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Characteristics of Mesenchymal Stem Cells Derived from Amniotic Membrane: A Potential Candidate for Stem Cell-Based Therapy

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Perinatal Tissue-Derived Stem Cells

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Nowadays, mesenchymal stem cells (MSCs) have elevated the hopes of patients excruciated with incurable and/or disabling diseases. Amniotic membrane-derived mesenchymal stem cells (AMSCs) have considerable advantages over clinically administrated MSCs like bone marrow in terms of availability, no ethical concerns, less DNA damage, higher proliferation ability that introduce them as a potential stem cells with clinical applications in the promising field of regenerative medicine. In this chapter, we analyzed the characteristics of AMSCs in terms of critical points considered for clinical application especially in comparison with MSCs retrieved from other sources. We also describe previous studies concerning the therapeutic applications and discuss potential pitfalls in research for AMSCs.

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Study Finding/Competing Interest

The authors indicate no potential conflict of interest.

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Authors and Affiliations

  1. Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran

    Somaieh Kazemnejad Ph.D. & Manijeh Khanmohammadi

  2. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

    Amir-Hassan Zarnani

  3. Immunology Research Center, Iran University of Medical Sciences, Tehran, Iran

    Amir-Hassan Zarnani & Mohammad Reza Bolouri

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  1. Somaieh Kazemnejad Ph.D.
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  2. Manijeh Khanmohammadi
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  3. Amir-Hassan Zarnani
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  4. Mohammad Reza Bolouri
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Correspondence to Somaieh Kazemnejad Ph.D. .

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  1. Endocrinology and Metabolism Research Center Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences & Brain and Spinal Cord Injury Research Center Tehran University of Medical Sciences, Tehran, Iran

    Babak Arjmand

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Kazemnejad, S., Khanmohammadi, M., Zarnani, AH., Bolouri, M.R. (2016). Characteristics of Mesenchymal Stem Cells Derived from Amniotic Membrane: A Potential Candidate for Stem Cell-Based Therapy. In: Arjmand, B. (eds) Perinatal Tissue-Derived Stem Cells. Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-46410-7_7

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