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Altered catecholamine synthesis and degradation in the epidermis of patients with atopic eczema

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Abstract Patients with atopic eczema have significantly higher norepinephrine levels in plasma than healthy controls. In addition, significantly higher levels of the essential cofactor (6R)-l-erythro-5,6,7,8-tetrahydrobiopterin (6BH4) were found in this patient group. Cell extracts from epidermal suction blister roofs revealed only half the normal activity of phenylethanolamine-N-methyl transferase (PNMT) together with a threefold induction of the norepinephrine-degrading enzyme monoamine oxidase A (MAO-A). Taken together, these results support earlier observations of a defective catecholamine/adrenoceptor signal in patients with atopic eczema.

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Authors and Affiliations

  1. Clinical and Experimental Dermatology Department of Biomedical Sciences, University of Bradford, Bradford BD7 1DP, UK Fax +44 1274 385290; e-mail: K.Schallreuter@Bradford.ac.uk, , , , , , GB

    K. U. Schallreuter & Wayne D. Beazley

  2. Department of Dermatology, Mayo Clinic, Rochester, MN, USA, , , , , , US

    Mark R. Pittelkow & Norma N. Swanson

  3. Department of Dermatology, University of Hamburg, Hamburg, Germany, , , , , , DE

    Christa Körner, Christine Ehrke & Gerd Büttner

Authors
  1. K. U. Schallreuter
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  2. Mark R. Pittelkow
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  3. Norma N. Swanson
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  4. Wayne D. Beazley
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  5. Christa Körner
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  6. Christine Ehrke
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  7. Gerd Büttner
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Received: 9 December 1996

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Schallreuter, K., Pittelkow, M., Swanson, N. et al. Altered catecholamine synthesis and degradation in the epidermis of patients with atopic eczema. Arch Dermatol Res 289, 663–666 (1997). https://doi.org/10.1007/s004030050258

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  • DOI: https://doi.org/10.1007/s004030050258

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