Mouse Brain Development

1. Front Matter

   Pages I-XIV

   PDF

2. From Spontaneous to Induced Neurological Mutations: A Personal Witness of the Ascent of the Mouse Model

   • Pasko Rakic

   Pages 1-19

3. Mapping Genes that Modulate Mouse Brain Development: A Quantitative Genetic Approach

   • Robert W. Williams

   Pages 21-49

4. Genetic Interactions During Hindbrain Segmentation in the Mouse Embryo

   • Paul A. Trainor, Miguel Manzanares, Robb Krumlauf

   Pages 51-89

5. Neurogenetic Compartments of the Mouse Diencephalon and some Characteristic Gene Expression Patterns

   • Salvador Martínez, Luis Puelles

   Pages 91-106

6. Neuronogenesis and the Early Events of Neocortical Histogenesis

   • V. S. Caviness Jr, T. Takahashi, R. S. Nowakowski

   Pages 107-143

7. Programmed Cell Death in Mouse Brain Development

   • Chia-Yi Kuan, Richard A. Flavell, Pasko Rakic

   Pages 145-162

8. Neurotrophic Factors: Versatile Signals for Cell-Cell Communication in the Nervous System

   • Carlos F. Ibáñez

   Pages 163-188

9. Growth Factor Influences on the Production and Migration of Cortical Neurons

   • Janice E. Brunstrom, Alan L. Pearlman

   Pages 189-215

10. Signalling from Tyrosine Kinases in the Developing Neurons and Glia of the Mammalian Brain

    • Elena Cattaneo, Massimo Gulisano

    Pages 217-240

11. The Role of the p35/cdk5 Kinase in Cortical Development

    • Young T. Kwon, Li-Huei Tsai

    Pages 241-253

12. The Reelin-Signaling Pathway and Mouse Cortical Development

    • Isabelle Bar, Catherine Lambert de Rouvroit, André M. Goffinet

    Pages 255-276

13. The Subpial Granular Layer in the Developing Cerebral Cortex of Rodents

    • Gundela Meyer, Rafael Castro, José Miguel Soria, Alfonso Fairén

    Pages 277-291

14. Development of Thalamocortical Projections in Normal and Mutant Mice

    • Zoltán Molnár, Anthony J. Hannan

    Pages 293-332

15. Back Matter

    Pages 333-339

    PDF

Our understanding of the molecular mechanisms involved in mammalian brain development remains limited. However, the last few years have wit­ nessed a quantum leap in our knowledge, due to technological improve­ ments, particularly in molecular genetics. Despite this progress, the available body of data remains mostly phenomenological and reveals very little about the grammar that organizes the molecular dictionary to articulate a pheno­ type. Nevertheless, the recent progress in genetics will allow us to contem­ plate, for the first time, the integration of observation into a coherent view of brain development. Clearly, this may be a major challenge for the next century, and arguably is the most important task of contemporary develop­ mental biology. The purpose of the present book is to provide an overview that syn­ thesizes up-to-date information on selected aspects of mouse brain devel­ opment. Given the format, it was not possible to cover all aspects of brain development, and many important subjects are missing. The selected themes are, to a certain extent, subjective and reflect the interests of the contributing authors. Examples of major themes that are not covered are peripheral nervous system development, including myelination, the development of the hippocampus and several other CNS structures, as well as the developmental function of some important morphoregulatory molecules.

• Apoptose
• Apoptosis
• Brain Development
• Cerebral Cortex
• Glia
• Kortex
• Maus
• Neuron
• Neuronen
• Neurons
• cortex
• gene expression
• influence
• migration
• mouse

• Neurobiology Unit, University of Namur Medical School, Namur, Belgium

  André M. Goffinet

• Section of Neurobiology, Yale University School of Medicine, New Haven, USA

  Pasko Rakic

Policies and ethics