Abstract
Patients receiving heparin therapy can develop heparin-induced thrombocytopenia (HIT). In HIT type I, a nonimmunological interaction of heparin and thrombocytes causes a reduction in platelet count with minor clinical implication. HIT type II, however, is considered to be a serious complication of heparin therapy. Antibodies against complexes of heparin and platelet factor 4 (PF-4) lead to an activation of thrombocytes and endothelial cells and an increase in thrombin production resulting in thrombocytopenia. In severe cases, life-threatening thromboembolic complications occur (review in [1]).
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Severin, T. et al. (2001). HIT Type II without Thrombocytopenia in a 15-Year-Old Boy with Protein S Deficiency and Recurrent Deep Vein Thrombosis. In: Scharrer, I., Schramm, W. (eds) 30th Hemophilia Symposium Hamburg 1999. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18240-2_14
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DOI: https://doi.org/10.1007/978-3-642-18240-2_14
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