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Advanced Three-Dimensional Optical Mapping

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Cardiac Bioelectric Therapy

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Abstract

Optical imaging using voltage-sensitive dyes is a widely used technique in cardiac electrophysiology, which has been extensively applied to the study of arrhythmias. It allows for high spatial and temporal resolution acquisitions of propagating action potentials in cardiac tissues. However, cardiac arrhythmias, and especially ventricular arrhythmias in the larger mammalian species, are complex three-dimensional phenomena that ideally require three-dimensional depth-resolved mapping through the myocardial wall thickness to be fully understood. In its most basic application, i.e., epi-fluorescence, cardiac optical imaging provides only limited information about intramural activity. Nonetheless, the recent development of near-infrared voltage-sensitive dyes and imaging modalities, such as transillumination, have paved the way for novel three-dimensional optical imaging techniques aiming at depth-resolved reconstruction of cardiac electrical activity.

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Authors and Affiliations

  1. Université de Bordeaux, Electrophysiology and Heart Modeling Institute Liryc, CRCTB U1045, Avenue du Haut-Lévèque – Xavier Arnozan, Pessac, France

    Olivier Bernus & Richard D. Walton

Authors
  1. Olivier Bernus
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  2. Richard D. Walton
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Correspondence to Olivier Bernus .

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Editors and Affiliations

  1. Department of Biomedical Engineering, The George Washington University, Washington, DC, USA

    Igor R. Efimov

  2. National Heart & Lung Institute, Imperial College London, London, UK

    Fu Siong Ng

  3. Philips EPD Solutions, Cambridge, MA, USA

    Jacob I. Laughner

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Bernus, O., Walton, R.D. (2021). Advanced Three-Dimensional Optical Mapping. In: Efimov, I.R., Ng, F.S., Laughner, J.I. (eds) Cardiac Bioelectric Therapy. Springer, Cham. https://doi.org/10.1007/978-3-030-63355-4_14

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  • DOI: https://doi.org/10.1007/978-3-030-63355-4_14

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