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Signalling from Tyrosine Kinases in the Developing Neurons and Glia of the Mammalian Brain

  • Chapter
Mouse Brain Development

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 30))

  • 498 Accesses

Abstract

The events that occur during the transition from proliferation to differentiation in the developing brain have attracted increasing attention, revealing the existence of multipotential central nervous system (CNS) stem cells and identifying the genes and factors that control their maturation and survival (Gage et al. 1995; Gage 1998; McKay 1997; Mehler 1997; Cattaneo and Pelicci 1998). Together with increasing our knowledge of the basic biology of brain development, this large body of data has also set the stage for new approaches to neurodegeneration, whereby genes encoding for pro-survival factors or in vitro expanded/differentiated CNS donor cells are vehicled to the diseased brain (Cattaneo and McKay 1991; Brustle and McKay 1996; Martinez-Serrano and Bjorklund 1997). Within a very brief period, this strong convergence of interests between basic and pre-clinical research has highlighted the way in which soluble growth factors, including the neurotrophins and cytokines, are molecules that have powerful effects on the ability of immature and mature brain cells to divide and/or to survive and differentiate (Eide et al. 1993; Mehler and Kessler 1994, 1997; Reichardt and Farinas 1997).

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  1. Institute of Pharmacological Sciences, University of Milano, Via Balzaretti 9, 20133, Milano, Italy

    Elena Cattaneo

  2. Laboratory of Molecular Biology, Department of Physiological Sciences, University of Catania, Viale Andrea Doria 6, 95125, Catania, Italy

    Massimo Gulisano

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  1. Elena Cattaneo
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  1. Neurobiology Unit, University of Namur Medical School, 61, rue de Bruxelles, B-5000, Namur, Belgium

    André M. Goffinet

  2. Section of Neurobiology, Yale University School of Medicine, 333, Cedar Street, 06510, New Haven, CT, USA

    Pasko Rakic

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© 2000 Springer-Verlag Berlin Heidelberg

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Cattaneo, E., Gulisano, M. (2000). Signalling from Tyrosine Kinases in the Developing Neurons and Glia of the Mammalian Brain. In: Goffinet, A.M., Rakic, P. (eds) Mouse Brain Development. Results and Problems in Cell Differentiation, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-48002-0_9

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  • DOI: https://doi.org/10.1007/978-3-540-48002-0_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-53684-7

  • Online ISBN: 978-3-540-48002-0

  • eBook Packages: Springer Book Archive

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