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Nebenschilddrüsen

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Pathologie

Part of the book series: Pathologie ((PATHOL))

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Zusammenfassung

Dieses große Kapitel fasst die hyperplastischen und neoplastischen Erkrankungen der Nebenschilddrüse zusammen. Dabei wird detailliert in Bild und Text auf die morphologischen Erscheinungsformen der Tumoren eingegangen. Gleichzeitig werden die wichtigsten Informationen zu Epidemiologie, Genetik und Biologie zusammengestellt.

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Literatur

  1. Arnold A, Brown MF, Urena P, Gaz RD, Sarfati E, Drueke TB (1995) Monoclonality of parathyroid tumors in chronic renal failure and in primary parathyroid hyperplasia. J Clin Invest 95:2047–2053

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  2. Bondeson L, Sandelin K, Grimelius L (1993) Histopathological variables and DNA cytometry in parathyroid carcinoma. Am J Surg Pathol 17:820–829

    Article  CAS  PubMed  Google Scholar 

  3. Boyle NH, Ogg CS, Hartley RB, Owen WJ (1999) Parathyroid carcinoma secondary to prolonged hyperplasia in chronic renal failure and in coeliac disease. Eur J Surg Oncol 25:100–103

    CAS  PubMed  Google Scholar 

  4. Busaidy NL, Jimenez C, Habra MA, Schultz PN, El-Naggar AK, Clayman GL, Asper JA, Diaz EM Jr., Evans DB, Gagel RF, Garden A, Hoff AO, Lee JE, Morrison WH, Rosenthal DI, Sherman SI, Sturgis EM, Waguespack SG, Weber RS, Wirfel K, Vassilopoulou-Sellin R (2004) Parathyroid carcinoma: a 22-year experience. Head Neck 26:716726

    Article  Google Scholar 

  5. Carpten JD, Robbins CM, Villablanca A, Forsberg L, Presciuttini S, Bailey-Wilson J, Simonds WF et al (2002) HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome. Nat Genet 32:676–680

    Article  CAS  PubMed  Google Scholar 

  6. Cetani F, Ambrogini E, Viacava P, Pardi E, Fanelli G, Naccarato AG, Borsari S, Lemmi M, Berti P, Miccoli P, Pinchera A, Marcocci C (2007) Should parafibromin staining replace HRTP2 gene analysis as an additional tool for histologic diagnosis of parathyroid carcinoma? Eur J Endocrinol 156:547–554

    Article  CAS  PubMed  Google Scholar 

  7. Cetani F, Pardi E, Borsari S, Viacava P, Dipollina G, Cianferotti L, Ambrogini E, Gazzerro E, Colussi G, Berti P, Miccoli P, Pinchera A, Marcocci C (2004) Genetic analyses of the HRPT2 gene in primary hyperparathyroidism: germline and somatic mutations in familial and sporadic parathyroid tumors. J Clin Endocrinol Metab 89:5583–5591

    Article  CAS  PubMed  Google Scholar 

  8. Chan JKC (2007) The Parathytoid Glands. In: Fletcher CDM (Hrsg) Diagnostic Histopathology of Tumors. Churchill Livingstone, London, S 1080–1097

    Google Scholar 

  9. Chen JD, Morrison C, Zhang C, Kahnoski K, Carpten JD, Teh BT (2003) Hyperparathyroidism-jaw tumour syndrome. J Intern Med 253:634–642

    Article  CAS  PubMed  Google Scholar 

  10. Cohen J, Gierlowski TC, Schneider AB (1990) A prospective study of hyperparathyroidism in individuals exposed to radiation in childhood. JAMA 264:581–584

    Article  CAS  PubMed  Google Scholar 

  11. Erickson LA, Jin L, Papotti M, Lloyd RV (2002) Oxyphil parathyroid carcinomas: a clinicopathologic and immunohistochemical study of 10 cases. Am J Surg Pathol 26:344–349

    Article  PubMed  Google Scholar 

  12. Fernandez-Ranvier GG, Khanafshar E, Jensen K, Zarnegar R, Lee J, Kebebew E, Duh QY, Clark OH (2007) Parathyroid carcinoma, atypical parathyroid adenoma, or parathyromatosis? Cancer 110:255–264

    Article  PubMed  Google Scholar 

  13. Fernandez-Ranvier GG, Khanafshar E, Tacha D, Wong M, Kebebew E, Duh QY, Clark OH (2009) Defining a molecular phenotype for benign and malignant parathyroid tumors. Cancer 115:334–344

    Article  PubMed  Google Scholar 

  14. Gill AJ, Clarkson A, Gimm O, Keil J, Dralle H, Howell VM, Marsh DJ (2006) Loss of nuclear expression of parafibromin distinguishes parathyroid carcinomas and hyperparathyroidism-jaw tumor (HPT-JT) syndrome-related adenomas from sporadic parathyroid adenomas and hyperplasias. Am J Surg Pathol 30:1140–1149

    Article  PubMed  Google Scholar 

  15. Gomes EM, Nunes RC, Lacativa PG, Almeida MH, Franco FM, Leal CT, Patricio Filho PJ, Farias ML, Goncalves MD (2007) Ectopic and extranumerary parathyroid glands location in patients with hyperparathyroidism secondary to end stage renal disease. Acta Cir Bras 22:105–109

    Article  PubMed  Google Scholar 

  16. Grimelius L, Johannson H (1998) The Parathyroid glands. In: Kovacs K, Asa S (Hrsg) Functional Endocrine Pathology. Blackwell Science, London, S 381–414

    Google Scholar 

  17. Hannan FM, Nesbit MA, Christie PT, Fratter C, Dudley NE, Sadler GP, Thakker RV (2008) Familial isolated primary hyperparathyroidism caused by mutations of the MEN1 gene. Nat Clin Pract Endocrinol Metab 4:53–58

    Article  CAS  PubMed  Google Scholar 

  18. Hendy GN, D’Souza-Li L, Yang B, Canaff L, Cole DE (2000) Mutations of the calcium-sensing receptor (CASR) in familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia. Hum Mutat 16:281–296

    Article  CAS  PubMed  Google Scholar 

  19. Herold G (2013) Nebenschilddrüse, Vitamin D-Stoffwechsel und Kalziumhaushalt. In: Herold G (Hrsg) Innere Medizin. Eigenverlag, Köln, S 764–776

    Google Scholar 

  20. Howell VM, Haven CJ, Kahnoski K, Khoo SK, Petillo D, Chen J, Fleuren GJ, Robinson BG, Delbridge LW, Philips J, Nelson AE, Krause U, Hammje K, Dralle H, Hoang-Vu C, Gimm O, Marsh DJ, Morreau H, Teh BT (2003) HRPT2 mutations are associated with malignancy in sporadic parathyroid tumours. J Med Genet 40:657–663

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  21. Hundahl SA, Fleming ID, Fremgen AM, Menck HR (1999) Two hundred eighty-six cases of parathyroid carcinoma treated in the U.S. between 1985–1995: a National Cancer Data Base Report. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer 86:538–544

    Article  CAS  PubMed  Google Scholar 

  22. Iacobone M, Masi G, Barzon L, Porzionato A, Macchi V, Ciarleglio FA, Palu G, De CR, Viel G, Favia G (2009) Hyperparathyroidism-jaw tumor syndrome: a report of three large kindred. Langenbecks Arch Surg 394:817–825

    Article  PubMed  Google Scholar 

  23. Juhlin CC, Nilsson IL, Johansson K, Haglund F, Villablanca A, Hoog A, Larsson C (2010) Parafibromin and APC as screening markers for malignant potential in atypical parathyroid adenomas. Endocr Pathol 21:166–177

    Article  CAS  PubMed  Google Scholar 

  24. Juhlin CC, Villablanca A, Sandelin K, Haglund F, Nordenstrom J, Forsberg L, Branstrom R, Obara T, Arnold A, Larsson C, Hoog A (2007) Parafibromin immunoreactivity: its use as an additional diagnostic marker for parathyroid tumor classification. Endocr Relat Cancer 14:501–512

    Article  CAS  PubMed  Google Scholar 

  25. Kebebew E, Arici C, Duh QY, Clark OH (2001) Localization and reoperation results for persistent and recurrent parathyroid carcinoma. Arch Surg 136:878–885

    Article  CAS  PubMed  Google Scholar 

  26. Kebebew E, Duh QY, Clark OH (2004) Tertiary hyperparathyroidism: histologic patterns of disease and results of parathyroidectomy. Arch Surg 139:974–977

    Article  PubMed  Google Scholar 

  27. Koea JB, Shaw JH (1999) Parathyroid cancer: biology and management. Surg Oncol 8:155–165

    Article  CAS  PubMed  Google Scholar 

  28. Koncz E, Schmid KW (2010) Multiple endocrine neoplasia type I. Pathologe 31:445–448

    Article  CAS  PubMed  Google Scholar 

  29. Lee PK, Jarosek SL, Virnig BA, Evasovich M, Tuttle TM (2007) Trends in the incidence and treatment of parathyroid cancer in the United States. Cancer 109:1736–1741

    Article  PubMed  Google Scholar 

  30. Lorenz K, Dralle H (2010) Intraoperative parathyroid hormone determination for primary hyperparathyroidism. Chirurg 81:636 (638–636, 642)

    Article  CAS  PubMed  Google Scholar 

  31. Marini F, Falchetti A, Del MF, Carbonell SS, Tognarini I, Luzi E, Brandi ML (2006) Multiple endocrine neoplasia type 2. Orphanet J Rare Dis 1:45

    Article  PubMed Central  PubMed  Google Scholar 

  32. McCauley LKMTJ (2012) Twenty-five years of PTHrP progress: from cancer hormone to multifunctional cytokine. J Bone Miner Res 27:1231–1239

    Article  CAS  PubMed  Google Scholar 

  33. Mizusawa N, Uchino S, Iwata T, Tsuyuguchi M, Suzuki Y, Mizukoshi T, Yamashita Y, Sakurai A, Suzuki S, Beniko M, Tahara H, Fujisawa M, Kamata N, Fujisawa K, Yashiro T, Nagao D, Golam HM, Sano T, Noguchi S, Yoshimoto K (2006) Genetic analyses in patients with familial isolated hyperparathyroidism and hyperparathyroidism-jaw tumour syndrome. Clin Endocrinol (Oxf) 65:9–16

    Article  CAS  Google Scholar 

  34. Pollak MR, Chou YH, Marx SJ, Steinmann B, Cole DE, Brandi ML, Papapoulos SE, Menko FH, Hendy GN, Brown EM (1994) Familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Effects of mutant gene dosage on phenotype. J Clin Invest 93:1108–1112

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  35. Ruda JM, Hollenbeak CS, Stack BC Jr (2005) A systematic review of the diagnosis and treatment of primary hyperparathyroidism from 1995 to 2003. Otolaryngol Head Neck Surg 132:359–372

    Article  PubMed  Google Scholar 

  36. Sawady J, Mendelsohn G, Sirota RL, Taxy JB (1989) The intrathyroidal hyperfunctioning parathyroid gland. Mod Pathol 2:652–657

    CAS  PubMed  Google Scholar 

  37. Schmid KW, Böcker W (1997) Nebenschilddrüsen. In: Remmele W (Hrsg) Pathologie. Springer-Verlag, Berlin, S 617–628

    Google Scholar 

  38. Schneider AB, Gierlowski TC, Shore-Freedman E, Stovall M, Ron E, Lubin J (1995) Dose-response relationships for radiation-induced hyperparathyroidism. J Clin Endocrinol Metab 80:254–257

    CAS  PubMed  Google Scholar 

  39. Shane E (2001) Clinical review 122: Parathyroid carcinoma. J Clin Endocrinol Metab 86:485–493

    Article  CAS  PubMed  Google Scholar 

  40. Sharretts JM, Kebebew E, Simonds WF (2010) Parathyroid cancer. Semin Oncol 37:580–590

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  41. Shattuck TM, Valimaki S, Obara T, Gaz RD, Clark OH, Shoback D, Wierman ME, Tojo K, Robbins CM, Carpten JD, Farnebo LO, Larsson C, Arnold A (2003) Somatic and germ-line mutations of the HRPT2 gene in sporadic parathyroid carcinoma. N Engl J Med 349:1722–1729

    Article  CAS  PubMed  Google Scholar 

  42. Sheu SY, Otterbach F, Frilling A, Schmid KW (2003) Hyperplasia and tumors of the parathyroid glands. Pathologe 24:373–381

    Article  PubMed  Google Scholar 

  43. Stojadinovic A, Hoos A, Nissan A, Dudas ME, Cordon-Cardo C, Shaha AR, Brennan MF, Singh B, Ghossein RA (2003) Parathyroid neoplasms: clinical, histopathological, and tissue microarray-based molecular analysis. Hum Pathol 34:54–64

    Article  PubMed  Google Scholar 

  44. Stracke S, Keller F, Steinbach G, Henne-Bruns D, Wuerl P (2009) Long-term outcome after total parathyroidectomy for the management of secondary hyperparathyroidism. Nephron Clin Pract 111:c102–c109

    Article  CAS  PubMed  Google Scholar 

  45. Talat N, Diaz-Cano S, Schulte KM (2011) Inflammatory diseases of the parathyroid gland. Histopathology 59:897–908

    Article  PubMed  Google Scholar 

  46. Wenig BM, Heffess CS, Adair CF (1997) Neoplasms of the Parathyroid Glands. Atlas of Endocrine Pathology. W.B. Saunders, Philadelphia, S 168–180

    Google Scholar 

  47. Woolner LB, Keatinger FR Jr., Black BM (1952) Tumors and hyperplasia of the parathyroid glands; a review of the pathological findings in 140 cases of primary hyperparathyroidism. Cancer 5:1069–1088

    Article  CAS  PubMed  Google Scholar 

  48. Wynne AG, van HJ, Carney JA, Fitzpatrick LA (1992) Parathyroid carcinoma: clinical and pathologic features in 43 patients. Medicine (Baltimore) 71:197–205

    Article  CAS  Google Scholar 

  49. Zhang Y, Nose V (2011) Endocrine tumors as part of inherited tumor syndromes. Adv Anat Pathol 18:206–218

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Institut für Pathologie, Universitätsklinikum Essen, Hufelandstr. 55, 45147, Essen, Deutschland

    Sien-Yi Sheu-Grabellus Dr. & Kurt Werner Schmid Prof. Dr.

Authors
  1. Sien-Yi Sheu-Grabellus Dr.
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  2. Kurt Werner Schmid Prof. Dr.
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Corresponding author

Correspondence to Sien-Yi Sheu-Grabellus Dr. .

Editor information

Editors and Affiliations

  1. Abt. Nephropathologie, Pathologisches Institut Universität Erlangen-Nürnberg, Erlangen, Germany

    Kerstin Amann

  2. Klinisches Institut für Pathologie, Medizinische Universität Wien Allg. Krankenhaus der Stadt Wien, Wien, Austria

    Renate Kain

  3. Konsultationszentrum für Pankreas- und Endokrine Tumoren, Institut für Pathologie, Ismaninger Str. 22, 81675, Technische Universität München Klinikum rechts der Isar, München, Germany

    Günter Klöppel

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Sheu-Grabellus, SY., Schmid, K.W. (2016). Nebenschilddrüsen. In: Amann, K., Kain, R., Klöppel, G. (eds) Pathologie. Pathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04566-0_20

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  • DOI: https://doi.org/10.1007/978-3-642-04566-0_20

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  • Print ISBN: 978-3-642-04565-3

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