Abstract
ONO-3144 (2-aminomethyl-4-tert-butyl-6-propionylphenol hydrochloride) is a nonsteroidal antiinflammatory agent, which does not inhibit cyclo-oxygenase activity (1). The antiinflammatory action of this compound is thought to be due to its ability to scavenge proinflammatory free radicals (1–3). Prostaglandin (PG) biosynthesis is affected, however, by ONO-3144 stimulating PG hydroperoxidase activity converting PGG2 to PGH2, and inhibiting thromboxane synthetase. Despite the facilitated formation of PGH2 and consequently of PGE2, an important mediator of fever (4), ONO-3144 has been reported to produce antipyresis in febrile rats (5). In view of these apparently paradoxical effects by ONO-3144 on PGE2 production and fever in the rat, and because antipyretic drugs can have different effects in models of fever in rats and rabbits (6), the potential antipyretic activity of ONO-3144 in rabbits has been investigated in this study.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Aishita, H, Morimura, T, Obata, T, Miura, Y, Miyamoto, T, Tsuboshima, M, Mizushima, Y (1983): ONO-3144, a new anti-inflammatory drug and its possible mechanism of action. Arch Int Pharmacodyn Ther 261, 316–327.
Crowshaw, K (1984): Role of inhibition of prostaglandin biosynthesis by antiinflammatory drugs in the pathogenesis of renal damage. Adv Inflammation Res 6, 149–158.
Cheeseman, KH, Forni, LG (1988): An investigation of the novel anti-inflammatory agents ONO-3144 and MK-447: studies on their potential antioxidant activity. Biochem Pharmacol 37, 4225–4233.
Milton, AS (1982): Prostaglandins in fever and the mode of action of antipyretic drugs. Handbk Exp Pharmacol 60, 257–303.
Aishita, H, Morimura, T, Sakai, Y, Sakaguchi H, Tsuboshima, M (1982): Biochemical and pharmacological activities of 2-aminomethyl-4-tert-butyl-6-propionylphenol. Ensho 2, 465–466.
Dascombe, MJ (1984): Effects of diflunisal on fever in the rabbit and the rat. J Pharm Pharmacol 36, 437–440.
Dascombe, MJ, Milton, AS (1975): The effects of cyclic adenosine 3′,5′-monophosphate and other adenine nucleotides on body temperature. J Physiol (Lond) 250, 143–160.
Gunn, JA (1913): An apparatus for perfusing the mammalian heart. J Physiol (Lond) 46, 506–508.
Furchgott, RF, Bhadrakom, S (1953): Reactions of strips of rabbit aorta to epinephrine, isopropylarterenol, sodium nitrite and other drugs. J Pharmacol Exp Ther 108, 129–143.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Birkhäuser Verlag Basel
About this chapter
Cite this chapter
Dascombe, M.J. (1994). Thermoregulatory and Cardiovascular Effects of ONO-3144 in the Rabbit. In: Zeisberger, E., Schönbaum, E., Lomax, P. (eds) Thermal Balance in Health and Disease. APS Advances in Pharmacological Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7429-8_63
Download citation
DOI: https://doi.org/10.1007/978-3-0348-7429-8_63
Publisher Name: Birkhäuser Basel
Print ISBN: 978-3-0348-7431-1
Online ISBN: 978-3-0348-7429-8
eBook Packages: Springer Book Archive