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Biogenic Amines in the Skin

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Sensing the Environment: Regulation of Local and Global Homeostasis by the Skin's Neuroendocrine System

Part of the book series: Advances in Anatomy, Embryology and Cell Biology ((ADVSANAT,volume 212))

Abstract

It has been documented that skin resident cells can produce and further metabolize catecholamines, serotonin, and histamine (Fitzpatrick et al. 1993; Gillbro et al. 2004; Schallreuter et al. 1995; Slominski et al. 2005c). These biogenic amines not only regulate phenotype of skin cells cultured in vitro but also can affect skin functions and may have systemic effects (Schallreuter et al. 1997; Slominski and Wortsman 2000; Slominski et al. 2005c). The functional activity of biogenic amines in the skin is mediated through the interactions with specific cell surface receptors (Gillbro et al. 2004; Nordlind et al. 2008; Slominski et al. 2003d); however, non-receptor effects are also considered.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, and Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA

    Andrzej T. Slominski

  2. Department of Histology, Medical University of Gdansk, Gdansk, Poland

    Michal A. Zmijewski

  3. Department of Pathology and Laboratory Medicine, University of Tennessee Health Sciences Center, Memphis, TN, USA

    Cezary Skobowiat & Blazej Zbytek

  4. University of Tennessee Health Science Center, Memphis, TN, USA

    Radomir M. Slominski

  5. Jagiellonian University Medical College, Krakow, Poland

    Radomir M. Slominski

  6. Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN, USA

    Jeffery D. Steketee

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  1. Andrzej T. Slominski
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  3. Cezary Skobowiat
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Slominski, A.T., Zmijewski, M.A., Skobowiat, C., Zbytek, B., Slominski, R.M., Steketee, J.D. (2012). Biogenic Amines in the Skin. In: Sensing the Environment: Regulation of Local and Global Homeostasis by the Skin's Neuroendocrine System. Advances in Anatomy, Embryology and Cell Biology, vol 212. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19683-6_2

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