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Nanocarriers and Cancer Therapy: Approaches to Topical and Transdermal Delivery

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Nanocosmetics and Nanomedicines

Abstract

The main goals of nanotechnology in cancer are to develop safer and more effective diagnostics and therapeutics. Nanotechnology can bring advantages to drug delivery, overcoming the limitations of conventional formulations. Drugs encapsulated in targeted nanocarriers are promising for the improvement of efficacy and safety of not only currently available drugs, but also certain chemical or biological compounds that were not previously used due to toxic effects or because they were not able to be administered. Drug delivery across the skin is an extremely attractive route due to the possibility of targeting skin diseases (topical), for achieving systemic effects (transdermal administration), providing patient convenience, and avoiding first-pass hepatic metabolism. However, this route still remains a challenge due the highly organised stratum corneum structure. Several strategies have been studied to optimize topical and transdermal drug delivery, including physical techniques, such as eletroporation and iontophoresis, and nanotechnology-based drug delivery systems. This work discusses nanotechnology evolution and the use of several nanotechnology strategies to increase skin penetration and permeation in the improvement of cancer treatment.

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Authors and Affiliations

  1. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Brazil

    Juliana M. Marchetti, Marina C. de Souza & Samantha S. Marotta-Oliveira

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  1. Juliana M. Marchetti
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  2. Marina C. de Souza
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  3. Samantha S. Marotta-Oliveira
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Editors and Affiliations

  1. Dept. de Produção e Controle de Medicame, Faculdade de Farmácia, Federal University of Rio Grande do Sul, Av. Ipiranga 2752, 90610-000, Porto Alegre, Brazil

    Ruy Beck

  2. Faculty of Pharmacy, Dept. de Produção e Controle de Medicame, Federal University of Rio Grande do Sul, Av. Ipiranga 2752, 90610-000, Porto Alegre, Brazil

    Silvia Guterres

  3. Institut of Chemistry, Departamento de Química Orgânica, Federal University of Rio Grande do Sul, Av. Bento Gonçalves 9500, 91501-970, Porto Alegre, Brazil

    Adriana Pohlmann

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Marchetti, J.M., de Souza, M.C., Marotta-Oliveira, S.S. (2011). Nanocarriers and Cancer Therapy: Approaches to Topical and Transdermal Delivery. In: Beck, R., Guterres, S., Pohlmann, A. (eds) Nanocosmetics and Nanomedicines. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19792-5_14

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