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Phagosome Maturation: A Few Bugs in the System

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Abstract

Cells of the innate immune system ingest and destroy invading microorganisms by initially engulfing them into a specialized vacuole, known as the phagosome. The membrane of the forming phagosome is similar to the plasmalemma and its contents resemble the extracellular milieu. As such, the nascent phagosome is not competent to kill and eliminate the ingested microorganisms. However, shortly after sealing, the phagosome undergoes a series of rapid and extensive changes in its composition, the result of a sophisticated sequence of membrane fusion and fission reactions. Understanding the molecular basis of these events is of particular importance, since they are often the target of disruption by intracellular parasites such as Mycobacterium, Salmonella and Legionella. The objective of this review is to summarize the current knowledge of the molecular mechanisms underlying phagosomal maturation and its subversion by parasitic microorganisms.

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Acknowledgements

We thank Dr. John Brumell for his helpful comments on this manuscript, Dr. Rene Harrison for providing the Rab7-GFP and RILP-GFP images (Figs. 3, 4), and Richard Collins for providing the Syntaxin-GFP images (Figs. 2, 3). Research in the author’s laboratory is supported by the Canadian Institutes of Health Research (CIHR), the Canadian Arthritis Society and the National Sanatorium Association. C.C.S. and RJ.B. are supported by CIHR Graduate Studentships. S.G. is a CIHR Distinguished Scientist.

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  1. Programme in Cell Biology, The Hospital for Sick Children and Department of Biochemistry, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada

    C. C. Scott, R. J. Botelho & S. Grinstein

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Scott, C., Botelho, R. & Grinstein, S. Phagosome Maturation: A Few Bugs in the System . J. Membrane Biol. 193, 137–152 (2003). https://doi.org/10.1007/s00232-002-2008-2

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