Abstract
Dermatophytes are a group of fungal agents that can invade humans’ keratinized tissues such as skin, nail, and hair, thereby causing dermatophyte infection (dermatophytosis) or ringworm. Some natural products have been reported to possess fungicidal effects. Hence, the present study investigated the effect of curcuminoids (CUR) and difluorinated curcumin (CDF) against clinical isolates of dermatophytes. CUR and CDF powders were evaluated against dermatophyte species including Trichophyton tonsurans (n = 21), T. mentagrophytes (n = 19), T. interdigitale (n = 18), Microsporum canis (n = 4), T. benhamiae (n = 1), and T. verrucosum (n = 1), based on the CLSI M38-A2 guideline. The minimum inhibitory concentration (MIC) ranges of CUR were 4–16, 8–16, 4–16, 8, 8, and 16 μg/ml for T. tonsurans, T. mentagrophytes, T. interdigitale, M. canis, T. benhamiae, and T. verrucosum, respectively. In addition, MIC ranges of CDF were obtained as 2–32, 4–16, 0.125–16, 8–16, 8, and 16 μg/ml, for T. tonsurans, T. mentagrophytes, T. interdigitale, M. canis, T. benhamiae, and T. verrucosum, respectively. CUR and CDF showed an inhibitory effect against dermatophyte isolates. CDF showed a stronger effect than CUR, especially against T. interdigitale. CUR and CDF have the capacity to be developed for use in dermatophytosis to augment existing preventative/therapeutic strategies.
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Acknowledgments
We appreciate the staff of Medical Mycology and Parasitology Laboratory in Ghaem Teaching hospitals affiliated to Mashhad University of Medical Sciences. This work was financially supported by the Deputy of Research of Mashhad University of Medical Sciences (grant No. 951808).
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The authors declare that they have no conflicts of interest.
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Zarrinfar, H., Behnam, M., Hatamipour, M., Sahebkar, A. (2021). Antifungal Activities of Curcuminoids and Difluorinated Curcumin Against Clinical Dermatophyte Isolates. In: Barreto, G.E., Sahebkar, A. (eds) Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health. Advances in Experimental Medicine and Biology, vol 1308. Springer, Cham. https://doi.org/10.1007/978-3-030-64872-5_8
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