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Animal Testing

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Metallointercalators

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Abstract

The development of a new anticancer drug is a long, complex and multistep process which is supervised by regulatory authorities from the different countries all around the world [1]. Application of a new drug for admission to the market is supported by preclinical and clinical data, both including the determination of pharmacodynamics, toxicity, antitumour activity, therapeutic index, etc. As preclinical studies are associated with high cost, optimization of animal experiments is crucial for the overall development of a new anticancer agent. Moreover, in vivo efficacy studies remain a determinant panel for advancement of agents to human trials and thus, require cautious design and interpretation from experimental and ethical point of views.

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Authors and Affiliations

  1. Equipe Avenir, INSERM, UMR 866, University of Burgundy, Dijon, France

    Florence Bouyer

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  1. Johnny Moretto
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  2. Bruno Chauffert
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  3. Florence Bouyer
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Correspondence to Florence Bouyer .

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Editors and Affiliations

  1. School of Biomedical & Health Sciences, University of Western Sydney, Penrith South DC, New South Wales, Australia

    Janice Aldrich-Wright

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Moretto, J., Chauffert, B., Bouyer, F. (2011). Animal Testing. In: Aldrich-Wright, J. (eds) Metallointercalators. Springer, Vienna. https://doi.org/10.1007/978-3-211-99079-7_16

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