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Extracellular Vesicle Mediated Vascular Pathology in Glioblastoma

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New Frontiers: Extracellular Vesicles

Part of the book series: Subcellular Biochemistry ((SCBI,volume 97))

Abstract

Glioblastoma (GBM) is an incurable, infiltrative high-grade brain tumour associated with dramatic vascular responses observed both locally (angiogenesis, vascular cooption, angiocrine effects, microthrombosis) and systemically (venous thromboembolism). GBM-associated vascular pathology is diagnostically relevant and constitutes a source of morbidity, mortality and progressive changes in tumour biology. Extracellular vesicles (EVs) have emerged as unique mediators of vascular effects in brain tumours acting as vehicles for intercellular transfer of oncoproteins (e.g. EGFRvIII), RNA, DNA and molecular effectors of angiogenesis and thrombosis. Vascular effects of GBM EVs are regulated by cancer cell genome, epigenome and microenvironment and differ between subtypes of cancer cells and stem cells. Understanding and targeting EV-driven vascular processes in GBM may offer new approaches to diagnose and treat these intractable tumours.

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Acknowledgements

This work was supported by the operating grants from Canadian Institutes for Health Research (CIHR Foundation grant FDN143322) and Cancer Research Society (CRS) to J.R. J. R, who is also a recipient of the Jack Cole Chair in Pediatric Hematology/Oncology. Infrastructure funds were provided by the Fonds de Recherche en Santé du Quebec (FRSQ) which also provided support for C.S., N.T. and L. A. who was also a recipient of a bursary from McGill Faculty of Medicine and The Michael Whitehead and Louise Penny Endowment Fund to Montreal Children’s Hospital Foundation. We are grateful to our families for their support.

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  1. McGill University and the Research Institute of the McGill University Health Centre, QC, Canada

    Cristiana Spinelli, Nadim Tawil, Lata Adnani, Janusz Rak & Dongsic Choi

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  1. Cristiana Spinelli
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  2. Nadim Tawil
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  3. Lata Adnani
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  4. Janusz Rak
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  5. Dongsic Choi
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Correspondence to Janusz Rak or Dongsic Choi .

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  1. Department of Biochemistry and Genetics La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia

    Suresh Mathivanan

  2. Department of Biochemistry and Genetics La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia

    Pamali Fonseka

  3. Department of Biochemistry and Genetics La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia

    Christina Nedeva

  4. Department of Biochemistry and Genetics La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia

    Ishara Atukorala

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Spinelli, C., Tawil, N., Adnani, L., Rak, J., Choi, D. (2021). Extracellular Vesicle Mediated Vascular Pathology in Glioblastoma. In: Mathivanan, S., Fonseka, P., Nedeva, C., Atukorala, I. (eds) New Frontiers: Extracellular Vesicles. Subcellular Biochemistry, vol 97. Springer, Cham. https://doi.org/10.1007/978-3-030-67171-6_10

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