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The Role of Bone Marrow-Derived Mesenchymal Stem Cells in Sports Injuries

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Bone and Cartilage Regeneration

Part of the book series: Stem Cells in Clinical Applications ((SCCA))

Abstract

Bone marrow-derived mesenchymal stem cells (BM-MSCs) have been used as treatment to various soft tissues prone to sport-related injuries. Injecting BM-MSCs directly into the defect is one of the techniques that have been applied. Although it is a method of minimal invasiveness, it has limitations that have been addressed with the utilisation of scaffolds. Collagen gel, poly-lactide-co-glycolide (PLGE) and coral are some of the scaffold options, with individual advantages and flaws under research. BM-MSCs are a unique tissue engineering raw material because they are harvested with minimally invasive aspiration, their proliferation rate in vitro is adequate and they preserve their potential for differentiation. Research so far has been mainly limited to small animals. Application and testing on large animals and humans are necessary.

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Authors and Affiliations

  1. Department of Trauma & Orthopaedics, Barts Health NHS Trust, The Royal London Hospital, Whitechapel, London, E1 1BB, UK

    Alex Vris & Nick Aresti

  2. Division of Trauma and Orthopaedics, University of Cambridge, Addenbrooke’s Hospital, Cambridge, CB22QQ, UK

    Wasim S. Khan

  3. Department of Trauma and Orthopaedics, Buckinghamshire NHS Trust, Stoke Mandeville Hospital, Aylesbury, HP21 8BD, UK

    Atif A. Malik

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  1. Alex Vris
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  2. Nick Aresti
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  3. Wasim S. Khan
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  4. Atif A. Malik
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Correspondence to Atif A. Malik .

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Editors and Affiliations

  1. Laboratory of Stem Cell Research and Application, University of Science Vietnam National University, Ho Chi Minh City, Vietnam

    Phuc Van Pham

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Vris, A., Aresti, N., Khan, W.S., Malik, A.A. (2016). The Role of Bone Marrow-Derived Mesenchymal Stem Cells in Sports Injuries. In: Pham, P. (eds) Bone and Cartilage Regeneration. Stem Cells in Clinical Applications. Springer, Cham. https://doi.org/10.1007/978-3-319-40144-7_14

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