Skip to main content
SpringerLink
Log in

The Kiwifruit Allergome

  • Chapter
  • First Online:
The Kiwifruit Genome

Part of the book series: Compendium of Plant Genomes ((CPG))

  • 1357 Accesses

Abstract

This chapter draws upon the recently released genome sequence of the yellow-fleshed, red-centred A. chinensis var. chinensis cultivar ‘Hongyang’ to prepare an inventory of allergen proteins in this genotype, termed the ‘allergome’. It will be of use to clinicians and industry for better management of kiwifruit allergy. By combining this information with publicly available transcriptomic data for a ‘Hongyang’ whole fruit developmental series, a draft list of relevant fruit allergen proteins of ‘Hongyang’ is presented. The reference to ‘draft’ list is used because the ‘Hongyang’ genome is still only 80 % assembled, and so a number of potential allergens remain unmapped. This chapter presents a number of interesting findings including the reason for the low actinidin (Act c 1) content of ‘Hongyang’, the surprisingly small gene family of Bet v 1-like allergens (Act c 8) together with their likely hypoallergenicity, the intriguing and diverse family of kiwellins (Act c 5) of which transcripts of only one is present in fruit but is also the most expressed gene in fruit, the identification of the Act c 3 locus (previously for which there was only a short peptide sequence), the diversity of the thaumatin-like protein (Act c 2) and the profilin (Act c 9) gene families, and the lack of non-specific lipid transfer protein allergen (Act c 10) in ‘Hongyang’ fruit. In addition to these findings, a high degree of clustering was found for many allergen gene classes and the implications for breeding with regard to allergenicity are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  • Alemán A, Sastre J, Quirce S, de las Heras M, Carnés J, Fernández-Caldas E et al (2004) Allergy to kiwi: a double-blind, placebo-controlled food challenge study in patients from a birch-free area. J Allergy Clin Immunol 113(3):543–550. doi:10.1016/j.jaci.2003.11.043

    Google Scholar 

  • Altschul SF, Madden TL, Schäffer AA, Zhang J, Zhang Z, Miller W et al (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25(17):3389–3402

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Arai S, Matsumoto I, Emori Y, Abe K (2002) Plant seed cystatins and their target enzymes of endogenous and exogenous origin. J Agric Food Chem 50(22):6612–6617

    Article  CAS  PubMed  Google Scholar 

  • Asero R, Mistrello G, Roncarolo D, de Vries SC, Gautier M-F, Ciurana CLF et al (2000) Lipid transfer protein: a pan-allergen in plant-derived foods that is highly resistant to pepsin digestion. Int Arch Allergy Immunol 122(1):20–32

    Article  CAS  PubMed  Google Scholar 

  • Baeza NC, Gomez-Casado C, Murua-Garcia A, Garrido-Arandia M, Gonzalez-Melendi P, Sanchez-Monge R et al (2014). Alt a 1, Alternaria major allergen, interacts with Act d 2, kiwi major allergen. Allergy 69:383–383

    Google Scholar 

  • Baker EN (1977) Structure of actinidin: details of the polypeptide chain conformation and active site from an electron density map at 2-8 Å resolution. J Mol Biol 115(3):263–277

    Article  CAS  PubMed  Google Scholar 

  • Beers EP, Jones AM, Dickerman AW (2004) The S8 serine, C1A cysteine and Al aspartic protease families in Arabidopsis. Phytochemistry 65(1):43–58

    Article  CAS  PubMed  Google Scholar 

  • Bernardi ML, Picone D, Tuppo L, Giangrieco I, Petrella G, Palazzo P et al (2010) Physico-chemical features of the environment affect the protein conformation and the immunoglobulin E reactivity of kiwellin (Act d 5). Clin Exp Allergy 40(12):1819–1826

    Article  CAS  PubMed  Google Scholar 

  • Bublin M, Mari A, Ebner C, Knulst A, Scheiner O, Hoffmann-Sommergruber K et al (2004) IgE sensitization profiles toward green and gold kiwifruits differ among patients allergic to kiwifruit from 3 European countries. J Allergy Clin Immunol 114(5):1169–1175

    Article  CAS  PubMed  Google Scholar 

  • Bublin M, Radauer C, Lebens A, Knulst A, Scheiner O, Breiteneder H (2006) Purification and partial characterisation of a 40 kDa allergen from kiwifruit (Actinidia deliciosa). In: XXV congress of the European Academy of Allergology and Clinical Immunology, 10–14 June 2006, Vienna, Austria

    Google Scholar 

  • Bublin M, Radauer C, Knulst A, Wagner S, Scheiner O, Mackie AR et al (2008) Effects of gastrointestinal digestion and heating on the allergenicity of the kiwi allergens Act d 1, actinidin, and Act d 2, a thaumatin-like protein. Mol Nutr Food Res 52(10):1130–1139

    Article  CAS  PubMed  Google Scholar 

  • Bublin M, Pfister M, Radauer C, Oberhuber C, Bulley S, DeWitt ÅM et al (2010) Component-resolved diagnosis of kiwifruit allergy with purified natural and recombinant kiwifruit allergens. J Allergy Clin Immunol 125(3):687–694. doi:10.1016/j.jaci.2009.10.017

    Article  CAS  PubMed  Google Scholar 

  • Bublin M, Dennstedt S, Buchegger M, Ciardiello MA, Bernardi ML, Tuppo L et al (2011) The performance of a component-based allergen microarray for the diagnosis of kiwifruit allergy. Clin Exp Allergy 41(1):129–136

    Article  CAS  PubMed  Google Scholar 

  • Burney PGJ, Potts J, Kummeling I, Mills ENC, Clausen M, Dubakiene R et al (2014) The prevalence and distribution of food sensitization in European adults. Allergy 69(3):365–371

    Article  CAS  PubMed  Google Scholar 

  • Carne A, Moore CH (1978) The amino acid sequence of the tryptic peptides from actinidin, a proteolytic enzyme from the fruit of Actinidia chinensis. Biochem J 173(1):73–83

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Čavić M, Grozdanović M, Bajić A, Srdić-Rajić T, Anđjus PR, Gavrović-Jankulović M (2012) Actinidin, a protease from kiwifruit, induces changes in morphology and adhesion of T84 intestinal epithelial cells. Phytochemistry 77:46–52

    Article  PubMed  Google Scholar 

  • Čavić M, Grozdanovic MM, Bajic A, Jankovic R, Andjus PR, Gavrovic-Jankulovic M (2014) The effect of kiwifruit (Actinidia deliciosa) cysteine protease actinidin on the occludin tight junction network in T84 intestinal epithelial cells. Food Chem Toxicol 72:61–68

    Article  PubMed  Google Scholar 

  • Choi Y, Ju S, Chang H (2015) Food allergy knowledge, perception of food allergy labeling, and level of dietary practice: a comparison between children with and without food allergy experience. Nutr Res Pract 9(1):92–98

    Article  PubMed  PubMed Central  Google Scholar 

  • Chruszcz M, Ciardiello MA, Osinski T, Majorek KA, Giangrieco I, Font J, Breiteneder H, Thalassinos K, Minor W (2013) Structural and bioinformatic analysis of the kiwifruit allergen Act d 11, a member of the family of ripening-related proteins. Mol Immunol 56(4):794–803

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ciacci C, Russo I, Bucci C, Iovino P, Pellegrini L, Giangrieco I, Tamburrini M, Ciardiello MA (2014) The kiwi fruit peptide kissper displays anti-inflammatory and anti-oxidant effects in in-vitro and ex-vivo human intestinal models. Clin Exp Immunol 175(3):476–484

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ciardiello MA, Meleleo D, Saviano G, Crescenzo R, Carratore V, Camardella L, Gallucci E, Micelli S, Tancredi T, Picone D, Tamburrini M (2008) Kissper, a kiwi fruit peptide with channel-like activity: structural and functional features. J Pept Sci 14(6):742–754

    Article  CAS  PubMed  Google Scholar 

  • D’Avino R, Bernardi ML, Wallner M, Palazzo P, Camardella L, Tuppo L et al (2011) Kiwifruit Act d 11 is the first member of the ripening-related protein family identified as an allergen. Allergy 66:870–877

    Article  PubMed  Google Scholar 

  • Dias RP, Summerfield A, Khakoo GA (2008) Food hypersensitivity among Caucasian and non-Caucasian children. Pediatr Allergy Immunol 19(1):86–89

    Article  PubMed  Google Scholar 

  • Falliers CJ (1983) Anaphylaxis to kiwi fruit and related “exotic” items. J Asthma 20(3):193–196

    Article  CAS  PubMed  Google Scholar 

  • Fernández-Rivas M, Bolhaar S, González-Mancebo E, Asero R, van Leeuwen A, Bohle B et al (2006) Apple allergy across Europe: How allergen sensitization profiles determine the clinical expression of allergies to plant foods. J Allergy Clin Immunol 118(2):481–488

    Article  PubMed  Google Scholar 

  • Ferreira F, Hawranek T, Gruber P, Wopfner N, Mari A (2004) Allergic cross-reactivity: from gene to the clinic. Allergy 59(3):243–267. doi:10.1046/j.1398-9995.2003.00407.x

    Article  CAS  PubMed  Google Scholar 

  • Fine AJ (1981) Hypersensitivity reaction to kiwi fruit (Chinese gooseberry, Actinidia chinensis). J Allergy Clin Immunol 68(3):235–237

    Article  CAS  PubMed  Google Scholar 

  • Fraser LG, Tsang GK, Datson PM, De Silva HN, Harvey CF, Gill GP et al (2009) A gene-rich linkage map in the dioecious species Actinidia chinensis (kiwifruit) reveals putative X/Y sex-determining chromosomes. BMC Genom 10:102. doi:10.1186/1471-2164-10-102

    Article  Google Scholar 

  • Freye HB (1989) Life-threatening anaphylaxis to kiwi fruit and the prevalence of kiwi fruit sensitivity in the United States. Allergologie 12:89–90

    Google Scholar 

  • Furmonaviciene R, Tighe PJ, Clark MR, Sewell HF, Shakib F (1999) The use of phage-peptide libraries to define the epitope specificity of a mouse monoclonal anti-Der p 1 antibody representative of a major component of the human immunoglobulin E anti-Der p 1 response. Clin Exp Allergy 29(11):1563–1571

    Article  CAS  PubMed  Google Scholar 

  • Furmonaviciene R, Sewell HF, Shakib F (2000) Comparative molecular modelling identifies a common putative IgE epitope on cysteine protease allergens of diverse sources. Clin Exp Allergy: J Br Soc Allergy Clin Immunol 30(9):1307–1313

    Article  CAS  Google Scholar 

  • Garcia BE, Delacuesta CG, Santos F, Feliu X, Córdoba H (1989) A rare case of food allergy - monosensitivity to kiwi (Actinidia chinensis). Allergol Immunopath 17(4):217–218

    CAS  Google Scholar 

  • Gavrović-Jankulović M, Cirković T, Vucković O, Atanasković-Marković M, Petersen A, Gojgi et al (2002a) Isolation and biochemical characterization of a thaumatin-like kiwi allergen. J Allergy Clin Immunol 110(5):805–810

    Google Scholar 

  • Gavrović-Jankulović M, Velickovic TC, Jankov RM, Petersen A, Vuckovic O, Burazer L (2002b) Biochemical characterization of thaumatin-like kiwi allergen. Allergy 57:285–285

    Google Scholar 

  • Gawchik SM (2011) Latex allergy. Mt Sinai J Med 78(5):759–772

    Article  PubMed  Google Scholar 

  • Gómez-Casado C, Murua-Garcia A, Garrido-Arandia M, González-Melendi P, Sánchez-Monge R, Barber D et al (2014) Alt a 1 from Alternaria interacts with PR5 thaumatin-like proteins. FEBS Lett 588(9):1501–1508

    Article  PubMed  Google Scholar 

  • Grozdanovic M, Popovic M, Polovic N, Burazer L, Vuckovic O, Atanaskovic-Markovic M et al (2012) Evaluation of IgE reactivity of active and thermally inactivated actinidin, a biomarker of kiwifruit allergy. Food Chem Toxicol 50(3–4):1013–1018

    Article  CAS  PubMed  Google Scholar 

  • Hauser M, Roulias A, Ferreira F, Egger M (2010) Panallergens and their impact on the allergic patient. Allergy Asthma Clin Immunol: Official J Can Soc Allergy Clin Immunol 6(1):1. doi:10.1186/1710-1492-6-1

    Article  Google Scholar 

  • Hoffmann-Sommergruber K, Pfeifer S, Bublin M (2015) Applications of molecular diagnostic testing in food allergy. Curr Allergy Asthma Rep 15(9):56. doi:10.1007/s11882-015-0557-6

    Article  PubMed  PubMed Central  Google Scholar 

  • Huang S, Ding J, Deng D, Tang W, Sun H, Liu D et al (2013) Draft genome of the kiwifruit Actinidia chinensis. Nat Comm 4:2640. doi:10.1038/ncomms3640

    Google Scholar 

  • Kaur L, Rutherfurd SM, Moughan PJ, Drummond L, Boland MJ (2010) Actinidin enhances protein digestion in the small intestine as assessed using an in vitro digestion model. J Agric Food Chem 58(8):5074–5080

    Article  CAS  PubMed  Google Scholar 

  • Kim KT, Hussain H (1999) Prevalence of food allergy in 137 latex-allergic patients. Allergy Asthma Proc 20(2):95–97

    Article  CAS  PubMed  Google Scholar 

  • Kumar HGA, Venkatesh YP (2014) In silico analyses of structural and allergenicity features of sapodilla (Manilkara zapota) acidic thaumatin-like protein in comparison with allergenic plant TLPs. Mol Immunol 57(2):119–128

    Article  Google Scholar 

  • Le T-M, Fritsche P, Bublin M, Oberhuber C, Bulley S, van Hoffen E et al (2011) Differences in the allergenicity of 6 different kiwifruit cultivars analyzed by prick-to-prick testing, open food challenges, and ELISA. J Allergy Clin Immunol 127(3):677–679.e2. doi:10.1016/j.jaci.2010.10.003

    Google Scholar 

  • Le T-M, Bublin M, Breiteneder H, Fernández-Rivas M, Asero R, Ballmer-Weber B et al (2013) Kiwifruit allergy across Europe: clinical manifestation and IgE recognition patterns to kiwifruit allergens. J Allergy Clin Immunol 131(1):164–171. doi:10.1016/j.jaci.2012.09.009

    Article  CAS  PubMed  Google Scholar 

  • Lee S-Y (2013) IgE mediated food allergy in Korean children: focused on plant food allergy. Asia Pac Allergy 3(1):15–22

    Article  PubMed  PubMed Central  Google Scholar 

  • Leitner A, Vogel M, Radauer C, Breiteneder H, Stadler BM, Scheiner O et al (1998) A mimotope defined by phage display inhibits IgE binding to the plant panallergen profilin. Eur J Immunol 28(9):2921–2927

    Article  CAS  PubMed  Google Scholar 

  • Li W, Liu Y, Zeng S, Xiao G, Wang G, Wang Y et al (2015) Gene expression profiling of development and anthocyanin accumulation in kiwifruit (Actinidia) based on transcriptome sequencing. PLoS ONE 10(8):e0136439. doi:10.1371/journal.pone.0136439

    Article  PubMed  PubMed Central  Google Scholar 

  • Lucas JS, Lewis SA, Hourihane JO’B (2003) Kiwi fruit allergy: a review. Pediatr Allergy Immunol 14(6):420–428. doi:10.1046/j.0905-6157.2003.00095.x

    Google Scholar 

  • Lucas JSA, Grimshaw KEC, Collins K, Warner JO, Hourihane JO’B (2004) Kiwi fruit is a significant allergen and is associated with differing patterns of reactivity in children and adults. Clin Exp Allergy 34(7):1115–1121

    Google Scholar 

  • Lucas JSA, Nieuwenhuizen NJ, Atkinson RG, MacRae EA, Cochrane SA, Warner JO et al (2007) Kiwifruit allergy: actinidin is not a major allergen in the United Kingdom. Clin Exp Allergy 37(9):1340–1348

    Article  CAS  PubMed  Google Scholar 

  • Mace SR, Sussman GL, Liss G, Stark DF, Beezhold D, Thompson R et al (1998) Latex allergy in operating room nurses. Ann Allerg Asthma Im 80(3):252–256

    Article  CAS  Google Scholar 

  • Maddumage R, Nieuwenhuizen NJ, Bulley SM, Cooney JM, Green SA, Atkinson RG (2013) Diversity and relative levels of actinidin, kiwellin, and thaumatin-like allergens in 15 varieties of kiwifruit (Actinidia). J Agric Food Chem 61(3):728–739. doi:10.1021/jf304289f

    Article  CAS  PubMed  Google Scholar 

  • Mattila L, Kilpeláinen M, Terho EO, Koskenvuo M, Helenius H, Kalimo K (2003) Food hypersensitivity among Finnish university students: association with atopic diseases. Clin Exp Allergy 33(5):600–606

    Article  CAS  PubMed  Google Scholar 

  • Migueres M, Dávila I, Frati F, Azpeitia A, Jeanpetit Y, Lhéritier-Barrand M et al (2014) Types of sensitization to aeroallergens: definitions, prevalences and impact on the diagnosis and treatment of allergic respiratory disease. Clin Transl Allergy 4:16. doi:10.1186/2045-7022-4-16

    Article  PubMed  PubMed Central  Google Scholar 

  • Möller M, Paschke A, Vieluf D, Kayma M, Vieths S, Steinhart H (1997) Characterization of allergens in kiwi fruit and detection of cross-reactivities with allergens of birch pollen and related fruit allergens. Food Agric Immunol 9(2):107–121

    Article  Google Scholar 

  • Nieuwenhuizen NJ, Beuning LL, Sutherland PW, Sharma NN, Cooney JM, Bieleski LRF et al (2007) Identification and characterisation of acidic and novel basic forms of actinidin, the highly abundant cysteine protease from kiwifruit. Funct Plant Biol 34(10):946–961

    Article  CAS  Google Scholar 

  • Nieuwenhuizen NJ, Maddumage R, Tsang GK, Fraser LG, Cooney JM, De Silva HN et al (2012) Mapping, complementation, and targets of the cysteine protease actinidin in kiwifruit. Plant Physiol 158(1):376–388

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nishiyama I, Oota T (2002) Varietal difference in actinidin concentration and protease activity in the kiwi fruit juice. J Jpn Soc Food Sci Technol 49(6):401–408

    Article  CAS  Google Scholar 

  • Nishiyama I, Fukuda T, Oota T (2004) Varietal differences in actinidin concentration and protease activity in the fruit juice of Actinidia arguta and Actinidia rufa. J Jpn Soc Hortic Sci 73(2):157–162

    Article  CAS  Google Scholar 

  • Oberhuber C, Bulley S, Bublin M, Ballmer-Weber B, Vieths S, Hoffmann-Sommergruber K (2007) Bet v 1 homologous proteins in kiwi—relevant allergens? Allergy 62:107

    Google Scholar 

  • Oberhuber C, Bulley SM, Ballmer-Weber BK, Bublin M, Gaier S, DeWitt AM et al (2008) Characterization of Bet v 1-related allergens from kiwifruit relevant for patients with combined kiwifruit and birch pollen allergy. Mol Nutr Food Res 52(Suppl 2):S230–S240. doi:10.1002/mnfr.200800146

    PubMed  Google Scholar 

  • Palacin A, Lopez-Torrejon G, Blanco C, Sanchez-Monge R, Varela J, Jiménez M et al (2008a) Act d 1, Act d 2 and Act d 3 are major allergens in patients sensitised to kiwi (Actinidinia deliciosa) with different clinical symptoms. Allergy 63:573

    Google Scholar 

  • Palacin A, Rodriguez J, Blanco C, Lopez-Torrejon G, Sánchez-Monge R, Varela J (2008b) Immunoglobulin E recognition patterns to purified Kiwifruit (Actinidia deliciosa) allergens in patients sensitized to Kiwi with different clinical symptoms. Clin Exp Allergy: J Br Soc Allergy Clin Immunol 38(7):1220–1228. doi:10.1111/j.1365-2222.2007.02927.x

    Article  CAS  Google Scholar 

  • Palacin A, Rodriguez J, Blanco C, Lopez-Torrejon G, Sánchez-Monge R, Varela J et al (2008c) Immunoglobulin E recognition patterns to purified kiwifruit (Actinidinia deliciosa) allergens in patients sensitized to kiwi with different clinical symptoms. Clin Exp Allergy 38(7):1220–1228

    Article  CAS  PubMed  Google Scholar 

  • Palazzo P, Tuppo L, Giangrieco I, Bernardi ML, Rafaiani C, Crescenzo R et al (2013) Prevalence and peculiarities of IgE reactivity to kiwifruit pectin methylesterase and its inhibitor, Act d 7 and Act d 6, in subjects allergic to kiwifruit. Food Res Int 53(1):24–30. doi:10.1016/j.foodres.2013.03.041

    Article  CAS  Google Scholar 

  • Pastorello EA, Pravettoni V, Ispano M, Farioli L, Ansaloni R, Rotondo F et al (1996) Identification of the allergenic components of kiwi fruit and evaluation of their cross-reactivity with timothy and birch pollens. J Allergy Clin Immunol 98(3):601–610

    Article  CAS  PubMed  Google Scholar 

  • Pastorello EA, Conti A, Pravettoni V, Farioli L, Rivolta F, Ansaloni R et al (1998) Identification of actinidin as the major allergen of kiwi fruit. J Allergy Clin Immunol 101(4):531–537

    Article  CAS  PubMed  Google Scholar 

  • Paturi G, Butts CA, Bentley-Hewitt KL, Ansell J (2014) Influence of green and gold kiwifruit on indices of large bowel function in healthy rats. J Food Sci 79(8):H1611–H1620

    Article  CAS  PubMed  Google Scholar 

  • Paul W, Amiss J, Try R, Praekelt U, Scott R, Smith H (1995) Correct processing of the kiwifruit protease actinidin in transgenic tobacco requires the presence of the C-terminal propeptide. Plant Physiol 108(1):261–268

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Popović M, Grozdanović M, Gavrović-Jankulović M (2013) Kiwifruit as a food allergen source. J Serb Chem Soc 78(3):333–352

    Article  Google Scholar 

  • Praekelt UM, McKee RA, Smith H (1988) Molecular analysis of actinidin, the cysteine proteinase of Actinidia chinensis. Plant Mol Biol 10(3):193–202. doi:10.1007/BF00027396

    Article  CAS  PubMed  Google Scholar 

  • Rademaker M (1996) Allergic contact dermatitis from kiwi fruit vine (Actinidia chinensis). Contact Dermatitis 34(3):221–222

    Article  CAS  PubMed  Google Scholar 

  • Ricci G, Righetti F, Menna G, Bellini F, Miniaci A, Masi M (2005) Relationship between Bet v 1 and Bet v 2 specific IgE and food allergy in children with grass pollen respiratory allergy. Mol Immunol 42(10):1251–1257

    Article  CAS  PubMed  Google Scholar 

  • Rudeschko O, Fahlbusch B, Steurich F, Schlenvoigt G, Jäger L (1998) Kiwi allergens and their cross-reactivity with birch, rye, timothy, and mugwort pollen. J Investig Allergol Clin Immunol 8(2):78–84

    CAS  PubMed  Google Scholar 

  • Rutherfurd SM, Montoya CA, Zou ML, Moughan PJ, Drummond LN, Boland MJ (2011) Effect of actinidin from kiwifruit (Actinidia deliciosa cv. Hayward) on the digestion of food proteins determined in the growing rat. Food Chem 129(4):1681–1689

    Article  CAS  Google Scholar 

  • Saha S, Raghava GPS (2006) AlgPred: prediction of allergenic proteins and mapping of IgE epitopes. Nucleic Acids Res 34 (Web Server issue):W202–W209. doi:10.1093/nar/gkl343

    Google Scholar 

  • Sirvent S, Cantó B, Cuesta-Herranz J, Gómez F, Blanca N, Canto G et al (2014a) Act d 12 and Act d 13: Two novel, masked, relevant allergens in kiwifruit seeds. J Allergy Clin Immunol 133(6):1765–1767.e1764

    Google Scholar 

  • Sirvent S, Cantó B, Gómez F, Blanca N, Cuesta-Herranz J, Canto G et al (2014b) Detailed characterization of Act d 12 and Act d 13 from kiwi seeds: implication in IgE cross-reactivity with peanut and tree nuts. Allergy 69(11):1481–1488

    Article  CAS  PubMed  Google Scholar 

  • Taguchi H, Watanabe S, Hirao T, Akiyama H, Sakai S, Watanabe T et al (2007) Specific detection of potentially allergenic kiwifruit in foods using polymerase chain reaction. J Agric Food Chem 55(5):1649–1655

    Article  CAS  PubMed  Google Scholar 

  • Tamburrini M, Cerasuolo I, Carratore V, Stanziola AA, Zofra S, Romano L et al (2005) Kiwellin, a novel protein from kiwi fruit. Purification, biochemical characterization and identification as an allergen. Protein J 24(7–8):423–429

    Article  CAS  PubMed  Google Scholar 

  • Taylor MAJ, Baker KC, Briggs GS, Connerton IF, Cummings NJ, Pratt KA et al (1995) Recombinant pro-regions from papain and papaya proteinase IV are selective high affinity inhibitors of the mature papaya enzymes. Protein Eng 8(1):59–62

    Article  CAS  PubMed  Google Scholar 

  • Tsahouridou PC, Thanassoulopoulos CC (2000) First report of Alternaria alternata as a dieback pathogen of kiwifruit. Plant Dis 84(3):371. doi:10.1094/PDIS.2000.84.3.371C

    Article  Google Scholar 

  • Tuppo L, Giangrieco I, Palazzo P, Bernardi ML, Scala E, Carratore V et al (2008) Kiwellin, a modular protein from green and gold kiwi fruits: Evidence of in vivo and in vitro processing and IgE binding. J Agric Food Chem 56(10):3812–3817

    Article  CAS  PubMed  Google Scholar 

  • Uberti F, Peñas E, Manzoni Y, di Lorenzo C, Ballabio C, Fiocchi A et al (2015) Molecular characterization of allergens in raw and processed kiwifruit. Pediatr Allergy Immunol 26(2):139–144

    Article  PubMed  Google Scholar 

  • Udani JK, Bloom DW (2013) Effects of kivia powder on gut health in patients with occasional constipation: a randomized, double-blind, placebo-controlled study. Nutr J 12:78

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Voitenko V, Poulsen LK, Nielsen L, Norgaard A, Bindslev-Jensen C, Skov PS (1997) Allergenic properties of kiwi-fruit extract: cross-reactivity between kiwi-fruit and birch-pollen allergens. Allergy 52(2):136–143

    Article  CAS  PubMed  Google Scholar 

  • Wagner S, Breiteneder H (2002) The latex-fruit syndrome. Biochem Soc Trans 30:935–940

    Article  CAS  PubMed  Google Scholar 

  • Wan K-S, Lue H-C (2007) Latex allergy in health care workers in Taiwan: prevalence, clinical features. Int Arch Occup Environ Health 80(5):455–457

    Article  PubMed  Google Scholar 

  • Wongrakpanich S, Klaewsongkram J, Chantaphakul H, Ruxrungtham K (2015) Jackfruit anaphylaxis in a latex allergic patient. Asian Pac J Allergy 33(1):65–68

    Google Scholar 

  • Zhen Y, Li Z, Huang H, Wang Y (2004) Molecular Characterization of kiwifruit (Actinidia) cultivars and selections using SSR markers. J Am Soc Hortic Sci 129(3):374–382

    CAS  Google Scholar 

  • Zuidmeer L, Goldhahn K, Rona RJ, Gislason D, Madsen C, Summers C et al (2008) The prevalence of plant food allergies: a systematic review. J Allergy Clin Immunol 121(5):1210–1218. doi:10.1016/j.jaci.2008.02.019

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

The author would like to thank Marcus Davy for his help with plotting Fig. 17.2 as well as a review of the draft manuscript by Dr Ross Atkinson (both employed at The New Zealand Institute of Plant & Food Research Limited).

Author information

Authors and Affiliations

  1. The New Zealand Institute for Plant & Food Research Ltd, 412 no 1 Road, RD 2, 3182, Te Puke, Bay of Plenty, New Zealand

    Sean Michael Bulley

Authors
  1. Sean Michael Bulley
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sean Michael Bulley .

Editor information

Editors and Affiliations

  1. Department of Agriculture, University of Udine, Udine, Italy

    Raffaele Testolin

  2. Chinese Academy of Sciences, South China Botanical Garden, Guangzhou, China

    Hong-Wen Huang

  3. for Plant & Food Research, The New Zealand Institute, Auckland, New Zealand

    Allan Ross Ferguson

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Bulley, S.M. (2016). The Kiwifruit Allergome. In: Testolin, R., Huang, HW., Ferguson, A. (eds) The Kiwifruit Genome. Compendium of Plant Genomes. Springer, Cham. https://doi.org/10.1007/978-3-319-32274-2_17

Download citation

Publish with us

Policies and ethics

Search

Navigation