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Mechanisms and Significance of Bacterial Resistance to Human Cationic Antimicrobial Peptides

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Antimicrobial Peptides and Innate Immunity

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Cationic antimicrobial peptides (CAMPs) are essential compounds of the innate immunity system possessed by humans. CAMPs protect the host by exerting bactericidal activity, molecular signaling, modulating the immune response, and facilitating the communication between innate and acquired immunity. Over the millennia, bacteria have developed mechanisms to circumvent the antimicrobial activity of CAMPs, thereby promoting their survival during infection. In this chapter, we focus on the mechanisms used by various bacterial pathogens to resist the antibiotic-like action of CAMPs and the consequences of such resistance.

Maira Goytia and Justin L. Kandler contributed equally.

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Acknowledgments

We wish to thank Lane Pucko for help in manuscript preparation and P. Rather for critical review. The senior author (W. M. S.) is indebted to J.K. Spitznagel, M.D., for his mentorship and introducing him to CAMP research 30 years ago. This work was supported by the NIH grants R37 AI021150 and U19 AI031496 and a VA Merit Award from the Department of Veterans Affairs. W. M. S. was supported in part by a Senior Research Career Scientist Award from the Department of Veterans Affairs.

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  1. Department of Microbiology and Immunology, School of Medicine, Emory University, Rollins Research Center, Suite 3001, 1510 Clifton Road, Atlanta, GA, 30322, USA

    Maira Goytia, Justin L. Kandler & William M. Shafer

  2. Veterans Affairs Medical Research, Veterans Affairs Medical Center, 1670 Clairmont Road, Room 5A181, Decatur, GA, 30033, USA

    William M. Shafer

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  1. Maira Goytia
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  2. Justin L. Kandler
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  3. William M. Shafer
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Correspondence to William M. Shafer .

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  1. , Department of Pulmonology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2300 RC, Netherlands

    Pieter S. Hiemstra

  2. Ctr for Infection & Immun. Amsterdam, Dept. Medical Microbiology, University of Amsterdam, Meibergdreef 15, Amsterdam, 1105 AZ, Netherlands

    Sebastian A. J. Zaat

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Goytia, M., Kandler, J.L., Shafer, W.M. (2013). Mechanisms and Significance of Bacterial Resistance to Human Cationic Antimicrobial Peptides. In: Hiemstra, P., Zaat, S. (eds) Antimicrobial Peptides and Innate Immunity. Progress in Inflammation Research. Springer, Basel. https://doi.org/10.1007/978-3-0348-0541-4_9

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