Skip to main content
SpringerLink
Log in

Biological Activities of Kinetin

  • Chapter
Herbal Drugs: Ethnomedicine to Modern Medicine

Abstract

Kinetin (N6-furfuryladenine) is a cytokinin growth factor with several biological effects observed for human cells and fruit flies. It was given the name kinetin because of its ability to induce cell division. Kinetin is often used in plant cell and tissue culture for induction of callus formation (in conjunction with auxin) and to regenerate shoots from callus (with lower auxin concentration). Kinetin exists naturally in the DNA of almost all organisms tested so far, including human cells, and various plants. The mechanism of kinetin synthesis in DNA is thought to be via the production of furfural, an oxidative damage product of DNA deoxyribose, and it is quenched by the adenine base converting it into N6-furfuryladenine. Since 1994 kinetin has been thoroughly tested for its powerful antiaging effects in human skin cells and other systems. At present, kinetin is one of the most widely used components in numerous skin care cosmetics and cosmeceuticals. There are some reports published on other biological effects of kinetin in human beings, as an antiplatelet aggregation factor reducing thrombus formation, and its ability to correct genetic diseases of RNA missplicing. Kinetin was shown to be more effective in the improvement of skin texture, making it smoother and with a significant reduction in fine lines and wrinkles. It is a stable antioxidant that slows down the aging process.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Miller CO, Skoog F, Okumura FS, Von Saltza MH, Strong FM (1955) J Am Chem Soc 78:1375

    Article  Google Scholar 

  2. Barciszewski J, Siboska GE, Pedersen BO, Clark BFC, Rattan SI (1996) FEBS Lett 393:197

    Article  CAS  Google Scholar 

  3. Barciszewski J, Mielcarek M, Stobiecki M, Siborska G, Clark BFC (2000) Biochem Biophys Res Commun 179:69

    Article  CAS  Google Scholar 

  4. Ge L, Yong JW, Goh NK, Chia LS, Tan SN, Ong ES (2005) J Chromatogr B Analyt Technol Biomed Life Sci 829:26

    Article  CAS  Google Scholar 

  5. Barciszewski J, Siboska GE, Pedersen BO, Clark BFC, Rattan SI (1997a) Biochem Biophys Res Commun 238:317

    Google Scholar 

  6. Barciszewski J, Siboska GE, Pedersen BO, Clark BFC, Rattan SI (1997b) FEBS Lett 414:457

    Google Scholar 

  7. Wyszko E, Barciszewska MZ, Markiewicz M, Szymanski M, Markiewicz WT, Clark BFC, Barciszewski J (2003) Biochim Biophys Acta 1625:239

    CAS  Google Scholar 

  8. Mok DWS, Mok MC (2001) Annu Rev Plant Physiol Plant Mol Biol 52:89

    Article  CAS  Google Scholar 

  9. Hou B, Lim EK, Higgins GS, Bowles DJ (2004) J Biol Chem 279:47822

    Article  CAS  Google Scholar 

  10. Brzobohatý B, Moore I, Kristoffersen P, Bako L, Campos N, Schell J, Palme K. (1993) Science 262:1051

    Article  Google Scholar 

  11. Letham DS, Palni LMS (1983) Annu Rev Plant Physiol 34:163

    Article  CAS  Google Scholar 

  12. Armstrong DJ (1994) In: Mok DWS, Mok MC (eds) Cytokinins, Chemistry, Activity and Function. CRC Press, Boca Raton, FL, p 139

    Google Scholar 

  13. Molina1 RV, Castelló S, García-Luis A, Guardiola JL (2007) Plant Cell Tissue Organ Cult 89:131

    Article  CAS  Google Scholar 

  14. Papon N, Bremer J, Vansiri A, Andreu F, Rideau M, Creche J (2005) Planta Med 71:572

    Article  CAS  Google Scholar 

  15. Pasqua G, Monacelli B, Mulinacci N, Rinaldi S, Giaccherini C, Innocenti M, Vinceri FF (2005) Plant Physiol Biochem 43:293

    Article  CAS  Google Scholar 

  16. Yaronskaya EB, Gritskevitch ER, Trukhanovets NL, Averina NG (2007) Russian J Plant Physiol 54:388

    Article  CAS  Google Scholar 

  17. Shibaoka H. Thimann KV (1970) Plant Physiol 46:212

    CAS  Google Scholar 

  18. Debi RB, Taketa S, Ichii M (2005) J Plant Physiol 162:507

    Article  CAS  Google Scholar 

  19. Li X, Mo X, Shou H, Wu P (2006) Plant Cell Physiol 47:1112

    Article  CAS  Google Scholar 

  20. Filek M, Zȩ bala M, Szechyńska-Hebda M (2002) Z Naturforsch 57:696

    CAS  Google Scholar 

  21. Venis MA, Thomas EW, Barbier-Brygoo H, Ephritikhine G, Guen J (1990) Planta 182:232

    Article  CAS  Google Scholar 

  22. Gzyl-Malchera B, Filek M, Brezesinski G, Fischer A (2007) Z Naturforsch 62:55

    Google Scholar 

  23. Gaudino RJ, Pikaard CS (1997) J Biol Chem 272:6799

    Article  CAS  Google Scholar 

  24. Zhang K, Letham DS, John PC (1996) Planta 200:2

    Article  CAS  Google Scholar 

  25. Turck F, Zilbermann F, Kozma SC, Thomas G, Nagy F (2004) Plant Physiol 134:1527

    Article  CAS  Google Scholar 

  26. Balibrea LME, Garcia GMC, Fatima T, Ehness R, Lee TK, Proels R, Tanner W, Roitsch T (2004) Plant Cell 16:1276

    Article  Google Scholar 

  27. Koistinen KM, Soininen P, Venäläinen TA, Häyrinen J, Laatikainen R, Peräkylä M, Tervahauta AI, Kärenlampi SO (2005) Phytochemistry 66:2524

    Article  CAS  Google Scholar 

  28. Hurtado-Guerrero R, van Aalten DMF (2007) Chem Biol 14:589

    Article  CAS  Google Scholar 

  29. Barna B, Fodor J, Pogány M, Király Z (2003) Pest Manag Sci 59:549

    Article  CAS  Google Scholar 

  30. Balázs E, Barna B, Király Z (1976) Acta Phytopath Acad Sci Hung 11:1

    Google Scholar 

  31. Yang F, Simpson RB (1981) Proc Natl Acad Sci USA 78:4151

    Article  CAS  Google Scholar 

  32. Schumaker KS, Gizinski MJ (1995) J Biol Chem 270:23461

    Article  CAS  Google Scholar 

  33. Connett RJA, Hanke DE (1987) Planta 170:161

    Article  CAS  Google Scholar 

  34. Pharmawati M, Billington T, Gehring CA (1998) Cell Mol Life Sci 54:272

    Article  CAS  Google Scholar 

  35. Raman N, Elumalai S (1996) Ind J Exp Biol 34:577

    CAS  Google Scholar 

  36. Santos R, Hèrouart D, Sigaud S, Touati D, Puppo A (2001) Mol Plant Microbe Interact 14:86

    Article  CAS  Google Scholar 

  37. Rattan SI (2002) J Anti-aging Med 5:113

    Article  CAS  Google Scholar 

  38. Inoue H, Hirobe M (1986) Biochem Biophys Res Commun 137:372

    Article  CAS  Google Scholar 

  39. Sharma SP, Kaur P, Rattan SI (1995) Biochem Biophys Res Commun 216:1067

    Article  CAS  Google Scholar 

  40. Sharma SP, Kaur J, Rattan SI (1997) Biochem Mol Biol Int 41:869

    CAS  Google Scholar 

  41. Olsen A, Siboska GE, Clark BFC, Rattan SI (1999) Biochem Biophys Res Commun 265:499

    Article  CAS  Google Scholar 

  42. Pischetsrieder M, Seidel W, Munch G, Schinzel R (1999) Biochem Biophys Res Commun 264:544

    Article  CAS  Google Scholar 

  43. Yokosuka K, Park JS, Jimbo K, Yamada K, Sato K, Tsuru M, Takeuchi M, Yamagishi S, Nagata K (2006) J Neurosurg Spine 5:324

    Article  Google Scholar 

  44. Hamada Y, Araki N, Koh N, Nakamura J, Horiuchi S, Hotta N (1996) Biochem Biophys Res Commun 228:539

    Article  CAS  Google Scholar 

  45. Cervantes-Laurean D, Jacobson EL, Jacobson MK (1996) J Biol Chem 271:10461

    Article  CAS  Google Scholar 

  46. Verbeke P, Siboska GE, Clark BFC, Rattan SI (200) Biochem Biophys Res Commun 276:1265

    Article  CAS  Google Scholar 

  47. Rup PJ, Sohal SK, Kaur H (2006) J Environ Biol 27:579

    CAS  Google Scholar 

  48. Orr MF, McSwain B (1960) Cancer Res 20:1362

    CAS  Google Scholar 

  49. Kimura T, Doi K (2004) Rejuvenat Res 7:32

    Article  CAS  Google Scholar 

  50. Vicanova J, Bouez C, Lacroix S, Lindmark L, Damour O (2006) Ann NY Acad Sci 1067:337

    Article  CAS  Google Scholar 

  51. Berge U, Kristensen P, Rattan SI (2006) Ann NY Acad Sci 1067:332

    Article  CAS  Google Scholar 

  52. Orr MF, McSwain B (1957) Cancer 10:617

    Article  CAS  Google Scholar 

  53. Kowalska E (1992) Folia Morphol 51:109

    CAS  Google Scholar 

  54. Honma Y, Ishii Y (2002) Leuk Lymphoma 43:1729

    Article  CAS  Google Scholar 

  55. Honma Y (2003) Drug Dev Res 59:14

    Article  CAS  Google Scholar 

  56. Ishii Y, Hori Y, Sakai S, Honma Y (2002) Cell Growth Differ 13:19

    CAS  Google Scholar 

  57. Griffaut B, Bos R, Maurizis JC, Madelmont JC, Ledoigt G (2004) Int J Biol Macromol 34:271

    Article  CAS  Google Scholar 

  58. Ishii Y, Sakai S, Honma Y (2003) Biochim Biophys Acta 1643:11

    Article  CAS  Google Scholar 

  59. Becker T, Gerke V, Kube E, Weber K (1992) Eur J Biochem 207:541

    Article  CAS  Google Scholar 

  60. Sato N, Hitomi J (2002) Anat Rec 276:60

    Article  Google Scholar 

  61. Bullinger L, Dohner K, Bair E, Frohling S, Schlenk RF, Tibshirani R, Dohner H, Pollack JR (2004) N Engl J Med 350:1605

    Article  CAS  Google Scholar 

  62. Slaugenhaupt SA, Blumenfeld A, Gill SP, Leyne M, Mull J, Cuajungco MP, Liebert CB, Chadwick B, Idelson M, Reznik L, Robbins C, Makalowska I, Brownstein M, Krappmann D, Scheidereit C, Maayan C, Axelrod FB, Gusella JF (2001) Am J Hum Genet 68:598

    Article  CAS  Google Scholar 

  63. Hims MM, Ibrahim el C, Leyne M, Mull J, Liu L, Lazaro C, Shetty RS, Gill S, Gusella JF, Reed R, Slaugenhaupt SA (2007) J Mol Med 85:149

    Article  CAS  Google Scholar 

  64. Adunka O, Moustaklis E, Weber A, May A, von Ilberg C, Gstoettner W, Kierner AC (2003) ORL J Otorhinolaryngol Relat Spec 65:84

    Google Scholar 

  65. Chimini G, Chavrier P (2000) Nat Cell Biol 2:191

    Article  CAS  Google Scholar 

  66. Ivetic A, Ridley AJ (2004) Immunology 112:165

    Article  CAS  Google Scholar 

  67. Kamino H, Hiratsuka M, Toda T, Nishigaki R, Osaki M, Ito H, Inoue T, Oshimura M (2003) Cell Struct Funct 28:495

    Article  CAS  Google Scholar 

  68. Takahashi K, Sasaki T, Mammoto A, Takaishi K, Kameyama T, Tsukita S, Takai Y (1997) J Biol Chem 272:23371

    Article  CAS  Google Scholar 

  69. Lee JH, Chung KY, Bang D, Lee KH (2006) Proteomics 6:1351

    Article  CAS  Google Scholar 

  70. Wagner M, Hampel B, Bernhard D, Hala M, Zwerschke W, Jansen-Durr P (2001) Exp Gerontol 36:1327

    Article  CAS  Google Scholar 

  71. Sheu JR, Hsiao G, Shen MY, Chou CY, Lin CH, Chen TF, Chou DS (2003) Platelets ,v>14:189

    Google Scholar 

  72. Hsiao G, Shen MY, Lin KH, Chou CY, Tzu NH, Lin CH, Chou DS, Chen TF, Sheu JR (2003) Eur J Pharmacol 465:281

    Article  CAS  Google Scholar 

  73. Froldi G, Gallo U, Ragazzi E, Caparrotta L (1999) Planta Med 65:245

    Article  CAS  Google Scholar 

  74. Vesely DL, Hudson JL, Pipkin JL Jr, Pack LD, Meiners SE (1985) Endocrinology 116:1887

    Article  CAS  Google Scholar 

  75. Çelik I, Özbek H, Tülüce Y (2002) J Biol 26:193

    Google Scholar 

  76. Ciftci M, Demir Y, Ozmen I, Atici O (2003) J Enzyme Inhib Med Chem 18:71

    Article  CAS  Google Scholar 

  77. Barciszewski J, Otzen D, Rattan SI, Clark BFC (1994) Biochem Int 28:805

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute for Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61–704 Poznan, Poland

    Brian F.C. Clark, Frank Massino & Jan Barciszewski

Authors
  1. Kalina Duszka
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Brian F.C. Clark
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Frank Massino
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jan Barciszewski
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Botany Dept, M.L. Sukhadia University, Udaipur-313002, India

    K.G. Ramawat (Prof. Dr.) (Prof. Dr.)

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Duszka, K., Clark, B.F., Massino, F., Barciszewski, J. (2009). Biological Activities of Kinetin. In: Ramawat, K. (eds) Herbal Drugs: Ethnomedicine to Modern Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-79116-4_20

Download citation

Publish with us

Policies and ethics

Search

Navigation