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Aspects of Potassium Channel Modulation

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Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s

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Abstract

Advances in molecular biology are giving unprecedented insights into potassium (K)-channel structure and function. In parallel, the development of channel modulators and their investigation using electrophysiological techniques has revealed much, but posed many questions. What is the importance of the recently-discovered channel β-subunits? What is the nature of the so-called ATP-sensitive K-channel and how do K-channel openers exert tissue-protective actions? Can the K-channels in lymphocytes be exploited therapeutically? The purpose of this chapter is to give the reader an insight into this dynamic pharmacological field and to provide a stimulus for further discussion and experimentation. Correspondence to: Gillian Edwards, address as above.

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Author information

Authors and Affiliations

  1. School of Biological Sciences, University of Manchester, G.38 Stopford Building, Oxford Road, Manchester, M13 9PT, UK

    Gillian Edwards & Arthur H. Weston

  2. Rhône-Poulenc Rorer, Centre de Recherche de Vitry-Alfortville, 13, Quai Jules Guesde, 94400, Vitry Sur Seine, France

    Icilio Cavero

  3. Merck Sharp & Dohme Research Laboratories, P.O. Box 2000, Rahway, New Jersey, 07065-0900, USA

    Gregory J. Kaczorowski

  4. Zentrum für Molekuläre Neurobiologie, Institut für Neurale Signalverarbeitung, Martinistraße 52–Haus 42, D-20246, Hamburg, Germany

    Olaf Pongs

  5. Pharmakologisches Institut, Eberhard-Karls-Universität, Wilhelmstraße 56, D-7400, Tübingen 1, Germany

    Uli Quast

  6. Tohoku University School of Medicine, Aoba-ku 980, Sendai, Japan

    Norio Taira

Authors
  1. Gillian Edwards
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  2. Icilio Cavero
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  3. Gregory J. Kaczorowski
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  4. Olaf Pongs
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  5. Uli Quast
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  6. Norio Taira
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  7. Arthur H. Weston
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Editor information

Editors and Affiliations

  1. Department of Pharmacology and Therapeutics Mclntyre Medical Sciences Building, McGill University, 3655 Drummond Street, Montreal, Quebec, Canada, H3G 1Y6

    A. Claudio Cuello  & Brian Collier  & 

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© 1995 Birkhäuser Verlag Basel/Switzerland

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Edwards, G. et al. (1995). Aspects of Potassium Channel Modulation. In: Cuello, A.C., Collier, B. (eds) Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7218-8_13

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  • DOI: https://doi.org/10.1007/978-3-0348-7218-8_13

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7220-1

  • Online ISBN: 978-3-0348-7218-8

  • eBook Packages: Springer Book Archive

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