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Biosensors Utilizing Consecutive and Parallel Substrates Conversion

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Mathematical Modeling of Biosensors

Part of the book series: Springer Series on Chemical Sensors and Biosensors ((SSSENSORS,volume 9))

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Abstract

Coupling different enzymes either in sequence or in competition pathway is a way to enhance the range of analyte species accessible to measurement, the selectivity and the sensitivity of biosensors. In this chapter, mathematical models of several types of amperometric multi-enzyme biosensors utilizing consecutive or parallel substrates conversion are modeled and analysed at stationary and transient conditions. A biosensor based on bienzyme electrode with co-immobilized D-glucose oxidase and peroxidase is considered under stationary conditions at excess concentrations of oxygen and ferrocyanide. A trienzyme biosensor utilizing consecutive substrates conversion with three enzymes is modeled at internal diffusion limitation. A biosensor with dual catalase-peroxidase bioelectrode is mathematically modeled by nonlinear reaction–diffusion equations. Finally, multi-enzyme biosensors utilizing parallel and competitive multi-substrate conversion are analysed.

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Authors and Affiliations

  1. Faculty of Mathematics & Informatics, Institute of Computer Science, Vilnius University, Vilnius, Lithuania

    Romas Baronas & Feliksas Ivanauskas

  2. Life Sciences Center, Vilnius University, Vilnius, Lithuania

    Juozas Kulys

Authors
  1. Romas Baronas
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  2. Feliksas Ivanauskas
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  3. Juozas Kulys
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Baronas, R., Ivanauskas, F., Kulys, J. (2021). Biosensors Utilizing Consecutive and Parallel Substrates Conversion. In: Mathematical Modeling of Biosensors. Springer Series on Chemical Sensors and Biosensors, vol 9. Springer, Cham. https://doi.org/10.1007/978-3-030-65505-1_3

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