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Genetic Interactions During Hindbrain Segmentation in the Mouse Embryo

  • Chapter
Mouse Brain Development

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 30))

Abstract

The process by which a simple flat sheet of cells in the early embryo proliferates and differentiates into the central nervous system (CNS) is one of the most fascinating problems of modern biology. This is not only because of the importance of the CNS in adult life, but also because of the enormous quantity and complexity of cell connections that have to be established with extraordinary precision. Large-scale genetic screens in invertebrate model systems such as Caenorhabditis elegans and Drosophila have revealed in significant detail the genetic components required for early CNS development and some aspects of the basic programme appear to have been conserved throughout evolution in the animal kingdom. In this chapter we will detail our current understanding of the development of the early vertebrate nervous system, with particular reference to the mouse hindbrain.

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  1. Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK

    Robb Krumlauf

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  1. Paul A. Trainor
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  2. Miguel Manzanares
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  1. Neurobiology Unit, University of Namur Medical School, 61, rue de Bruxelles, B-5000, Namur, Belgium

    André M. Goffinet

  2. Section of Neurobiology, Yale University School of Medicine, 333, Cedar Street, 06510, New Haven, CT, USA

    Pasko Rakic

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Trainor, P.A., Manzanares, M., Krumlauf, R. (2000). Genetic Interactions During Hindbrain Segmentation in the Mouse Embryo. In: Goffinet, A.M., Rakic, P. (eds) Mouse Brain Development. Results and Problems in Cell Differentiation, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-48002-0_3

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