, Glaser M, Brandt T, Strupp M (2008) Downbeat nystagmus: aetiology and comorbidity in 117 patients. J Neurol Neurosurg Psychiatry 79:672–677

    Article  CAS  PubMed  Google Scholar 

  • Zee DS, Yamazaki A, Butler PH, Gücer F (1981) Effects of ablation of flocculus and paraflocculus on eye movements in primate. J Neurophysiol 46:878–899

    CAS  PubMed  Google Scholar 

  • Zwergal A, Büttner-Ennever J, Brandt T, Strupp M (2008) An ipsilateral vestibulothalamic tract adjacent to the medial lemniscus in humans. Brain 131:2928–2935

    Article  PubMed  Google Scholar 

Literatur zu Kap. 3.2

  • Baier B, Winkenwerder E, Dieterich M (2009a) Vestibular migraine: Effects of prophylactic therapy. J Neurol 256:426–442

    Google Scholar 

  • Baier B, Stieber N, Dieterich M (2009b) Vestibular-evoked myogenic potentials in »vestibular migraine«. J Neurol 256:1447–1454

    Article  Google Scholar 

  • Best C, Eckhardt-Henn A, Tschan R, Bense S, Dieterich M (2009) Psychiatric morbidity and comorbidity in different vestibularvertigo syndomes: Results of a prospective longitudinal study over one year. J Neurol 256:58–65

    Article  PubMed  Google Scholar 

  • Bickerstaff ER (1962) The basilar artery and the migraine – epilepsy syndrome. Proc R Soc Med 55:167–169

    CAS  PubMed  Google Scholar 

  • Bikhazi P, Jackson C, Ruckenstein MJ (1997) Efficacy of antimigrainous therapy in the treatment of migraine-associated dizziness. Am J Otol 18:350--354

    CAS  PubMed  Google Scholar 

  • Cutrer FM, Baloh RW (1992) Migraine-associated dizziness. Headache 32:300–304

    Article  CAS  PubMed  Google Scholar 

  • De Fusco M, Marconi R, Silvestri L et al. (2003) Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2. Nat Genet 33:192–196

    Article  PubMed  Google Scholar 

  • Dichgans M, Freilinger T, Eckstein G et al. (2005) Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine. Lancet 366:371–377

    Article  CAS  PubMed  Google Scholar 

  • Dieterich M, Brandt T (1999) Episodic vertigo related to migraine (90 cases): vestibular migraine? J Neurol 246:883–892

    Article  CAS  PubMed  Google Scholar 

  • Eckhardt-Henn A, Best C, Bense S, Breuer P, Diener G, Tschan R, Dieterich M (2008) Psychiatric comorbidity in different organic vertigo syndromes. J Neurol 255:420–8

    Article  PubMed  Google Scholar 

  • Furman JM, Marcus DA, Balaban CD (2003) Migrainous vertigo: development of a pathogenetic model and structured diagnostic interview. Curr Opin Neurol 16:5–13

    Article  PubMed  Google Scholar 

  • Goadsby PJ (2000) The pharmacology of headache. Prog Neurobiol 62:509–525

    Article  CAS  PubMed  Google Scholar 

  • Griggs RC, Nutt JG (1995) Episodic ataxias as channalopathies. Ann Neurol 37:285–287

    Article  CAS  PubMed  Google Scholar 

  • International Headache Society (2004) International Classification of Headache Disorders, 2nd ed. Cephalalgia 24: 9–160

    Article  Google Scholar 

  • Ishiyama A, Jacobson KM, Baloh RW (2000) Migraine and benign positional vertigo. Otol Rhinol Laryngol 109:377–380

    CAS  Google Scholar 

  • Lee H, Lopez I, Ishiyama A, Baloh RW (2000) Can migraine damage the inner ear? Arch Neurol 57:1631

    Article  CAS  PubMed  Google Scholar 

  • Lempert T, Neuhauser H (2009) Epidemiology of vertigo, migraine and vestibular migraine. J Neurol 256: 333–338

    Article  PubMed  Google Scholar 

  • Lempert T, Neuhauser H, Daroff RB (2009) Vertigo as a symptom of migraine. Ann NY Acad Sci 1164:242–251

    Article  PubMed  Google Scholar 

  • Neuhauser H, Leopold M, von Brevern M, Arnold G, Lempert T (2001) The interrelations of migraine, vertigo and migrainous vertigo. Neurology 56:436–441

    Article  CAS  PubMed  Google Scholar 

  • Neuhauser H, Radtke A, von Brevern M, Lempert T (2003) Zolmitriptan for treatment of migrainous vertigo: a pilot randomised placebo-controlled trial. Neurology 60:882–883

    Article  CAS  PubMed  Google Scholar 

  • Neuhauser H, Radtke A, von Brevern M, Feldmann M, Lezius F, Ziese T, Lempert T (2006) Migrainous vertigo: prevalence and impact on quality of life. Neurology 67:1028–1033

    Article  CAS  PubMed  Google Scholar 

  • Ophoff RA, Terwindt GM, Vergouwe MN, van Eijk R, Oefner PJ, Hoffman SM et al. (1996) Familian hemiplegic migraine and episodic ataxaia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4. Cell 87:543–552

    Article  CAS  PubMed  Google Scholar 

  • Radtke A, Lempert T, Gresty MA, Brookes GB, Bronstein AM, Neuhauser H (2002) Migraine and Meniere’s disease. Is there a link? Neurology 59:1700–1704

    Article  CAS  Google Scholar 

  • Radtke A, Neuhauser H, von Brevern M et al. (2011) Vestibular migraine – validity of clinical diagnostic criteria. Cephalalgia 31:906–913

    Article  PubMed  Google Scholar 

  • Rassekh CH, Harker LA (1992) The prevalence of migraine in Meniere’s disease. Laryngoscope 102:135–138

    Article  CAS  PubMed  Google Scholar 

  • Richter F, Bauer R, Lehmenkühler A, Schaible HG (2008) Spreading depression in the brainstem of the adult rat: electrophysiological parameters and influences on regional brainstem blood flow. J Cereb Blood Flow Metab 28:984–994

    Article  PubMed  Google Scholar 

  • Strupp M, Kalla R, Claassen J, Adrion C, Mansmann U, Klopstock T, Freilinger T, Neugebauer H, Spiegel R, Dichgans M, Lehmann-Horn F, Jurkat-Rott K, Brandt T, Jen JC, Jahn K (2011) A randomized trial of 4-aminopyridine in EA2 and related familial episodic ataxias. Neurology 77:269–275

    Article  CAS  PubMed  Google Scholar 

  • Strupp M, Versino M, Brandt T (2010) Vestibular migraine. Handb Clin Neurol 97:755–771

    Article  PubMed  Google Scholar 

  • Von Brevern M, Zeise D, Neuhauser H, Clarke AH, Lempert T (2005) Acute migrainous vertigo: clinical and oculographic findings. Brain 128:365–374

    Article  Google Scholar 

  • Weiller C, May A, Limmroth V, Jüpter M, Kaube H, van Schayck R, Coenen HH, Diener HC (1995) Brain stem activation in spontaneous human migraine attacks. Nat Med 1:658–660

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Inst. Klinische Neurowissenschaften und Deutsches Schwindelzentrum Campus Großhadern, Klinikum der Universität München, München

    Prof. Dr. Thomas Brandt

  2. Klinik und Poliklinik für Neurologie und Deutsches Schwindelzentrum Campus Großhadern, Klinikum der Universität München, München

    Prof. Dr. Marianne Dieterich & Prof. Dr. Michael Strupp

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  2. Prof. Dr. Marianne Dieterich
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  3. Prof. Dr. Michael Strupp
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Brandt, T., Dieterich, M., Strupp, M. (2013). Zentrale Schwindelsyndrome. In: Vertigo – Leitsymptom Schwindel. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-24963-1_3

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