Abstract
It is well documented that stimulation of central serotonergic receptors causes thermoregulatory changes in a variety of species, and the 5-hydroxytryptamine (5-HT) activity within the preoptic anterior hypothalamus (POAH) plays an important role in body temperature (Tb) regulation (for review see 1,2). As compared with other monoamines, few studies have been carried out to examine the local sensitivity to 5-HT in sites other than the hypothalamus. Recently, we have shown that injection of 5-HT into the lateral septum causes a dose-related fall in Tb in rats kept at 20°C (3). This thermoregulatory change appears to be site-specific, since injection of the same doses of 5-HT into the hippocampal area fails to elicit any significant changes in Tb.
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© 1994 Birkhäuser Verlag Basel
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Wang, L.C.H., Cui, Y., Lee, T.F. (1994). Is the Hypothalamic Serotonergic System Involved in Septal 5-HT-Induced Hypothermia in Rats?. In: Zeisberger, E., Schönbaum, E., Lomax, P. (eds) Thermal Balance in Health and Disease. APS Advances in Pharmacological Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7429-8_66
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DOI: https://doi.org/10.1007/978-3-0348-7429-8_66
Publisher Name: Birkhäuser Basel
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