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Degenerative Joint Disease Activated Osteoarthrosis Deformans: Hip, Knee, Shoulder and Other Joints

  • Chapter
Radiotherapy for Non-Malignant Disorders

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

Osteoarthritis is a chronic, degenerative disorder of unknown cause characterized by the gradual loss of articular cartilage. It is the most prevalent disease in the western societies, with a worldwide distribution. As a cause of disability (such as walking and stair climbing) in the elderly in the west, osteoarthritis is second only to vascular diseases. Altogether 10%-15% of adults over 60 years have some degree of osteoarthritis, and with an aging population, it is becoming an increasingly important disease. Presently, most of our knowledge of the etiology and epidemiology of osteoarthritis is from observational studies. Very little is really known with certainty about the underlying mechanism(s) of osteoarthritis, why its course varies from person to person, and why it progresses rapidly in some, but not in others. Our diagnostic measures are based on clinical findings and clumsy radiological methods, and none of the current available therapeutic interventions are curative, but rather symptomatic. However, it is important to treat osteoarthritis effectively using a multidisciplinary approach tailored to the patient’s needs, and furthermore to develop robust outcome measures in order to assess the efficacy of any disease-modifying osteoarthritis treatment options in large-scale multicenter clinical trials.

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  1. Radiological Center, Clinic and Policlinic of Radiotherapy and Radiation Oncology, University Leipzig, Stephanstrasse 9a, 04103, Leipzig, Germany

    Guido Hildebrandt MD (Privatdozent) & Friedrich-Hugo Kamprad MD (Professor)

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  1. Guido Hildebrandt MD
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  1. Department of Radiation Oncology and Therapeutic Radiology, Alfried-Krupp-Hospital, Alfried-Krupp-Strasse 21, Postfach 10 22 43, 45117, Essen, Germany

    Michael Heinrich Seegenschmiedt MD (Professor) (Professor)

  2. Strahlenklinik Klinikum Duisburg, Zu den Rehwiesen 9, 47055, Duisburg, Germany

    Hans-Bruno Makoski MD (Professor) (Professor)

  3. Department of Radiation Biology, St. Bartolomew’s Medical College, Charterhouse Square, London, EC1M 6BQ, UK

    Klaus-Rüdiger Trott MD (Professor) (Professor)

  4. Hylda Cohn/American Cancer Society, USA

    Luther W. Brady MD (Professor of Clinical Oncology, and Professor, Department of Radiation Oncology Distinguished University Professor) (Professor of Clinical Oncology, and Professor, Department of Radiation Oncology Distinguished University Professor)

  5. College of Medicine, Drexel University, Broad & Vine Sts., Mail Stop 200, Philadelphia, PA, 19102-1192, USA

    Luther W. Brady MD (Professor of Clinical Oncology, and Professor, Department of Radiation Oncology Distinguished University Professor) (Professor of Clinical Oncology, and Professor, Department of Radiation Oncology Distinguished University Professor)

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Hildebrandt, G., Kamprad, FH. (2008). Degenerative Joint Disease Activated Osteoarthrosis Deformans: Hip, Knee, Shoulder and Other Joints. In: Seegenschmiedt, M.H., Makoski, HB., Trott, KR., Brady, L.W. (eds) Radiotherapy for Non-Malignant Disorders. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68943-0_17

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