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Positive Feedback Loops Between Inflammatory, Bone and Cancer Cells During Metastatic Niche Construction

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Systems Biology of Tumor Microenvironment

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 936))

Abstract

Bone, which includes several cell populations and numerous cytokines and chemokines that provide cell-cell signaling, is a common destination for many cancer metastases. Bone metastasis skews this signaling to develop vicious cycles between immune, bone and cancer populations that lead to abnormal bone remodeling during cancer niche construction. Temporal models utilize positive feedback systems as an integrative tool providing insights into the rate-limiting processes that determine multiple stages of the bone metastasis. We develop a logical-transient-threshold framework by linking temporal responses of the cancer, bone and immune systems through macrophages during ecological niche construction of cancer in host bone.

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Notes

  1. 1.

    A second order behavior of variable x under external stimuli f(t) is given by a second order linear differential system as \(\frac{d^{2}x} {dt^{2}} + a_{1}\frac{dx} {dt} + a_{2}x = f(t)\).

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Acknowledgements

NCI Grant numbers: U54CA143803, CA163124, CA093900, CA143055 supported this study.

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Authors and Affiliations

  1. Brady Urological Institute, Johns Hopkins Hospital, Baltimore, MD, USA

    Ardeshir Kianercy & Kenneth J. Pienta

  2. Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA

    Ardeshir Kianercy

Authors
  1. Ardeshir Kianercy
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  2. Kenneth J. Pienta
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Corresponding author

Correspondence to Kenneth J. Pienta .

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Editors and Affiliations

  1. H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA

    Katarzyna A. Rejniak

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Kianercy, A., Pienta, K.J. (2016). Positive Feedback Loops Between Inflammatory, Bone and Cancer Cells During Metastatic Niche Construction. In: Rejniak, K. (eds) Systems Biology of Tumor Microenvironment. Advances in Experimental Medicine and Biology, vol 936. Springer, Cham. https://doi.org/10.1007/978-3-319-42023-3_7

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