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Bruton’s Tyrosine Kinase (BTK) Beyond B Lymphocytes: A Protein Kinase with Relevance in Innate Immunity

  • Chapter
Agammaglobulinemia

Part of the book series: Rare Diseases of the Immune System ((RDIS,volume 4))

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Abstract

Bruton’s tyrosine kinase (BTK) is a well-studied molecule that is known to play a critical role in pre-B and B cell receptor signaling. It is crucial for early B cell development in the bone marrow and for B cell activation and differentiation in peripheral lymphoid organs. In addition to its role in B cell development and function, BTK is also expressed in myeloid cell populations. Several groups have investigated the function of BTK in non-B cells of human and murine origin and have identified its role in controlling different aspects of the innate immune response and in diverse pathologies. This chapter summarizes these findings and discusses the possible implications of BTK deficiency in non-B cells involved in the phenotype of human and murine primary immunodeficiencies.

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Acknowledgments

This work was supported by Instituto de Ciencia y Tecnología del Distrito Federal (ICyTDF) (Grant PICSA12-157) and Consejo Nacional de Ciencia y Tecnología (CONACyT) (Grant Salud-202111 and CB-154472).

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Authors and Affiliations

  1. Unidad de Investigación en Inmunodeficiencias, Instituto Nacional de Pediatría-SSa. Cuicuilco, Coyoacán, México City, D.F., México

    G. Lopez-Herrera

  2. Red de Apoyo a la Investigación, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”-Universidad Nacional Autónoma de México, Tlalpan, México City, D.F., México

    J. L. Maravillas-Montero

  3. Departamento de Biomedicina, Instituto de Ciencias de la Salud, Universidad Veracruzana Campus Xalapa, Xalapa, Veracruz, México

    J. C. Rodríguez-Alba

  4. Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados-IPN, Zacatenco, México City, D.F., México

    L. Santos-Argumedo

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  1. G. Lopez-Herrera
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  2. J. L. Maravillas-Montero
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  3. J. C. Rodríguez-Alba
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  4. L. Santos-Argumedo
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Correspondence to L. Santos-Argumedo .

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Editors and Affiliations

  1. Pediatrics Clinic, Department of Clinical and Experimental Sciences, University of Brescia and Spedali Civili of Brescia, Brescia, Italy

    Alessandro Plebani

  2. Pediatrics Clinic, Department of Clinical and Experimental Sciences, University of Brescia and Spedali Civili of Brescia, Brescia, Italy

    Vassilios Lougaris

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Lopez-Herrera, G., Maravillas-Montero, J.L., Rodríguez-Alba, J.C., Santos-Argumedo, L. (2015). Bruton’s Tyrosine Kinase (BTK) Beyond B Lymphocytes: A Protein Kinase with Relevance in Innate Immunity. In: Plebani, A., Lougaris, V. (eds) Agammaglobulinemia. Rare Diseases of the Immune System, vol 4. Springer, Cham. https://doi.org/10.1007/978-3-319-22714-6_7

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  • DOI: https://doi.org/10.1007/978-3-319-22714-6_7

  • Publisher Name: Springer, Cham

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