Abstract
Nanoparticles have many potential applications, especially in biomedical engineering and agriculture, but the toxicity of nanoparticles to plants has received little attention. Previously, we described an increase in the levels of reactive oxygen species (ROS) in rice (Oryza sativa) and Arabidopsis thaliana cells after nanoparticle treatments. We found that ROS resulted in programmed cell death and that the nanoparticles caused a dosage-dependent increase in cell death. Since then, accumulating data have indicated that nanomaterials cause toxicity in diverse organisms. Data from our lab and others indicate that we should critically examine the risks of nanoparticles, so that we can safely take advantage of the tremendous potential benefits of this new technology.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Alimohammadi M, Xu Y, Wang DY, Biris AS, Khodakovskaya MV (2011) Physiological responses induced in tomato plants by a two-component nanostructural system composed of carbon nanotubes conjugated with quantum dots and its in vivo multimodal detection. Nanotechnology 22(29). Artn 295101 doi: 10.1088/0957-4484/22/29/295101
Al-Salim N, Barraclough E, Burgess E, Clothier B, Deurer M, Green S, Malone L, Weir G (2011) Quantum dot transport in soil, plants, and insects. Sci Total Environ 409(17):3237–3248. doi:10.1016/j.scitotenv.2011.05.017
Atha DH, Wang H, Petersen EJ, Cleveland D, Holbrook RD, Jaruga P, Dizdaroglu M, Xing B, Nelson BC (2012) Copper oxide nanoparticle mediated DNA damage in terrestrial plant models. Environ Sci Technol 46(3):1819–1827. doi:10.1021/es202660k
Avanasi R, Jackson WA, Sherwin B, Mudge JF, Anderson TA (2014) C60 fullerene soil sorption, biodegradation, and plant uptake. Environ Sci Technol 48(5):2792–2797. doi:10.1021/es405306w
Asli S, Neumann PM (2009) Colloidal suspensions of clay or titanium dioxide nanoparticles can inhibit leaf growth and transpiration via physical effects on root water transport. Plant, Cell Environ 32(5):577–584. doi:10.1111/j.1365-3040.2009.01952.x
Begum P, Fugetsu B (2012) Phytotoxicity of multi-walled carbon nanotubes on red spinach (Amaranthus tricolor L) and the role of ascorbic acid as an antioxidant. J Hazard Mater 243:212–222. doi:10.1016/j.jhazmat.2012.10.025
Boghossian AA, Ham MH, Choi JH, Strano MS (2011) Biomimetic strategies for solar energy conversion: a technical perspective. Energ Environ Sci 4(10):3834–3843. doi:10.1039/C1ee01363g
Bruchez M Jr, Moronne M, Gin P, Weiss S, Alivisatos AP (1998) Semiconductor nanocrystals as fluorescent biological labels. Science 281(5385):2013–2016. doi:10.1126/science.281.5385.2013
Canas JE, Long M, Nations S, Vadan R, Dai L, Luo M, Ambikapathi R, Lee EH, Olszyk D (2008) Effects of functionalized and nonfunctionalized single-walled carbon nanotubes on root elongation of select crop species. Environ Toxicol Chem SETAC 27(9):1922–1931. doi:10.1897/08-117.1
Carpita N, Sabularse D, Montezinos D, Delmer DP (1979) Determination of the pore size of cell walls of living plant cells. Science 205(4411):1144–1147. doi:10.1126/science.205.4411.1144
Chen R, Ratnikova TA, Stone MB, Lin S, Lard M, Huang G, Hudson JS, Ke PC (2010) Differential uptake of carbon nanoparticles by plant and mammalian cells. Small 6(5):612–617. doi:10.1002/smll.200901911
De La Torre-Roche R, Hawthorne J, Deng Y, Xing B, Cai W, Newman LA, Wang C, Ma X, White JC (2012) Fullerene-enhanced accumulation of p, p’-DDE in agricultural crop species. Environ Sci Technol 46(17):9315–9323. doi:10.1021/es301982w
Dietz KJ, Herth S (2011) Plant nanotoxicology. Trends Plant Sci 16(11):582–589. doi:10.1016/j.tplants.2011.08.003
El-Temsah YS, Joner EJ (2012) Impact of Fe and Ag nanoparticles on seed germination and differences in bioavailability during exposure in aqueous suspension and soil. Environ Toxicol 27(1):42–49. doi:10.1002/tox.20610
Elumalai EK, Vinothkumar P (2013) Role of silver nanoparticle against plant pathogens. Nano Biomed Eng 5(2). doi:10.5101/nbe.v5i2.p90-93
Faisal M, Saquib Q, Alatar AA, Al-Khedhairy AA, Hegazy AK, Musarrat J (2013) Phytotoxic hazards of NiO-nanoparticles in tomato: a study on mechanism of cell death. J Hazard Mater 250:318–332. doi:10.1016/j.jhazmat.2013.01.063
Fan R, Huang YC, Grusak MA, Huang CP, Sherrier DJ (2014) Effects of nano-TiO(2) on the agronomically-relevant Rhizobium-legume symbiosis. Sci Total Environ 466–467:503–512. doi:10.1016/j.scitotenv.2013.07.032
Feng Y, Cui X, He S, Dong G, Chen M, Wang J, Lin X (2013) The role of metal nanoparticles in influencing arbuscular mycorrhizal fungi effects on plant growth. Environ Sci Technol 47(16):9496–9504. doi:10.1021/es402109n
Geisler-Lee J, Wang Q, Yao Y, Zhang W, Geisler M, Li K, Huang Y, Chen Y, Kolmakov A, Ma X (2013) Phytotoxicity, accumulation and transport of silver nanoparticles by Arabidopsis thaliana. Nanotoxicology 7(3):323–337. doi:10.3109/17435390.2012.658094
Giraldo JP, Landry MP, Faltermeier SM, McNicholas TP, Iverson NM, Boghossian AA, Reuel NF, Hilmer AJ, Sen F, Brew JA, Strano MS (2014) Plant nanobionics approach to augment photosynthesis and biochemical sensing. Nat Mater 13(4):400–408. doi:10.1038/nmat3890
Ham MH, Choi JH, Boghossian AA, Jeng ES, Graff RA, Heller DA, Chang AC, Mattis A, Bayburt TH, Grinkova YV, Zeiger AS, Van Vliet KJ, Hobbie EK, Sligar SG, Wraight CA, Strano MS (2010) Photoelectrochemical complexes for solar energy conversion that chemically and autonomously regenerate. Nat Chem 2(11):929–936. doi:10.1038/nchem.822
Hoshino A, Fujioka K, Oku T, Suga M, Sasaki YF, Ohta T, Yasuhara M, Suzuki K, Yamamoto K (2004) Physicochemical properties and cellular toxicity of nanocrystal quantum dots depend on their surface modification. Nano Lett 4(11):2163–2169. doi:10.1021/Nl048715d
Huang P, Ju HW, Min JH, Zhang X, Chung JS, Cheong HS, Kim CS (2012) Molecular and physiological characterization of the Arabidopsis thaliana Oxidation-related Zinc Finger 2, a plasma membrane protein involved in ABA and salt stress response through the ABI2-mediated signaling pathway. Plant Cell Physiol 53(1):193–203. doi:10.1093/pcp/pcr162
Kaveh R, Li YS, Ranjbar S, Tehrani R, Brueck CL, Van Aken B (2013) Changes in Arabidopsis thaliana gene expression in response to silver nanoparticles and silver ions. Environ Sci Technol 47(18):10637–10644. doi:10.1021/es402209w
Khodakovskaya MV, de Silva K, Nedosekin DA, Dervishi E, Biris AS, Shashkov EV, Galanzha EI, Zharov VP (2011) Complex genetic, photothermal, and photoacoustic analysis of nanoparticle-plant interactions. Proc Natl Acad Sci USA 108(3):1028–1033. doi:10.1073/pnas.1008856108
Khodakovskaya MV, de Silva K, Biris AS, Dervishi E, Villagarcia H (2012) Carbon nanotubes induce growth enhancement of tobacco cells. ACS Nano 6(3):2128–2135. doi:10.1021/nn204643g
Klimov VI (2007) Spectral and dynamical properties of multiexcitons in semiconductor nanocrystals. Annu Rev Phys Chem 58:635–673. doi:10.1146/annurev.physchem.58.032806.104537
Koelmel J, Leland T, Wang H, Amarasiriwardena D, Xing B (2013) Investigation of gold nanoparticles uptake and their tissue level distribution in rice plants by laser ablation-inductively coupled-mass spectrometry. Environ Pollut 174:222–228. doi:10.1016/j.envpol.2012.11.026
Kumari M, Mukherjee A, Chandrasekaran N (2009) Genotoxicity of silver nanoparticles in Allium cepa. Sci Total Environ 407(19):5243–5246
Kurepa J, Paunesku T, Vogt S, Arora H, Rabatic BM, Lu J, Wanzer MB, Woloschak GE, Smalle JA (2010) Uptake and distribution of ultrasmall anatase TiO2 Alizarin red S nanoconjugates in Arabidopsis thaliana. Nano Lett 10(7):2296–2302. doi:10.1021/nl903518f
Landa P, Vankova R, Andrlova J, Hodek J, Marsik P, Storchova H, White JC, Vanek T (2012) Nanoparticle-specific changes in Arabidopsis thaliana gene expression after exposure to ZnO, TiO2, and fullerene soot. J Hazard Mater 241–242:55–62. doi:10.1016/j.jhazmat.2012.08.059
Lee WM, An YJ, Yoon H, Kweon HS (2008) Toxicity and bioavailability of copper nanoparticles to the terrestrial plants mung bean (Phaseolus radiatus) and wheat (Triticum aestivum): plant agar test for water-insoluble nanoparticles. Environ Toxicol Chem/SETAC 27(9):1915–1921
Lee CW, Mahendra S, Zodrow K, Li D, Tsai YC, Braam J, Alvarez PJJ (2010) Developmental phytotoxicity of metal oxide nanoparticles to Arabidopsis thaliana. Environ Toxicol Chem 29(3):669–675. doi:10.1002/Etc.58
Lei Z, Mingyu S, Xiao W, Chao L, Chunxiang Q, Liang C, Hao H, Xiaoqing L, Fashui H (2008) Antioxidant stress is promoted by nano-anatase in spinach chloroplasts under UV-B radiation. Biol Trace Elem Res 121(1):69–79. doi:10.1007/s12011-007-8028-0
Lenaghan SC, Li YY, Zhang H, Burris JN, Stewart CN, Parker LE, Zhang MJ (2013) Monitoring the environmental impact of TiO2 nanoparticles using a plant-based sensor network. IEEE Trans Nanotechnol 12(2):182–189. doi:10.1109/Tnano.2013.2242089
Lin C, Fugetsu B, Su Y, Watari F (2009a) Studies on toxicity of multi-walled carbon nanotubes on Arabidopsis T87 suspension cells. J Hazard Mater 170(2–3):578–583
Lin S, Reppert J, Hu Q, Hudson JS, Reid ML, Ratnikova TA, Rao AM, Luo H, Ke PC (2009b) Uptake, translocation, and transmission of carbon nanomaterials in rice plants. Small 5(10):1128–1132. doi:10.1002/smll.200801556
Lin DH, Ji J, Long ZF, Yang K, Wu FC (2012) The influence of dissolved and surface-bound humic acid on the toxicity of TiO2 nanoparticles to Chlorella sp. Water Res 46(14):4477–4487. doi:10.1016/j.watres.2012.05.035
Lin D, Xing B (2007) Phytotoxicity of nanoparticles: inhibition of seed germination and root growth. Environ Pollut 150(2):243–250. doi:10.1016/j.envpol.2007.01.016
Lin D, Xing B (2008) Root uptake and phytotoxicity of ZnO nanoparticles. Environ Sci Technol 42:5580–5585
Liu QL, Chen B, Wang QL, Shi XL, Xiao ZY, Lin JX, Fang XH (2009) Carbon nanotubes as molecular transporters for walled plant cells. Nano Lett 9(3):1007–1010
Liu Q, Zhao Y, Wan Y, Zheng J, Zhang X, Wang C, Fang X, Lin J (2010) Study of the inhibitory effect of water-soluble fullerenes on plant growth at the cellular level. ACS Nano 4(10):5743–5748. doi:10.1021/nn101430g
Lopez-Moreno ML, de la Rosa G, Hernandez-Viezcas JA, Peralta-Videa JR, Gardea-Torresdey JL (2010) X-ray Absorption Spectroscopy (XAS) corroboration of the uptake and storage of CeO2 nanoparticles and assessment of their differential toxicity in four edible plant species. J Agric Food Chem 58(6):3689–3693. doi:10.1021/Jf904472e
Maynard AD, Warheit DB, Philbert MA (2011) The new toxicology of sophisticated materials: nanotoxicology and beyond. Toxicol Sci: Off J Soc Toxicol 120(Suppl 1):S109–S129. doi:10.1093/toxsci/kfq372
Ma C, Chhikara S, Xing B, Musante C, White JC, Dhankher OP (2013) Physiological and molecular response of Arabidopsis thaliana(L.) to nanoparticle cerium and indium oxide exposure. ACS Sustainable Chemistry & Engineering:130610093747005. doi:10.1021/sc400098h
Morales MI, Rico CM, Hernandez-Viezcas JA, Nunez JE, Barrios AC, Tafoya A, Flores-Marges JP, Peralta-Videa JR, Gardea-Torresdey JL (2013) Toxicity assessment of cerium oxide nanoparticles in Cilantro (Coriandrum sativum L.) plants grown in organic soil. J Agric Food Chem 61(26):6224–6230. doi:10.1021/Jf401628v
Musante C, White JC (2012) Toxicity of silver and copper to Cucurbita pepo: differential effects of nano and bulk-size particles. Environ Toxicol 27(9):510–517. doi:10.1002/tox.20667
Nair R, Poulose AC, Nagaoka Y, Yoshida Y, Maekawa T, Kumar DS (2011) Uptake of FITC labeled silica nanoparticles and quantum dots by rice seedlings: effects on seed germination and their potential as biolabels for plants. J Fluoresc 21(6):2057–2068. doi:10.1007/s10895-011-0904-5
Navarro DA, Bisson MA, Aga DS (2012) Investigating uptake of water-dispersible CdSe/ZnS quantum dot nanoparticles by Arabidopsis thaliana plants. J Hazard Mater 211–212:427–435. doi:10.1016/j.jhazmat.2011.12.012
Oberdorster G (2010) Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology. J Intern Med 267(1):89–105. doi:10.1111/j.1365-2796.2009.02187.x
Oberdorster G, Oberdorster E, Oberdorster J (2007) Concepts of nanoparticle dose metric and response metric. Environ Health Perspect 115(6):A290
Oukarroum A, Bras S, Perreault F, Popovic R (2012) Inhibitory effects of silver nanoparticles in two green algae, Chlorella vulgaris and Dunaliella tertiolecta. Ecotoxicol Environ Saf 78:80–85. doi:10.1016/j.ecoenv.2011.11.012
Perreault F, Popovic R, Dewez D (2014) Different toxicity mechanisms between bare and polymer-coated copper oxide nanoparticles in Lemna gibba. Environ Pollut 185:219–227. doi:10.1016/j.envpol.2013.10.027
Poborilova Z, Opatrilova R, Babula P (2013) Toxicity of aluminium oxide nanoparticles demonstrated using a BY-2 plant cell suspension culture model. Environ Exp Bot 91:1–11. doi:10.1016/j.envexpbot.2013.03.002
Pokhrel LR, Dubey B (2013) Evaluation of developmental responses of two crop plants exposed to silver and zinc oxide nanoparticles. Sci Total Environ 452–453:321–332. doi:10.1016/j.scitotenv.2013.02.059
Rico CM, Majumdar S, Duarte-Gardea M, Peralta-Videa JR, Gardea-Torresdey JL (2011) Interaction of nanoparticles with edible plants and their possible implications in the food chain. J Agric Food Chem 59(8):3485–3498. doi:10.1021/jf104517j
Sabo-Attwood T, Unrine JM, Stone JW, Murphy CJ, Ghoshroy S, Blom D, Bertsch PM, Newman LA (2012) Uptake, distribution and toxicity of gold nanoparticles in tobacco (Nicotiana xanthi) seedlings. Nanotoxicology 6(4):353–360. doi:10.3109/17435390.2011.579631
Schwabe F, Schulin R, Limbach LK, Stark W, Burge D, Nowack B (2013) Influence of two types of organic matter on interaction of CeO2 nanoparticles with plants in hydroponic culture. Chemosphere 91(4):512–520. doi:10.1016/j.chemosphere.2012.12.025
Serag MF, Kaji N, Gaillard C, Okamoto Y, Terasaka K, Jabasini M, Tokeshi M, Mizukami H, Bianco A, Baba Y (2011a) Trafficking and subcellular localization of multiwalled carbon nanotubes in plant cells. ACS Nano 5(1):493–499. doi:10.1021/nn102344t
Serag MF, Kaji N, Venturelli E, Okamoto Y, Terasaka K, Tokeshi M, Mizukami H, Braeckmans K, Bianco A, Baba Y (2011b) Functional platform for controlled subcellular distribution of carbon nanotubes. ACS Nano 5(11):9264–9270. doi:10.1021/Nn2035654
Shah V, Belozerova I (2008) Influence of metal nanoparticles on the soil microbial community and germination of lettuce seeds. Water Air Soil Pollut 197(1–4):143–148. doi:10.1007/s11270-008-9797-6
Sharma SS, Dietz KJ (2009) The relationship between metal toxicity and cellular redox imbalance. Trends Plant Sci 14(1):43–50. doi:10.1016/j.tplants.2008.10.007
Shaw AK, Hossain Z (2013) Impact of nano-CuO stress on rice (Oryza sativa L.) seedlings. Chemosphere 93(6):906–915. doi:10.1016/j.chemosphere.2013.05.044
Shen CX, Zhang QF, Li J, Bi FC, Yao N (2010) Induction of programmed cell death in Arabidopsis and rice by single-wall carbon nanotubes. Am J Bot 97(10):1602–1609. doi:10.3732/ajb.1000073
Shi X, von dem Bussche A, Hurt RH, Kane AB, Gao H (2011) Cell entry of one-dimensional nanomaterials occurs by tip recognition and rotation. Nat Nanotechnol 6(11):714–719. doi:10.1038/nnano.2011.151
Shiohara A, Hoshino A, Hanaki K, Suzuki K, Yamamoto K (2004) On the cyto-toxicity caused by quantum dots. Microbiol Immunol 48(9):669–675
Slomberg DL, Schoenfisch MH (2012) Silica nanoparticle phytotoxicity to Arabidopsis thaliana. Environ Sci Technol 46(18):10247–10254. doi:10.1021/es300949f
Stampoulis D, Sinha SK, White JC (2009) Assay-dependent phytotoxicity of nanoparticles to plants. Environ Sci Tech 43(24):9473–9479. doi:10.1021/es901695c
Tan X-m, Lin C, Fugetsu B (2009) Studies on toxicity of multi-walled carbon nanotubes on suspension rice cells. Carbon 47(15):3479–3487. doi:10.1016/j.carbon.2009.08.018
Thwala M, Musee N, Sikhwivhilu L, Wepener V (2013) The oxidative toxicity of Ag and ZnO nanoparticles towards the aquatic plant Spirodela punctuta and the role of testing media parameters. Environ Sci-Process Impacts 15(10):1830–1843. doi:10.1039/C3em00235g
Tripathi S, Sonkar SK, Sarkar S (2011) Growth stimulation of gram (Cicer arietinum) plant by water soluble carbon nanotubes. Nanoscale 3(3):1176–1181. doi:10.1039/c0nr00722f
Valizadeh A, Mikaeili H, Samiei M, Farkhani SM, Zarghami N, Kouhi M, Akbarzadeh A, Davaran S (2012) Quantum dots: synthesis, bioapplications, and toxicity. Nanoscale Res Lett 7(1):480. doi:10.1186/1556-276X-7-480
Wang J, Koo Y, Alexander A, Yang Y, Westerhof S, Zhang QB, Schnoor JL, Colvin VL, Braam J, Alvarez PJJ (2013) Phytostimulation of poplars and Arabidopsis exposed to silver nanoparticles and Ag+ at sublethal concentrations. Environ Sci Technol 47(10):5442–5449. doi:10.1021/Es4004334
Wang S, Kurepa J, Smalle JA (2011) Ultra-small TiO2 nanoparticles disrupt microtubular networks in Arabidopsis thaliana. Plant, Cell Environ 34(5):811–820. doi:10.1111/j.1365-3040.2011.02284.x
Yang F, Liu C, Gao F, Su M, Wu X, Zheng L, Hong F, Yang P (2007) The improvement of spinach growth by nano-anatase TiO2 treatment is related to nitrogen photoreduction. Biol Trace Elem Res 119(1):77–88. doi:10.1007/s12011-007-0046-4
Yang L, Watts DJ (2005) Particle surface characteristics may play an important role in phytotoxicity of alumina nanoparticles. Toxic Lett 158(2):122–132. doi:10.1016/j.toxlet.2005.03.003
Ze Y, Liu C, Wang L, Hong M, Hong F (2011) The regulation of TiO2 nanoparticles on the expression of light-harvesting complex II and photosynthesis of chloroplasts of Arabidopsis thaliana. Biol Trace Elem Res 143(2):1131–1141. doi:10.1007/s12011-010-8901-0
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Li, KE., Chang, ZY., Shen, CX., Yao, N. (2015). Toxicity of Nanomaterials to Plants. In: Siddiqui, M., Al-Whaibi, M., Mohammad, F. (eds) Nanotechnology and Plant Sciences. Springer, Cham. https://doi.org/10.1007/978-3-319-14502-0_6
Download citation
DOI: https://doi.org/10.1007/978-3-319-14502-0_6
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-14501-3
Online ISBN: 978-3-319-14502-0
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)